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Valyl-tRNA synthetase

valyl-tRNA synthetase, G7a, Vars, ValRS, BAT6, VAS1
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. The protein encoded by this gene belongs to class-I aminoacyl-tRNA synthetase family and is located in the class III region of the major histocompatibility complex. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, STEP, Arginine Vasopressin
Papers on valyl-tRNA synthetase
Genes that Affect Brain Structure and Function Identified by Rare Variant Analyses of Mendelian Neurologic Disease.
Lupski et al., Houston, United States. In Neuron, Dec 2015
Among the candidate genes identified, we found PRUNE, VARS, and DHX37 in multiple families and homozygous loss-of-function variants in AGBL2, SLC18A2, SMARCA1, UBQLN1, and CPLX1.
Substrate-Assisted and Enzymatic Pretransfer Editing of Nonstandard Amino Acids by Methionyl-tRNA Synthetase.
Gauld et al., Windsor, Canada. In Biochemistry, Oct 2015
A similarly positioned aspartate or glutamate also occurs in the homologous enzymes LeuRS, IleRS, and ValRS, which also discriminate against Hcy.
Auxin and Tryptophan Homeostasis Are Facilitated by the ISS1/VAS1 Aromatic Aminotransferase in Arabidopsis.
Celenza et al., Boston, United States. In Genetics, Sep 2015
Indole-3-acetic acid (IAA) plays a critical role in regulating numerous aspects of plant growth and development.
Identification and characterization of intracellular proteins that bind oligonucleotides with phosphorothioate linkages.
Crooke et al., Carlsbad, United States. In Nucleic Acids Res, Apr 2015
Many of the tested proteins had no significant effect on ASO activity; however, some proteins, including La/SSB, NPM1, ANXA2, VARS and PC4, appeared to enhance ASO activities, likely through mechanisms related to subcellular distribution.
Role of AcsR in expression of the acetyl-CoA synthetase gene in Vibrio vulnificus.
Park et al., Seoul, South Korea. In Bmc Microbiol, 2014
BACKGROUND: VarS/VarA is one of the global factors regulating diverse aspects of the metabolism and virulence of bacteria including pathogenic Vibrio spp.
Evaluation of Multi-tRNA Synthetase Complex by Multiple Reaction Monitoring Mass Spectrometry Coupled with Size Exclusion Chromatography.
Lee et al., Seoul, South Korea. In Plos One, 2014
Moreover, other large complex-forming ARS proteins, such as VARS and FARS, were detected in earlier fractions.
Caenorhabditis elegans glp-4 Encodes a Valyl Aminoacyl tRNA Synthetase.
Schedl et al., Mishima, Japan. In G3 (bethesda), 2014
We determined that glp-4 encodes a valyl aminoacyl transfer RNA synthetase (VARS-2) and that the probable null phenotype is early larval lethality.
Vibrio cholerae CsrA Regulates ToxR Levels in Response to Amino Acids and Is Essential for Virulence.
Payne et al., Austin, United States. In Mbio, 2014
The VarS/VarA two-component system controls the amount of active CsrA, a small RNA-binding protein involved in the regulation of a wide range of cellular processes.
Three-dimensional reconstruction of the valyl-tRNA synthetase/elongation factor-1H complex and localization of the delta subunit.
Norcum et al., Jackson, United States. In Febs Lett, 2005
The first three-dimensional structure of the the valyl-tRNA synthetase/elongation factor-1H complex as calculated from electron microscopic images of negatively stained samples of the human ValRS/EF-1H complex was obtained.
Enlarging the amino acid set of Escherichia coli by infiltration of the valine coding pathway.
Marlière et al., Fontaine, France. In Science, 2001
All mutations obtained were located in the editing site of valyl-tRNA synthetase.
[Histocompatibility HLA system of man. Consideration in the light of current concepts. I. Organization and polymorphism].
Turowski et al., In Przegl Lek, 2000
The genes so far recognised in the HLA can be subdivided into three major classes: 1) the HLA class I (HLA-ABC) and class II genes (HLA-D); 2) immune function related genes (C2, C4A, C4B, TNFA and TNFB, transporter and proteasome genes); 3) other genes apparently not related to immune functions (CYP 21, valyl-tRNA synthetase).
Structural basis for double-sieve discrimination of L-valine from L-isoleucine and L-threonine by the complex of tRNA(Val) and valyl-tRNA synthetase.
Yokoyama et al., Tokyo, Japan. In Cell, 2000
Valyl-tRNA synthetase (ValRS) strictly discriminates the cognate L-valine from the larger L-isoleucine and the isosteric L-threonine by the tRNA-dependent "double sieve" mechanism.
Characterization of two bifunctional Arabdopsis thaliana genes coding for mitochondrial and cytosolic forms of valyl-tRNA synthetase and threonyl-tRNA synthetase by alternative use of two in-frame AUGs.
Wintz et al., Strasbourg, France. In Eur J Biochem, 1999
class I valyl-tRNA synthetase and class II threonyl-tRNA synthetase genes encode the cytosolic and mitochondrial forms of the enzymes by alternative use of two in-frame initiation codons.
Multiple phosphorylation sites and quaternary organization of guanine-nucleotide exchange complex of elongation factor-1 (EF-1betagammadelta/ValRS) control the various functions of EF-1alpha.
Bellé et al., Saint-Pierre-des-Corps, France. In Biosci Rep, 1998
The eukaryotic guanine-nucleotide exchange factor commonly called elongation factor-1 betagammadelta (EF-1betagammadelta), comprises four different subunits including valyl-tRNA synthetase (EF-1betagammadelta/ValRS).
Phosphorylation of elongation factor-1 (EF-1) by cdc2 kinase.
Mulner-Lorillon et al., Paris, France. In Prog Cell Cycle Res, 1994
The guanine-nucleotide exchange factor EF-1 beta gamma delta, appears to have a highly complex macromolecular structure containing several GTP/GDP exchange proteins, valyl-tRNA synthetase, and a putative anchoring protein EF-1 gamma.
Partition of tRNA synthetases into two classes based on mutually exclusive sets of sequence motifs.
Moras et al., Strasbourg, France. In Nature, 1990
Out of the 18 known aaRS, only 9 referred to as class I synthetases (GlnRS, TyrRS, MetRS, GluRS, ArgRS, ValRS, IleRS, LeuRS, TrpRS), display two short common consensus sequences ('HIGH' and 'KMSKS') which indicate, as observed in three crystal structures, the presence of a structural domain (the Rossman fold) that binds ATP.
Reversible interconversion of two forms of a valyl-tRNA synthetase-containing protein complex.
Black, In Science, 1986
When an enzyme-containing complex from yeast was incubated in a buffered solution at room temperature, the valyl-transfer RNA synthetase activity and total protein oscillated synchronously between two physical states.
Bovine mannosidosis--a model lysosomal storage disease.
Winchester et al., In Birth Defects Orig Artic Ser, 1974
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