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VGF nerve growth factor inducible

peptide growth factor that plays a key role in neuronal differentiation and survival; may regulate synaptic function in hippocampal neurons [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Neuropeptide, fibrillin-1, ACID, CAN, V1a
Papers on VGF
Thyroid hormone and vitamin D regulate VGF expression and promoter activity.
Jethwa et al., Aberdeen, United Kingdom. In J Mol Endocrinol, Feb 2016
proVGF is one of the most abundant peptides in the mammalian brain, and studies have suggested a role for VGF-derived peptides in the photoperiodic regulation of body weight in the Siberian hamster.
Role of Hypothalamic VGF in Energy Balance and Metabolic Adaption to Environmental Enrichment in Mice.
Cao et al., Columbus, United States. In Endocrinology, Feb 2016
VGF, a peptide precursor particularly abundant in the hypothalamus, was upregulated by EE.
Protein expression in dairy cows with and without subclinical hypocalcaemia.
Liu et al., Daqing, China. In N Z Vet J, Dec 2015
Expression of serum albumin, fibrinogen alpha chain, amyloid beta A4 proteins and neurosecretory protein VGF were increased, and expression of apolipoprotein A-II and serum amyloid A proteins were decreased in the subclinical hypocalcaemic cows compared with control cows.
Diet-induced neuropeptide expression: feasibility of quantifying extended and highly charged endogenous peptide sequences by selected reaction monitoring.
Altelaar et al., Utrecht, Netherlands. In Anal Chem, Nov 2015
Using this approach to quantify endogenous peptide levels in hypothalami of animals subjected to different diets revealed several significant changes, most notably the significant upregulation of VGF-derived signaling peptide AQEE-30 upon high caloric feeding.
Neuroendocrine Role for VGF.
Jethwa et al., Loughborough, United Kingdom. In Front Endocrinol (lausanne), 2014
The vgf gene (non-acronymic) is highly conserved and was identified on the basis of its rapid induction in vitro by nerve growth factor, although can also be induced by brain-derived neurotrophic factor, and glial-derived growth factor.
Photoperiod Regulates vgf-Derived Peptide Processing in Siberian Hamsters.
Cocco et al., Monserrato, Italy. In Plos One, 2014
VGF mRNA is induced in specific hypothalamic areas of the Siberian hamster upon exposure to short photoperiods, which is associated with a seasonal decrease in appetite and weight loss.
Liver regeneration--the best kept secret. A model of tissue injury response.
Hernández-Lizoáin et al., In Rev Esp Enferm Dig, 2014
This process has been related with the tissue injury response regulators as: complement system, platelets, inflammatory cytokines(TNF-a, IL-1b, IL-6), growth factors (HGF, EGF, VGF) and anti-inflammatory factors (IL-10, TGF-b).Given its complexity and strict regulation, illustrates the unique alternative to liver failure is liver transplantation.The recent induced pluripotential cells (iPS) description and the mesenchymal stem cell (CD133+) plastic capability have aroused new prospects in the cellular therapy field.
[Research process of the neuropeptide VGF as a novel antidepressant regulatory factor].
Wang et al., Ningbo, China. In Nan Fang Yi Ke Da Xue Xue Bao, 2014
Studies have shown that the neuropeptide VGF participates in the regulation of hippocampal neurogenesis and neuroplasticity and also plays an important role in the regulation of neuronal proliferation and survival, suggesting that the neuropeptide VGF may be a novel regulator in antidepressant treatment.
Neuropeptides and central control of sexual behaviour from the past to the present: a review.
Melis et al., Cagliari, Italy. In Prog Neurobiol, 2013
However, evidence for a sexual role of gonadotropin-releasing hormone, corticotropin releasing factor, neuropeptide Y, galanin and galanin-like peptide, cholecystokinin, substance P, vasoactive intestinal peptide, vasopressin, angiotensin II, hypocretins/orexins and VGF-derived peptides are also available.
Granins and catecholamines: functional interaction in chromaffin cells and adipose tissue.
Bartolomucci et al., Santa Cruz de Tenerife, Spain. In Adv Pharmacol, 2012
Finally, we will provide an up-to-date review of the roles played by two granin-derived peptides, the chromogranin A-derived peptide catestatin and the VGF-derived peptide TLQP-21, on lipolysis and obesity.
A VGF-derived peptide attenuates development of type 2 diabetes via enhancement of islet β-cell survival and function.
Newgard et al., Durham, United States. In Cell Metab, 2012
Here we show that Nkx6.1 strongly upregulates the prohormone VGF in rat islets and that VGF is both necessary and sufficient for Nkx6.1-mediated
VGF: an inducible gene product, precursor of a diverse array of neuro-endocrine peptides and tissue-specific disease biomarkers.
Cocco et al., Cagliari, Italy. In J Chem Neuroanat, 2011
[review] The vgf gene is induced in vivo by neurotrophins including nerve growth factor (NGF), brain derived growth factor (BDNF) and glial derived growth actor (GDNF), by synaptic activity and by homeostatic and other stimuli.
The extended granin family: structure, function, and biomedical implications.
Salton et al., Minneapolis, United States. In Endocr Rev, 2011
The chromogranins (chromogranin A and chromogranin B), secretogranins (secretogranin II and secretogranin III), and additional related proteins (7B2, NESP55, proSAAS, and VGF) that together comprise the granin family subserve essential roles in the regulated secretory pathway that is responsible for controlled delivery of peptides, hormones, neurotransmitters, and growth factors.
Selective expression of TLQP-21 and other VGF peptides in gastric neuroendocrine cells and modulation by feeding.
Ferri et al., Cagliari, Italy. In J Endocrinol, 2010
Specific VGF peptides appear to be widely represented in different gastric endocrine and other mucosal cell populations.
Distribution of neuroendocrine regulatory peptide-1 and -2, and proteolytic processing of their precursor VGF protein in the rat.
Minamino et al., Suita, Japan. In J Neurochem, 2010
VGF protein is primarily cleaved at 10 sites through the processing pathway common to the brain and gastrointestinal tract.
The neuropeptide VGF is reduced in human bipolar postmortem brain and contributes to some of the behavioral and molecular effects of lithium.
Alder et al., United States. In J Neurosci, 2010
VGF is downregulated in bipolar disorder in the CA region of the hippocampus and Brodmann's area 9 of the prefrontal cortex.
An inducer of VGF protects cells against ER stress-induced cell death and prolongs survival in the mutant SOD1 animal models of familial ALS.
Hara et al., Gifu, Japan. In Plos One, 2009
VGF is regulated by SOD1 and plays a critical role in motor neuron survival
Antidepressant actions of the exercise-regulated gene VGF.
Duman et al., New Haven, United States. In Nat Med, 2007
the exercise-regulated gene VGF has an antidepressant effect
Epithelial wound healing enhanced by transforming growth factor-alpha and vaccinia growth factor.
Todaro et al., In Science, 1987
Transforming growth factor-alpha (TGF-alpha) and vaccinia growth factor (VGF) have substantial sequence homology with EGF, and all appear to bind to the same receptor protein.
Epidermal growth factor receptor occupancy inhibits vaccinia virus infection.
Nestor et al., In Nature, 1986
Vaccinia virus encodes VGF, an early protein of relative molecular mass 19,000 (19K) which, from amino-acid residues 45 to 85, is homologous in 19 residues to epidermal growth factor (EGF), and transforming growth factor-alpha (TGF-alpha).
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