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VMA7 Vma7p

Vma7p, vma7, ATP6V1F, vacuolar ATP synthase subunit F, VATF
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is the V1 domain F subunit protein. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ATPase, V-ATPase, 14-kDa, ACID, fibrillin-1
Papers on Vma7p
Polygenic analysis and targeted improvement of the complex trait of high acetic acid tolerance in the yeast Saccharomyces cerevisiae.
Thevelein et al., Leuven, Belgium. In Biotechnol Biofuels, Dec 2015
Novel genes determining high acetic acid tolerance, GLO1, DOT5, CUP2, and a previously identified component, VMA7, were identified as causative alleles in the second major F1 QTL and in three newly appearing F7 QTLs, respectively.
Crystallization and preliminary X-ray crystallographic analysis of subunit F (F(1-94)), an essential coupling subunit of the eukaryotic V(1)V(O)-ATPase from Saccharomyces cerevisiae.
Grüber et al., Singapore, Singapore. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2012
native crystals of VMA7 diffracted to a resolution of 2.64 A and belonged to space group C222(1), with unit-cell parameters a = 47.21, b = 160.26, c = 102.49 A
Cloning and overexpression of an important functional gene ATP6V1F encoding a component of vacuolar ATPase from the Giant Panda (Ailuropoda melanoleuca).
Hou et al., Zhanjiang, China. In Mol Biol Rep, 2012
ATP6V1F encodes a component of vacuolar ATPase mediating acidification.
Solution structure of subunit F (Vma7p) of the eukaryotic V(1)V(O) ATPase from Saccharomyces cerevisiae derived from SAXS and NMR spectroscopy.
Grüber et al., Singapore, Singapore. In Biochim Biophys Acta, 2011
Here we present the first low resolution structure of recombinant subunit F (Vma7p) of a eukaryotic V-ATPase from Saccharomyces cerevisiae, analyzed by small angle X-ray scattering (SAXS).
Biological effects of a new vacuolar-H,-ATPase inhibitor in colon carcinoma cell lines.
Zunino et al., Milano, Italy. In Ann N Y Acad Sci, 2009
Results show that NiK-12192, by affecting vacuolar- H(+)-ATPase activity (and intracellular pH), causes a modification of structures crucial for cell adhesion and induces cell death, likely by a modality involving an anoikis-mediated apoptosis.
Analysis of whole genomic expression profiles of Helicobacter pylori related chronic atrophic gastritis with IL-1B-31CC/-511TT genotypes.
Gao et al., Shanghai, China. In J Dig Dis, 2009
Five overlapping genes were contained in identified GO terms and pathways: ATP6V0B, NDUFS5, NDUFV2, ATP6V1F and ATP6V1G1.
The vacuolar-ATPase complex regulates retinoblast proliferation and survival, photoreceptor morphogenesis, and pigmentation in the zebrafish eye.
Gross et al., Austin, United States. In Invest Ophthalmol Vis Sci, 2009
This study was conducted to characterize ocular defects in five zebrafish mutants in which core components of the v-ATPase complex were affected (atp6v1h, atp6v1f, atp6v1e1, atp6v0c, and atp6v0d1), as well as a sixth mutant in which a v-ATPase associated protein (atp6ap1) was affected.
The putative vacuolar ATPase subunit Vma7p of Candida albicans is involved in vacuole acidification, hyphal development and virulence.
Eck et al., Jena, Germany. In Microbiology, 2005
In addition, C. albicans vma7 null mutants and the null mutant strain of the Vma7p-interacting phosphatidylinositol 3-kinase Vps34p showed similar phenotypes.
The phosphatidylinositol 3-kinase Vps34p of the human pathogenic yeast Candida albicans is a multifunctional protein that interacts with the putative vacuolar H+ -ATPase subunit Vma7p.
Zipfel et al., Jena, Germany. In Int J Med Microbiol, 2005
In order to characterize the functional link between these two activities we searched for proteins interacting with C. albicans Vps34p and demonstrate physical interaction of Vps34p with the subunit of the vacuolar H+ -ATPase Vma7p.
Up-regulated expression of the MAT-8 gene in prostate cancer and its siRNA-mediated inhibition of expression induces a decrease in proliferation of human prostate carcinoma cells.
Burfeind et al., Göttingen, Germany. In Int J Oncol, 2004
Up-regulated expression of mammary tumor 8 kDa protein (MAT-8), complement component C1S (C1S), ferritin heavy chain (FTH1), peptidyl-prolyl cis-trans isomerase A (PPIA), RNA-binding protein regulatory subunit DJ-1 protein (DJ-1) and vacuolar ATP synthase subunit F (ATP6V1F) was determined in prostate carcinoma and confirmed by using quantitative real-time RT-PCR analyses.
Biochemical support for the V-ATPase rotary mechanism: antibody against HA-tagged Vma7p or Vma16p but not Vma10p inhibits activity.
Nelson et al., Tel Aviv-Yafo, Israel. In J Exp Biol, 2003
Towards this end we used HA to tag subunits Vma7p, Vma10p and Vma16p, which are assumed to represent, respectively, the shaft, stator and turbine of the enzyme, and used them to supplement the corresponding yeast V-ATPase null mutants.
Expression, purification and secondary structure analysis of Saccharomyces cerevisiae vacuolar membrane H+-ATPase subunit F (Vma7p).
Harrison et al., Leeds, United Kingdom. In Mol Membr Biol, 2001
One example is subunit F, the Vma7p polypeptide of Saccharomyces cerevisiae.
Trypanosoma cruzi: a putative vacuolar ATP synthase subunit and a CAAX prenyl protease-encoding gene, as examples of gene identification in genome projects.
Andersson et al., Uppsala, Sweden. In Exp Parasitol, 2000
The first ORF (402 bp) showed homology to a 14-kDa vacuolar ATP synthase subunit F from a variety of organisms, such as yeast, rat, bovine, human, and a number of prokaryotes.
V1-situated stalk subunits of the yeast vacuolar proton-translocating ATPase.
Klionsky et al., Davis, United States. In J Biol Chem, 1997
Interactions between Vma7p (F) and Vma8p (D) and between Vma4p (E) and Vma10p (G) are described.
Resolution of subunit interactions and cytoplasmic subcomplexes of the yeast vacuolar proton-translocating ATPase.
Klionsky et al., Davis, United States. In J Biol Chem, 1996
We designate the large complex seen in wild-type cells containing at least subunits Vma1p, Vma2p, Vma4p, Vma7p, and Vma8p as the definitive V1 complex.
VMA7 encodes a novel 14-kDa subunit of the Saccharomyces cerevisiae vacuolar H(+)-ATPase complex.
Stevens et al., Eugene, United States. In J Biol Chem, 1994
We have characterized a novel 14-kDa V-ATPase subunit (Vma7p), encoded by the VMA7 gene, which exhibits features common to both V1 and V0 subunit proteins.
The Saccharomyces cerevisiae VMA7 gene encodes a 14-kDa subunit of the vacuolar H(+)-ATPase catalytic sector.
Nelson et al., Nutley, United States. In J Biol Chem, 1994
The gene VMA7 encodes a protein Vma7p of about 14 kDa.
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