A role for V-ATPase subunits in synaptic vesicle fusion?
Marseille, France. In J Neurochem, 2011
A synaptic vesicle v-SNARE protein (VAMP2 or synaptobrevin), in association with two plasma membrane t-SNAREs (syntaxin 1 and SNAP25), assemble to form a protein complex that is largely accepted as the minimal membrane fusion machine.
[The role of docosahexaenoic acid in neuronal function].
Łódź, Poland. In Postepy Hig Med Dosw (online), 2010
DHA present in membrane phospholipids facilitates v-SNARE/t-SNARE complex formation, which is necessary for fusion of synaptic vesicles and plasma membranes necessary for transmitter exocytosis, and neurite outgrowth-dependent plasticity.
Role of SNAREs in membrane fusion.
Detroit, United States. In Adv Exp Med Biol, 2010
For example in cell secretion, target membrane proteins at the cell plasma membrane SNAP-25 and syntaxin termed t-SNAREs, and secretory vesicle-associated protein VAMP or v-SNARE, are part of the conserved protein complex involved in fusion of opposing membranes.
v-SNARE actions during Ca(2+)-triggered exocytosis.
Homburg, Germany. In Cell, 2007
These observations provide evidence that v-SNARE proteins drive Ca(2+)-triggered membrane fusion at millisecond time scale and support a model wherein continuous molecular pulling by SNAREs guides the vesicle throughout the consecutive stages of exocytosis.
TRP Channel Trafficking
Boca Raton, United States. In Unknown Journal, 0001
For instance, the interaction of the vesicle membrane SNARE (v-SNARE) synaptobrevin 2, and the corresponding SNAREs in the target membrane (t-SNAREs), syntaxin 1 and SNAP25, results in the formation of a remarkably stable ternary complex that ensures the docking and fusion of vesicles at the active zone upon receiving the stimulus, normally an increase in the intracellular concentration of Ca(2+) ([Ca ]i).(+5)