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Lin-7 homolog B

Veli-2, MALS-2, Lin-7B, hLin-7b
one of several homologs of C.elegans lin-7; localizes to junctional complexes and synaptic junctions; may play a role in formation of cell-cell junctions [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: ACID, NKp30, PSD-95, V1a, Veli3
Papers on Veli-2
Role of an adaptor protein Lin-7B in brain development: possible involvement in autism spectrum disorders.
Nagata et al., Kasugai, Japan. In J Neurochem, 2015
Since LIN7B encodes a scaffold protein essential for neuronal function, we analyzed the role of Lin-7B in the development of cerebral cortex.
Genome-wide methylation profiling of schizophrenia.
Toncheva et al., Sofia, Bulgaria. In Balkan J Med Genet, 2014
We found new candidate genes that principally participate in apoptosis, synaptic transmission and nervous system development (GABRA2, LIN7B, CASP3).
Embryonic ionizing radiation exposure results in expression alterations of genes associated with cardiovascular and neurological development, function, and disease and modified cardiovascular function in zebrafish.
Nie et al., West Lafayette, United States. In Front Genet, 2013
Strong correlation between microarray and qPCR expression values was observed, but zebrafish exposed to 1 or 2 Gy resulted in a significant expression alteration in only one of these genes (LIN7B).
Decreased Lin7b expression in layer 5 pyramidal neurons may contribute to impaired corticostriatal connectivity in huntington disease.
Luthi-Carter et al., Freiburg, Germany. In J Neuropathol Exp Neurol, 2010
Data suggest that decreased cortical LIN7b expression may contribute to abnormal corticostriatal connectivity in Huntington disease.
Microarray analysis of gene expression in the ovarian cancer cell line HO-8910 with silencing of the ZNF217 gene.
Zhong et al., China. In Mol Med Report, 2009
Among these down-regulated genes were ALOX15, CD1D, FXYD3, GAS6, KRT4, LIN7B, MMP-24, PDZK1, PEX6, PRSS8, SLC2A9, STRN and WFDC2.
Association study of brain-derived neurotrophic factor (BDNF) and LIN-7 homolog (LIN-7) genes with adult attention-deficit/hyperactivity disorder.
Muglia et al., Toronto, Canada. In Am J Med Genet B Neuropsychiatr Genet, 2008
Allelic and haplotype association was found between both BDNF and adult ADHD, and LIN-7 and adult ADHD.
Altered gene expression in the superior temporal gyrus in schizophrenia.
Tooney et al., Sydney, Australia. In Bmc Genomics, 2007
To confirm altered expression identified by microarray analysis, the mRNA expression levels of four genes, IPLA2gamma, PIK31R1, Lin-7b and ATBF1, were semi-quantitatively measured using relative real-time PCR.
Identification of a cell polarity-related protein, Lin-7B, as a binding partner for a Rho effector, Rhotekin, and their possible interaction in neurons.
Nagata et al., Kasugai, Japan. In Neurosci Res, 2006
Lin-7B is a binding partner for Rhotekin in the human brain cDNA library
Ggamma13 interacts with PDZ domain-containing proteins.
Margolskee et al., New York City, United States. In J Biol Chem, 2006
We identified PSD95, Veli-2, and other PDZ domain-containing proteins as binding partners for Ggamma13 by yeast two-hybrid and pull-down assays.
PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current.
Welsh et al., Iowa City, United States. In J Biol Chem, 2004
PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current
A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels.
Vandenberg et al., Santa Barbara, United States. In J Biol Chem, 2004
specific Veli isoforms participate in forming distinct protein complexes in brain, where Veli-1 stably associates with CASK and SAP97, Veli-2 associates with CASK and Mint1, and Veli-3 associates with CASK, SAP97, and Mint1.
Differential modulation of NR1-NR2A and NR1-NR2B subtypes of NMDA receptor by PDZ domain-containing proteins.
Inui et al., Ube, Japan. In J Neurochem, 2004
The effects of MALS-2 and PSD-95 on the channel activity of NMDA receptors were compared using the Xenopus oocyte expression system.
Identification and characterization of human MPP7 gene and mouse Mpp7 gene in silico.
Katoh et al., Narashino, Japan. In Int J Mol Med, 2004
MPP7 was most related to MPP3 among MPP family members, functioning as adopter molecules assembling Crb homologs (CRB1, CRB3), Dlt homologs (INADL/PATJ, MPDZ/MUPP1), and Lin-7 homologs (LIN7A, LIN7B, LIN7C).
Identification and characterization of human PPFIA4 gene in silico.
Katoh et al., Narashino, Japan. In Int J Mol Med, 2003
which was also paralogous to PPFIA3-LIN7B locus (19q13.41).
The expression of the PDZ protein MALS-1/velis is regulated by calcium and calcineurin in cerebellar granule cells.
Genazzani et al., Cambridge, United Kingdom. In J Biol Chem, 2003
We hereby report that in cultured cerebellar granule cells the activation of the Ca(2+)/calcineurin pathway via either voltage- or ligand- operated Ca(2+) channels regulates MALS-1 and MALS-2 expression at the transcriptional level.
Basolateral membrane expression of the Kir 2.3 channel is coordinated by PDZ interaction with Lin-7/CASK complex.
Welling et al., Baltimore, United States. In Am J Physiol Cell Physiol, 2002
Here, we identify a new human ortholog of a Caenorhabditis elegans PDZ protein, hLin-7b, that interacts with the COOH-terminal tail of Kir 2.3 in renal epithelia.
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