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Voltage-dependent anion channel 2

VDAC2, Voltage-Dependent Anion Channel 2
This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: VDAC1, VDAC3, fibrillin-1, CAN, V1a
Papers using VDAC2 antibodies
The mitochondrial permeability transition, release of cytochrome c and cell death. Correlation with the duration of pore openings in situ.
Koch Karl-Wilhelm, In PLoS ONE, 2000
... anti VDAC1 antibody was from Abcam, (Cambridge, UK); the goat polyclonal anti HK II, anti VDAC2 and anti ANT antibodies and the mouse monoclonal anti GSK-3 antibody were from Santa Cruz Biotechnology (Santa Cruz, CA); the ...
Papers on VDAC2
Role of hexokinase and VDAC in neurological disorders.
de Cerqueira César et al., Pirassununga, Brazil. In Curr Mol Pharmacol, Feb 2016
Moreover VDAC1 expression level is elevated in cerebellum of patients with Down ´s syndrome, while in Alzheimer ´s disease, VDAC1 levels are decreased in frontal cortex and VDAC2 elevated in temporal cortex.
VDAC-2: Mitochondrial outer membrane regulator masquerading as a channel?
Mahalakshmi et al., Bhopāl, India. In Febs J, Jan 2016
Although VDAC-1 has an established role in apoptosis and cell homeostasis, the role of VDAC-2 has been controversial.
N-helix and Cysteines Inter-regulate Human Mitochondrial VDAC-2 Function and Biochemistry.
Mahalakshmi et al., Bhopāl, India. In J Biol Chem, Jan 2016
Human voltage-dependent anion channel-2 (hVDAC-2) functions primarily as the crucial anti-apoptotic protein in the outer mitochondrial membrane, and additionally as a gated bidirectional metabolite transporter.
Characterization of Oyster Voltage-Dependent Anion Channel 2 (VDAC2) Suggests Its Involvement in Apoptosis and Host Defense.
Zhang et al., Beijing, China. In Plos One, Dec 2015
In this study, we focused on a representative apoptotic gene encoding voltage-dependent anion channel 2 (VDAC2), a porin that abounds at the mitochondrial outer membrane.
Identification of Novel Biomarker and Therapeutic Target Candidates for Diagnosis and Treatment of Follicular Adenoma.
Chen et al., Indianapolis, United States. In Cancer Genomics Proteomics, Dec 2015
A comprehensive approach to prioritize the biomarker candidates by category and rank revealed CD63, DDB1, TYMP, VDAC2, and DCXR as the top five biomarker candidates.
Motifs of VDAC2 required for mitochondrial Bak import and tBid-induced apoptosis.
Hajnóczky et al., Budapest, Hungary. In Proc Natl Acad Sci U S A, Nov 2015
However, only Vdac2(-/-) (V2(-/-)) mice are embryonic lethal, indicating a unique and fundamental function of VDAC2 (V2).
Succination is increased on select proteins in the brainstem of the Ndufs4 knockout mouse, a model of Leigh syndrome.
Frizzell et al., United States. In Mol Cell Proteomics, Nov 2015
Using targeted mass spectrometry, Cys77 and Cys48 were identified as endogenous sites of succination in VDAC2.
Moonlighting proteins in sperm-egg interactions.
Auer et al., In Biochem Soc Trans, 2014
We identified proteins already described in human spermatozoa, but implicated in different metabolic pathways such as glycolytic enzymes [phosphokinase type 3 (PK3), enolase 1 (ENO1), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), aldolase A (ALDOA) and triose phosphate isomerase (TPI)], detoxification enzymes [GST Mu (GSTM) and phospholipid hydroperoxide glutathione peroxidase (PHGPx) 4], ion channels [voltage-dependent anion channel 2 (VDAC2)] or structural proteins (outer dense fibre 2).
VDAC2 involvement in the stress response pathway in Arabidopsis thaliana.
Yang et al., Chengdu, China. In Genet Mol Res, 2014
In this study, we explored the role of Arabidopsis thaliana VDAC2 (AtVDAC2) in the signal transduction pathway in Arabidopsis under salt stress.
VDAC phosphorylation, a lipid sensor influencing the cell fate.
Brenner et al., Montréal, Canada. In Mitochondrion, 2014
In the recent past, major efforts focused on VDAC1 channel function and regulation by calcium and reactive oxygen species, and comparatively, fewer studies have been undertaken on VDAC2 and 3 and their pathophysiological involvement.
Warburg revisited: regulation of mitochondrial metabolism by voltage-dependent anion channels in cancer cells.
Lemasters et al., Charleston, United States. In J Pharmacol Exp Ther, 2012
Knockdown of different VDAC isoforms, especially of the least abundant isoform, VDAC3, also decreases ΔΨ(m), cellular ATP, and NADH/NAD+, suggesting that VDAC1 and VDAC2 are most inhibited by free tubulin.
Critical role for voltage-dependent anion channel 2 in infectious bursal disease virus-induced apoptosis in host cells via interaction with VP5.
Zheng et al., Beijing, China. In J Virol, 2012
VP5-induced apoptosis during IBDV infection is mediated by interacting with VDAC2, a protein that appears to restrict viral replication via induction of cell death
Proteomic data in meningiomas: post-proteomic analysis can reveal novel pathophysiological pathways.
Whittle et al., Edinburgh, United Kingdom. In J Neurooncol, 2011
Western blot analyses of meningioma tissue provided a measure of support for a core component in the network (involving VDAC2, APOA1 and HNF4α) but highlighted intrinsic difficulty of proteomic and biochemical analysis of meningiomas (as a consequence of gross alterations in tissue composition).
Effects of intracellular zinc depletion on the expression of VDAC in cultured hippocampal neurons.
Jiang et al., Chengdu, China. In Nutr Neurosci, 2011
Up-regulation of VDAC1 and down-regulation of VDAC2 may participate in hippocampal neuron injury induced by zinc deficiency.
Voltage-dependent anion channel 2 modulates resting Ca²+ sparks, but not action potential-induced Ca²+ signaling in cardiac myocytes.
Woo et al., Taejŏn, South Korea. In Cell Calcium, 2011
VDAC2 may facilitate mitochondrial Ca(2+) uptake and restrict Ca(2+) spark expansion without regulating activations of sparks under resting conditions.
Analysis and difference of voltage-dependent anion channel mRNA in ejaculated spermatozoa from normozoospermic fertile donors and infertile patients with idiopathic asthenozoospermia.
Zhang et al., Nanjing, China. In J Assist Reprod Genet, 2010
The high abundance of VDAC2 mRNA seemed to have a positive correlation with low sperm motility in male infertility with idiopathic asthenozoospermia.
The use of anti-VDAC2 antibody for the combined assessment of human sperm acrosome integrity and ionophore A23187-induced acrosome reaction.
Zhang et al., Nanjing, China. In Plos One, 2010
distribution and function of VDAC2 in human spermatozoa
RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels.
Stockwell et al., New York City, United States. In Nature, 2007
RNA-interference-mediated knockdown of VDAC2 or VDAC3 caused resistance to erastin, implicating these two VDAC isoforms in the mechanism of action of erastin.
Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death.
Molkentin et al., Cincinnati, United States. In Nat Cell Biol, 2007
Vdacs are dispensable for both MPT and Bcl-2 family member-driven cell death.
VDAC2 inhibits BAK activation and mitochondrial apoptosis.
Korsmeyer et al., Boston, United States. In Science, 2003
VDAC2 regulates the activity of BAK and provides a connection between mitochondrial physiology and the core apoptotic pathway
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