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Lin-7 homolog C

Veli3, MALS-3, Lin-7C, Veli3 protein
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Top mentioned proteins: PSD-95, Stardust, NF90, fibrillin-1, NKp30
Papers on Veli3
Association analysis of BMD-associated SNPs with knee osteoarthritis.
Jackson et al., Baltimore, United States. In J Bone Miner Res, 2014
(LRP5), and 11p14.1 (LIN7C).
Identification of genomic regions associated with feed efficiency in Nelore cattle.
Regitano et al., São Carlos, Brazil. In Bmc Genet, 2013
Among the positional candidate genes selected for feed efficiency are: HRH4, ALDH7A1, APOA2, LIN7C, CXADR, ADAM12 and MAP7.
Suppression of metastasis by mirtazapine via restoration of the Lin-7C/β-catenin pathway in human cancer cells.
Tanzawa et al., Chiba, Japan. In Sci Rep, 2013
We reported previously that down-regulation of Lin-7C is essential for metastasis of human squamous cell carcinomas (hSCCs).
miR-199a-5p regulates urothelial permeability and may play a role in bladder pain syndrome.
Burkhard et al., Bern, Switzerland. In Am J Pathol, 2013
miR-199a-5p directly targets mRNAs encoding LIN7C, ARHGAP12, PALS1, RND1, and PVRL1 and attenuates their expression levels to a similar extent.
Calcium channel-dependent molecular maturation of photoreceptor synapses.
Haverkamp et al., Frankfurt am Main, Germany. In Plos One, 2012
Other proteins, such as Veli3 and PSD-95, also display abnormal expression in rods prior to eye opening.
Apico-basal polarity in polycystic kidney disease epithelia.
Wilson, London, United Kingdom. In Biochim Biophys Acta, 2011
Abnormalities in structural AJ, FA and polarity complexes in ADPKD epithelia include loss of E-cadherin, and focal adhesion kinase (FAK), MALS-3, Crb and Dlg complexes as well as disruptions in Rab/sec and syntaxin trafficking and membrane docking pathways.
11p14.1 microdeletions associated with ADHD, autism, developmental delay, and obesity.
Beaudet et al., Houston, United States. In Am J Med Genet A, 2011
The deletions encompass the BDNF and LIN7C genes that are implicated in the regulation of development and differentiation of neurons and synaptic transmission.
Structural basis for tandem L27 domain-mediated polymerization.
Shen et al., Tianjin, China. In Faseb J, 2010
The Dlg1-MPP7-Mals3 heterotrimer consists of 2 pairs of heterodimeric L27 domains. These 2 dimers are asymmetric due to the large difference between the N- and C-terminal tandem L27 domain of MPP7.
Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese.
Ma et al., Hong Kong, Hong Kong. In J Clin Endocrinol Metab, 2010
RESEARCH DESIGN AND METHODS: We examined 14 associated single-nucleotide polymorphisms at 12 loci (NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15) in 605 healthy adults, 1087 healthy adolescents and 6013 T2D patients from Hong Kong.
CASK deletion in intestinal epithelia causes mislocalization of LIN7C and the DLG1/Scrib polarity complex without affecting cell polarity.
Walther et al., New Haven, United States. In Mol Biol Cell, 2009
Data show that CASK expression and the appropriate localization of DLG1 and LIN7c are not essential for either epithelial polarity or intestinal homeostasis in vivo.
TMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals.
Schulz et al., Regensburg, Germany. In J Neurosci, 2009
TMEM16B colocalizes with adaptor proteins PSD95, VELI3, and MPP4 at the ribbon synapses and contains a consensus PDZ class I binding motif capable of interacting with PDZ domains of PSD95.
Proteomic analysis of the membrane palmitoylated protein-4 (MPP4)-associated protein complex in the retina.
Stöhr et al., Regensburg, Germany. In Exp Eye Res, 2009
Among the identified molecules were previously reported proteins of the MPP4 scaffolding complex including adaptor proteins Veli3 and Psd95.
Association study of brain-derived neurotrophic factor (BDNF) and LIN-7 homolog (LIN-7) genes with adult attention-deficit/hyperactivity disorder.
Muglia et al., Toronto, Canada. In Am J Med Genet B Neuropsychiatr Genet, 2008
Allelic and haplotype association was found between both BDNF and adult ADHD, and LIN-7 and adult ADHD.
MALS-3 regulates polarity and early neurogenesis in the developing cerebral cortex.
McConnell et al., Stanford, United States. In Development, 2008
MALS-3 plays a role in maintaining apicobasal polarity and is required for normal neurogenesis in the developing cortex.
Association study of theta EEG asymmetry and brain-derived neurotrophic factor gene variants in childhood-onset mood disorder.
Kennedy et al., Toronto, Canada. In Neuromolecular Med, 2007
METHODS: Theta EEG asymmetry measures were calculated for a total of 191 individuals with COMD and 93 controls, who were also genotyped at seven BDNF single-nucleotide polymorphism (SNPs), two intergenic flanking SNPs, and one SNP in the lin-7 homolog C (Caenorhabditis elegans) (LIN7C) gene.
Lin-7C/VELI3/MALS-3: an essential component in metastasis of human squamous cell carcinoma.
Tanzawa et al., Chiba, Japan. In Cancer Res, 2007
Overexpression of the Lin-7C gene in an OSCC cell clone does not contribute to underproliferation but results in a noninvasive phenotype with elevated beta-catenin expression.
Renal defects associated with improper polarization of the CRB and DLG polarity complexes in MALS-3 knockout mice.
Bredt et al., San Francisco, United States. In J Cell Biol, 2007
MALS-3 mediates stable assembly of the crumbs tight junction complex and the discs large basolateral complex, and these complexes are disrupted in renal epithelia from MALS-3 knockout mice.
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