Recent developments in brain tumor predisposing syndromes.
Umeå, Sweden. In Acta Oncol, Jan 2016
In this review we are discussing some of the most common predisposition disorders, namely: neurofibromatosis type 1 and 2, schwannomatosis, rhabdoid tumor predisposition disorder, nevoid basal cell carcinoma syndrome (Gorlin), tuberous sclerosis complex, von Hippel-Lindau, Li-Fraumeni and Turcot syndromes.
A lactate-induced response to hypoxia.
Taejŏn, South Korea. In Cell, May 2015
We find that the NDRG3 protein is degraded in a PHD2/VHL-dependent manner in normoxia but is protected from destruction by binding to lactate that accumulates under hypoxia.
VHL, the story of a tumour suppressor gene.
Cambridge, United Kingdom. In Nat Rev Cancer, 2015
Since the Von Hippel-Lindau (VHL) disease tumour suppressor gene VHL was identified in 1993 as the genetic basis for a rare disorder, it has proved to be of wide medical and scientific interest.
Von Hippel-Lindau disease.
More papers using
Bethesda, United States. In Handb Clin Neurol, 2014
von Hippel-Lindau (VHL) disease is an inheritable condition with an incidence of 1 in 36000 live births.