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Vanin 3

vanin-3, VNN3
This gene is the central gene in a cluster of three vanin genes on chromosome 6q23-q24. The open reading frame is disrupted by a frameshift, and all splice variants that have been described are candidates for nonsense-mediated decay (NMD). Consequently, it is unlikely that this gene expresses a protein in vivo, so it is classified as a pseudogene. Extensive alternative splicing has been described; the two most common variants are represented as RefSeqs. [provided by RefSeq, Aug 2009] (from NCBI)
Top mentioned proteins: V-I, POLYMERASE, SET, ACID, HAD
Papers on vanin-3
Assessment and diagnostic relevance of novel serum biomarkers for early decision of ST-elevation myocardial infarction.
Nam et al., Seoul, South Korea. In Oncotarget, Jun 2015
Data suggested that PGLYRP1, IRAK3 and VNN3 are more specific and sensitive diagnostic biomarkers for STEMI than traditional CK-MB or troponin.Blood transcriptome scans of ACS evidenced early stage molecular markers for STEMI.
Pharmacologic concentrations of melatonin have diverse influence on differential expressions of angiogenic chemokine genes in different hepatocellular carcinoma cell lines.
Chuang et al., Kao-hsiung, Taiwan. In Biomed Pharmacother, 2010
Two genes related to oxidative stress (SOD2, VNN3) were also studied.
Detection of rare variant effects in association studies: extreme values, iterative regression, and a hybrid approach.
Zhang et al., United States. In Bmc Proc, 2010
The powers to detect VNN3 and BCHE are 34% and 30% for Q2, respectively.
Identifying variants that contribute to linkage for dichotomous and quantitative traits in extended pedigrees.
Rich et al., Charlottesville, United States. In Bmc Proc, 2010
We also identified four variants (including one at VNN3) on chromosome 6q that are able to drop the linkage LOD from 3.7 to 1.0.
Pharmacologic concentrations of ascorbic acid cause diverse influence on differential expressions of angiogenic chemokine genes in different hepatocellular carcinoma cell lines.
Chuang et al., Kao-hsiung, Taiwan. In Biomed Pharmacother, 2010
Three angiogenic genes (CCL2, CXCL6, IL8), one angiostatic gene (CXCL10) and two genes related to oxidative stress (SOD2, VNN3) were selected for quantitative RT-PCR study.
Molecular diagnostics of psoriasis, atopic dermatitis, allergic contact dermatitis and irritant contact dermatitis.
Schalkwijk et al., Nijmegen, Netherlands. In Br J Dermatol, 2010
Interleukin-1F9, elafin, beta-defensin-2 and vanin-3 were strongly induced in psoriasis, but not in any type of eczema.
Expression of the vanin gene family in normal and inflamed human skin: induction by proinflammatory cytokines.
Schalkwijk et al., Nijmegen, Netherlands. In J Invest Dermatol, 2009
vanin-1 and vanin-3 are induced at the mRNA and protein level by psoriasis-associated proinflammatory cytokines (Th17/Th1) but not by Th2 cytokines.
Alternative spliced variants in the pantetheinase family of genes expressed in human neutrophils.
Node et al., Yokohama, Japan. In Gene, 2009
The pantetheinase gene family consists of three independent genes, pantetheinase/vanin-1/VNN1, GPI-80/VNN2 and vanin-3/VNN3 that are each composed of seven exons.
Complex genetic control of susceptibility to malaria: positional cloning of the Char9 locus.
Gros et al., Montréal, Canada. In J Exp Med, 2007
Lack of pantetheinase protein activity in tissues is associated with susceptibility to malaria and is linked to a complex rearrangement in the Vnn3 promoter region.
Transcriptome analysis in blastocyst hatching by cDNA microarray.
Tzeng et al., Taipei, Taiwan. In Hum Reprod, 2005
These genes included: cell adhesion and migration molecules [E-cadherin, neuronal cell adhesion molecule (NCAM), lectin, galactose binding, soluble 7 (Lgals7), vanin 3 and biglycan], epigenetic regulators (Dnmt1, and SIN3 yeast homolog A), stress response regulators (heme oxygenase 1) and immunoresponse regulators [interleukin (IL)-2-inducible T-cell kinase, IL-4R, interferon-gamma receptor 2, and neurotrophin].
Vanin genes are clustered (human 6q22-24 and mouse 10A2B1) and encode isoforms of pantetheinase ectoenzymes.
Galland et al., Marseille, France. In Immunogenetics, 2001
This molecule is the prototypic member of a larger Vanin family encoded by at least two mouse (Vanin-1 and Vanin-3) and three human (VNN1, VNN2, VNN3) orthologous genes.
Metallothionein-null mice express altered genes during development.
Tanaka et al., Suita, Japan. In Biochem Biophys Res Commun, 2000
The sequences of the other cDNA fragments were identical to those of contrapsin, transketolase, and vanin-3.
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