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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Von Hippel-Lindau

von Hippel-Lindau, VHL, dVHL
Top mentioned proteins: VHL, CAN, HAD, XRCC1, vascular endothelial growth factor
Papers using von Hippel-Lindau antibodies
TS-1 enhances the effect of radiotherapy by suppressing radiation-induced hypoxia-inducible factor-1 activation and inducing endothelial cell apoptosis
Hiraoka M et al., In British Journal of Cancer, 2007
... cell carcinoma cell lines (RCC4) stably transfected with pcDNA3 (an empty vector) and pcDNA3-VHL (a VHL-expressing vector), respectively, were purchased from DS Pharma Biomedical (Osaka, Japan) ...
VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400
Gnarra James R. et al., In Oncogene, 2007
... Anti-VHL (Ig32) was purchased from BD Pharmingen, anti-HA (Y-11), anti-cyclin B1, anti-cdc27 and anti-VHL (FL-181) antibodies were purchased from Santa Cruz Biotechnology, and anti-myc (9E10) antibody ...
The expression of the von Hippel-Lindau gene product and its impact on invasiveness of human breast cancer cells
Rozakis-Adcock M et al., In Oncogene, 2006
... (Santa Cruz, CA, USA); Phospho-Erk1/2 and Erk1/2 antibodies from Zymed Laboratories (San Francisco, CA, USA); VHL antibodies from BD Biosciences (San Jose, CA, USA) ...
C-terminal modifications regulate MDM2 dissociation and nuclear export of p53.
Jin Dong-Yan, In PLoS ONE, 2006
... The VHL antibodies were from Cell signaling technology Inc ...
TRAF6-mediated ubiquitination regulates nuclear translocation of NRIF, the p75 receptor interactor.
Koritzinsky Marianne, In PLoS ONE, 2004
... pVHL antibody was from BD Biosciences (Bedford, MA) ...
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Papers on von Hippel-Lindau
Axitinib for the treatment of metastatic renal cell carcinoma.
Rini et al., Cleveland, United States. In Future Oncol, Feb 2016
UNASSIGNED: Renal cell carcinoma is a cancer that results from a genetic inactivation of the VHL tumor suppressor gene leading to an upregulation of VEGF.
An ID2-dependent mechanism for VHL inactivation in cancer.
Lasorella et al., New York City, United States. In Nature, Feb 2016
ID2 binds to the VHL ubiquitin ligase complex, displaces VHL-associated Cullin 2, and impairs HIF2α ubiquitylation and degradation.
Hypoxia Promotes Cancer Stem Cells via ID2-Dependent VHL Inactivation.
In Cancer Discov, Feb 2016
UNASSIGNED: Hypoxia inactivates DYRK1, preventing ID2 phosphorylation and promoting CSCs and HIF2α stabilization.
Formation of renal cysts and tumors in Vhl/Trp53-deficient mice requires HIF-1α and HIF-2α.
Frew et al., Zürich, Switzerland. In Cancer Res, Feb 2016
UNASSIGNED: The von Hippel-Lindau (VHL) tumor suppressor gene is inactivated in the majority of clear cell renal cell carcinomas (ccRCC), but genetic ablation of Vhl alone in mouse models is insufficient to recapitulate human tumorigenesis.
Von Hippel-Lindau disease: an evaluation of natural history and functional disability.
Opocher et al., Modena, Italy. In Neuro Oncol, Feb 2016
BACKGROUND: Although many studies have been published about specific lesions characterizing von Hippel-Lindau(VHL) disease, none have dealt with the natural history of the whole disease and the consequent disabilities.
Identification of DNA methylation-independent epigenetic events underlying clear cell renal cell carcinoma.
Liang et al., United States. In Cancer Res, Feb 2016
Compared to commonly mutated genes in ccRCC, such as the von Hippel-Lindau (VHL) tumor suppressor, the genes identified by AcceSssIble comprised distinct pathways and more frequently underwent epigenetic changes, suggesting that genetic and epigenetic alterations could be independent events in ccRCC.
Down-regulation of C12orf59 is associated with a poor prognosis and VHL mutations in renal cell carcinoma.
Li et al., Shenzhen, China. In Oncotarget, Feb 2016
VHL non-sense mutations or frame-shift mutations (P < 0.01), and UMPP gene non-sense mutations or frame-shift mutations (P = 0.01).
Recent developments in brain tumor predisposing syndromes.
Melin et al., Umeå, Sweden. In Acta Oncol, Jan 2016
In this review we are discussing some of the most common predisposition disorders, namely: neurofibromatosis type 1 and 2, schwannomatosis, rhabdoid tumor predisposition disorder, nevoid basal cell carcinoma syndrome (Gorlin), tuberous sclerosis complex, von Hippel-Lindau, Li-Fraumeni and Turcot syndromes.
Jade-1: its structure, regulation and functions in the renal cancer.
Pei et al., Xuzhou, China. In Curr Mol Med, Dec 2015
Jade-1 is originally identified by the yeast two-hybrid system as a protein partner of von Hippel-Lindau (pVHL) tumor suppressor, a well-known renal tumor suppressor.
E3 Ubiquitin Ligase VHL Regulates Hypoxia-Inducible Factor-1α to Maintain Regulatory T Cell Stability and Suppressive Capacity.
Liu et al., Los Angeles, United States. In Immunity, Jul 2015
Here, we report that the E3 ubiquitin ligase VHL is essential for Treg cell function.
A lactate-induced response to hypoxia.
Yeom et al., Taejŏn, South Korea. In Cell, May 2015
We find that the NDRG3 protein is degraded in a PHD2/VHL-dependent manner in normoxia but is protected from destruction by binding to lactate that accumulates under hypoxia.
VHL, the story of a tumour suppressor gene.
Maher et al., Cambridge, United Kingdom. In Nat Rev Cancer, 2015
Since the Von Hippel-Lindau (VHL) disease tumour suppressor gene VHL was identified in 1993 as the genetic basis for a rare disorder, it has proved to be of wide medical and scientific interest.
[Hereditary pheochromocytoma-associated syndromes. Part 1].
Beltsevich et al., In Ter Arkh, 2014
There have been the most investigated NF, RET, VHL, SDHD, SDHC, and SDHB gene mutations.
Von Hippel-Lindau disease.
Lonser et al., Bethesda, United States. In Handb Clin Neurol, 2014
von Hippel-Lindau (VHL) disease is an inheritable condition with an incidence of 1 in 36000 live births.
TRPM3 and miR-204 establish a regulatory circuit that controls oncogenic autophagy in clear cell renal cell carcinoma.
Czyzyk-Krzeska et al., Cincinnati, United States. In Cancer Cell, 2014
The von Hippel-Lindau tumor suppressor (VHL) represses TRPM3 directly through miR-204 and indirectly through another miR-204 target, Caveolin 1 (CAV1).
Drosophila Mgr, a Prefoldin subunit cooperating with von Hippel Lindau to regulate tubulin stability.
Glover et al., Cambridge, United Kingdom. In Proc Natl Acad Sci U S A, 2012
Codepletion of Vhl with Mgr gives partial rescue of tubulin instability, monopolar spindle formation, and loss of centrosomes.
Drosophila VHL tumor-suppressor gene regulates epithelial morphogenesis by promoting microtubule and aPKC stability.
Hsu et al., Bologna, Italy. In Development, 2010
The results establish a developmental function of the VHL gene that is relevant to its tumor-suppressor activity.
Regulation of Drosophila embryonic tracheogenesis by dVHL and hypoxia.
Moberg et al., Atlanta, United States. In Dev Biol, 2009
findings reveal a second type of tracheal hypoxic response in which Sima activation conflicts with developmental tracheogenesis, and identify the dVHL and ago ubiquitin ligases as key determinants of hypoxia sensitivity in tracheal cells
More papers using von Hippel-Lindau antibodies
Activation of the hypoxia-inducible factor-pathway and stimulation of angiogenesis by application of prolyl hydroxylase inhibitors.
Kalinichenko Vladimir V., In PLoS ONE, 2002
... Conditional VHL knockout mice were generated by crossbreeding three different transgenic mouse lines: a) floxed ...
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