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Visinin-like 1

VILIP-1, VILIP, Visinin-like protein-1, VSNL1, VLP1
This gene is a member of the visinin/recoverin subfamily of neuronal calcium sensor proteins. The encoded protein is strongly expressed in granule cells of the cerebellum where it associates with membranes in a calcium-dependent manner and modulates intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, VILIP-3, HAD, CsF, NVP2
Papers on VILIP-1
Proteome-wide identification of novel ceramide-binding proteins by yeast surface cDNA display and deep sequencing.
Liu et al., United States. In Mol Cell Proteomics, Feb 2016
Interestingly, four of the verified ceramide-binding proteins (HPCA, HPCAL1, NCS1, and VSNL1) and an additional three candidate ceramide-binding proteins (NCALD, HPCAL4, and KCNIP3) belong to the neuronal calcium sensor (NCS) family of EF hand-containing proteins.
Dysregulated miR-671-5p / CDR1-AS / CDR1 / VSNL1 axis is involved in glioblastoma multiforme.
Purrello et al., Catania, Italy. In Oncotarget, Jan 2016
Through a combined in silico and in vitro approach, we identified CDR1-AS, CDR1, VSNL1 as downstream miR-671-5p targets in GBM.
Longitudinal Cerebrospinal Fluid Biomarker Changes in Preclinical Alzheimer Disease During Middle Age.
Fagan et al., Gent, Belgium. In Jama Neurol, Sep 2015
Serial CSF samples were analyzed for β-amyloid 40 (Aβ40), Aβ42, total tau, tau phosphorylated at threonine 181 (P-tau181), visinin-like protein 1 (VILIP-1), and chitinase-3-like protein 1 (YKL-40).
Cerebrospinal Fluid Markers of Neurodegeneration and Rates of Brain Atrophy in Early Alzheimer Disease.
Holtzman et al., Saint-Louis, Senegal. In Jama Neurol, Jun 2015
Visinin-like protein 1 (VILIP-1) has demonstrated potential usefulness as a marker of neuronal injury in AD.
Visinin-like peptide 1 in adrenal gland of the rat. Gene expression and its hormonal control.
Rucinski et al., Poznań, Poland. In Peptides, 2015
VSNL1 encodes the calcium-sensor protein visinin-like 1 and was identified previously as an upregulated gene in a sample set of aldosterone-producing adenomas.
Evaluation of visinin-like protein 1 concentrations in the cerebrospinal fluid of patients with mild cognitive impairment as a dynamic biomarker of Alzheimer's disease.
Lewczuk et al., Białystok, Poland. In J Alzheimers Dis, 2014
BACKGROUND: The correlations between pathology of neurodegenerative diseases, especially Alzheimer's disease (AD), and concentrations of neuronal calcium sensor proteins, such as visinin-like protein 1 (VILIP-1), in cerebrospinal fluid (CSF) have been discussed in the literature but its utility as biomarker of AD in comparison with mild cognitive impairment (MCI) has not been studied yet.
Cerebrospinal fluid VILIP-1 and YKL-40, candidate biomarkers to diagnose, predict and monitor Alzheimer's disease in a memory clinic cohort.
Fagan et al., Amsterdam, Netherlands. In Alzheimers Res Ther, 2014
INTRODUCTION: We examined the utility of cerebrospinal fluid (CSF) proteins, Chitinase-3-like protein 1 (CHI3L1 or YKL-40), a putative marker of inflammation, and Visinin-like protein-1 (VILIP-1), a marker for neuronal injury, for diagnostic classification and monitoring of disease progression in a memory clinic cohort.
The Role of Visinin-Like Protein-1 in the Pathophysiology of Alzheimer's Disease.
Mroczko et al., Białystok, Poland. In J Alzheimers Dis, 2014
It has been revealed that NCS proteins, with special attention to visinin-like protein 1 (VILIP-1), might have a connection to the etiology of AD.
VSNL1 Co-Expression Networks in Aging Include Calcium Signaling, Synaptic Plasticity, and Alzheimer's Disease Pathways.
Sweet et al., Pittsburgh, United States. In Front Psychiatry, 2014
The visinin-like 1 (VSNL1) gene encodes visinin-like protein 1, a peripheral biomarker for Alzheimer disease (AD).
Serum visinin-like protein-1 in concussed professional ice hockey players.
Tegner et al., Mölndal, Sweden. In Brain Inj, 2014
PRIMARY OBJECTIVE: Visinin-like protein-1 (VILIP-1) has shown potential utility as a biomarker for neuronal injury in cerebrospinal fluid.
Specific interaction to PIP2 increases the kinetic rate of membrane binding of VILIPs, a subfamily of Neuronal Calcium Sensors (NCS) proteins.
Girard-Egrot et al., Villeurbanne, France. In Biochim Biophys Acta, 2014
The interaction of two members of this family, VILIP-1 and VILIP-3, with Langmuir monolayers as membrane models has been investigated in order to study the effects of both myristoylation and the highly basic region containing conserved poly-lysine residues on membrane association kinetics and binding properties.
Systematic analysis of gene expression and molecular interactions in cardiac and non-cardiac gastric carcinomas.
Yu et al., In Hepatogastroenterology, 2014
VSNL1 (visinin-like protein-1) is expressed relatively higher in the GNCA and could be its molecular biomarker, as KRT14 (cytokeratin 14) in the GCA.
Visinin-like 1 is upregulated in aldosterone-producing adenomas with KCNJ5 mutations and protects from calcium-induced apoptosis.
Mulatero et al., Torino, Italy. In Hypertension, 2012
VSNL1 may play a role in the pathophysiology of aldosterone-producing adenomas harboring mutations in the potassium channel KCNJ5 via its antiapoptotic function in response to calcium cytotoxicity and its effect on aldosterone production.
CSF VILIP-1 predicts rates of cognitive decline in early Alzheimer disease.
Holtzman et al., Saint Louis, United States. In Neurology, 2012
The findings suggest that CSF VILIP-1 and VILIP-1/Abeta42 predict rates of global cognitive decline similarly to tau and tau/Abeta42, and may be useful CSF surrogates for neurodegeneration in early Alzheimer disease.
The expression of Visinin-like 1 during mouse embryonic development.
Sariola et al., Helsinki, Finland. In Gene Expr Patterns, 2012
VSNL1 expresses exclusively in atrial cardiomyocytes during embryogenesis.
The putative tumor suppressor VILIP-1 counteracts epidermal growth factor-induced epidermal-mesenchymal transition in squamous carcinoma cells.
Braunewell et al., Berlin, Germany. In Plos One, 2011
Findings indicate that VILIP-1 is involved in epithelial-mesenchymal transition (EMT) of squamous cell carcinoma (SCC) cells by regulating the transcription factor Snail1 in a cAMP-dependent manner.
Visinin-like protein-1: diagnostic and prognostic biomarker in Alzheimer disease.
Holtzman et al., Saint Louis, United States. In Ann Neurol, 2011
Data suggest that CSF VILIP-1 and VILIP-1/Abeta42 offer diagnostic utility for early AD, and can predict future cognitive impairment in cognitively normal individuals similarly to tau and tau/Abeta42, respectively.
Visinin-like proteins (VSNLs): interaction partners and emerging functions in signal transduction of a subfamily of neuronal Ca2+ -sensor proteins.
Szanto et al., Birmingham, United States. In Cell Tissue Res, 2009
The visinin-like protein (VSNL) subfamily, including VILIP-1 (the founder protein), VILIP-2, VILIP-3, hippocalcin, and neurocalcin delta, constitute a highly homologous subfamily of neuronal calcium sensor (NCS) proteins.
Regulation of G protein-coupled receptor kinase subtypes by calcium sensor proteins.
De Blasi et al., Italy. In Biochim Biophys Acta, 2001
Several other recoverin homologues (including NCS 1, VILIP 1 and hippocalcin) are also able to inhibit GRK1.
Regulation of G-protein-coupled receptor kinase subtypes by calcium sensor proteins.
de Blasi et al., Italy. In Faseb J, 1999
Several other recoverin homologues (including NCS 1, VILIP 1, and hippocalcin) are also able to inhibit GRK1 in a calcium-dependent manner.
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