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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.


The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: fibronectin, CAN, ACID, Plasminogen, V1a
Papers using vitronectin antibodies
Methods for quantifying follicular numbers within the mouse ovary.
Escriva Hector, In PLoS ONE, 2003
... Vitronectin was purchased from BD Biosciences.
Palmitoylation supports assembly and function of integrin–tetraspanin complexes
Hemler Martin E. et al., In The Journal of Cell Biology, 2001
... Laminin-5 was a gift (Desmos Inc., San Diego, CA) and vitronectin was purchased from Becton Dickinson.
Phosphatidylserine (PS) induces PS receptor-mediated macropinocytosis and promotes clearance of apoptotic cells.
Ryffel Bernhard, In PLoS ONE, 2000
... Antibodies to the following antigens were used: human vitronectin (VN58-1, mouse, Abcam, Cambridge, MA, USA), human ...
Papers on vitronectin
Comparative Characterization of Vaginal Cells Derived From Premenopausal Women With and Without Severe Pelvic Organ Prolapse.
Shynlova et al., Toronto, Canada. In Reprod Sci, Feb 2016
Primary vaginal cells were isolated by enzymatic digestion and characterized by immunocytochemistry. Cell attachment and proliferation on different matrices (collagen I, collagen II, collagen IV, fibronectin, laminin, tenascin, and vitronectin) were compared between POP-HVCs and control-HVCs.
Vitronectin: a promising breast cancer serum biomarker for early diagnosis of breast cancer in patients.
Huang et al., Beijing, China. In Tumour Biol, Feb 2016
In the present study, we determined serum levels of vitronectin (VN) in 93 breast cancer patients, 30 benign breast lesions, 9 precancerous lesions, and 30 healthy individuals by enzyme-linked immunosorbent assays.
β1,6-branched complex-type N-glycans affect FAK signaling in metastatic melanoma cells.
Lityńska et al., Kraków, Poland. In Cancer Invest, Feb 2016
Using WM266-4 cells with overexpression of β1,6-acetylglucosaminyltransferase V, we showed that β1,6-branched N-glycans increased tyrosine phosphorylation of FAK in metastatic melanoma cells, resulting in enhanced migration on vitronectin (VN).
EGFRvIII/integrin β3 interaction in hypoxic and vitronectinenriching microenvironment promote GBM progression and metastasis.
Ren et al., Harbin, China. In Oncotarget, Jan 2016
Our in vitro data demonstrated further enhanced EGFRvIII activity and tumor cell invasion in the tumor microenvironment of hypoxia plus extracellular matrix (ECM) vitronectin, in which EGFRvIII and integrin β3 tended to form complexes.
Interleukin-33 and Mast Cells Bridge Innate and Adaptive Immunity: From the Allergologist's Perspective.
Kim et al., Inch'ŏn, South Korea. In Int Neurourol J, Sep 2015
IL-33 promotes the adhesion of mast cells to laminin, fibronectin, and vitronectin.
A photoreversible protein-patterning approach for guiding stem cell fate in three-dimensional gels.
Tirrell et al., Pasadena, United States. In Nat Mater, May 2015
By using this approach to pattern the presentation of the extracellular matrix protein vitronectin, we accomplished reversible differentiation of human mesenchymal stem cells to osteoblasts in a spatially defined manner.
[Subcortical ischemic vascular dementia: lesson from hereditary cerebral small vessel disease].
Mizuno, Kyoto, Japan. In Brain Nerve, Apr 2015
Pathological examination of a CADASIL brain indicated abnormal accumulation of the extracellular domain of Notch3 with extracellular matrix proteins, including tissue inhibitor of metalloproteinase 3 and vitronectin, around vascular smooth muscle cells.
Role of tyrosine-sulfated proteins in retinal structure and function.
Al-Ubaidi et al., Oklahoma City, United States. In Exp Eye Res, Apr 2015
Research has identified four tyrosine-sulfated retinal proteins: fibulin 2, vitronectin, complement factor H (CFH), and opticin.
PTP1B triggers integrin-mediated repression of myosin activity and modulates cell contractility.
Arregui et al., Buenos Aires, Argentina. In Biol Open, 2014
Using PTP1B null (KO) cells and PTP1B reconstituted (WT) cells, we determined that some early steps following cell adhesion to fibronectin and vitronectin occurred robustly in WT cells, including aggregation of β3 integrins and adaptor proteins, and activation of Src/FAK-dependent signalling at small puncta in a lamellipodium.
Age-related macular degeneration and Alzheimer disease.
Çekiç et al., In Turk J Med Sci, 2014
Alzheimer disease and age-related macular degeneration share common features such as vitronectin and amyloid-β accumulation, increased oxidative stress, and apolipoprotein and complement activation pathways, which are reviewed as histologic and immunologic common features.
Thyroid Hormone, Hormone Analogs, and Angiogenesis.
Mousa et al., Albany, United States. In Compr Physiol, 2014
From αvβ3, the hormone directs transcription of specific vascular growth factor genes, regulates growth factor receptor/growth factor interactions and stimulates endothelial cell migration to a vitronectin cue; these actions are implicated experimentally in tumor-relevant angiogenesis and angioproliferative pulmonary hypertension.
[Clinical investigation of a Chinese family with hypotrichosis simplex of the scalp and mutational analysis of CDSN gene].
Quan et al., Huaihua, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2012
A nonsense mutation (C717G) in cDNA sequence of the CDSN gene was identified in all three patients of the family.
Vitronectin inhibits neutrophil apoptosis through activation of integrin-associated signaling pathways.
Abraham et al., Birmingham, United States. In Am J Respir Cell Mol Biol, 2012
ability of vitronectin to enhance neutrophil viability was dependent on activation of phosphatidylinositol 3-kinase and extracellular signal-regulated kinase 1/2 kinases, but not on the p38 kinase
Meningococcal surface fibril (Msf) binds to activated vitronectin and inhibits the terminal complement pathway to increase serum resistance.
Virji et al., Bristol, United Kingdom. In Mol Microbiol, 2011
In this study, the authors demonstrate meningococcal interactions with vitronectin via a novel adhesin, Msf (meningococcal surface fibril, previously NhhA or Hsf).
Vitronectin increases vascular permeability by promoting VE-cadherin internalization at cell junctions.
Wu et al., China. In Plos One, 2011
VN plays a previously unrecognized role in regulating endothelial permeability via conformational- and integrin-dependent effects on VE-cadherin trafficking.
Chemically defined conditions for human iPSC derivation and culture.
Thomson et al., Madison, United States. In Nat Methods, 2011
Using this new medium (E8) and vitronectin-coated surfaces, we demonstrate improved derivation efficiencies of vector-free human iPSCs with an episomal approach.
Association of -619C/T polymorphism in CDSN gene and psoriasis risk: a meta-analysis.
Li et al., Shenyang, China. In Genet Mol Res, 2010
CDSN -619C/T polymorphism may not be associated with susceptibility to psoriasis.
Combinatorial development of biomaterials for clonal growth of human pluripotent stem cells.
Anderson et al., Cambridge, United States. In Nat Mater, 2010
These analyses show that optimal human embryonic stem cell substrates are generated from monomers with high acrylate content, have a moderate wettability and employ integrin alpha(v)beta(3) and alpha(v)beta(5) engagement with adsorbed vitronectin to promote colony formation.
Regulation of cell signalling by uPAR.
Marshall et al., Montréal, Canada. In Nat Rev Mol Cell Biol, 2010
Integrins are essential uPAR signalling co-receptors and a second uPAR ligand, the ECM protein vitronectin, is also crucial for this process.
A Toll-like receptor 2-integrin beta3 complex senses bacterial lipopeptides via vitronectin.
de Diego et al., Berlin, Germany. In Nat Immunol, 2008
vitronectin and integrin beta(3) contribute to the initiation of TLR2 responses
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