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Solute carrier family 14

UTA, UT2, Slc14a2, HUT2
The protein encoded by this gene belongs to the urea transporter family. In mammalian cells, urea is the chief end product of nitrogen catabolism, and plays an important role in the urinary concentration mechanism. This protein is expressed in the inner medulla of the kidney, and mediates rapid transepithelial urea transport across the inner medullary collecting duct. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: HAD, CAN, AGE, OUT, ACID
Papers using UTA antibodies
Human embryonic stem cell-derived cardiomyocytes: demonstration of a portion of cardiac cells with fairly mature electrical phenotype
Aalto-Setälä Katriina et al., In Stem Cells International, 2009
... ] and H7 (WiCell Research Institute) and the human iPS cell lines UTA.00106 and UTA.00112 (derived at the Institute of Biomedical technology, IBT, University of ...
Papers on UTA
Genetic subdivision and candidate genes under selection in North American grey wolves.
Wayne et al., Los Angeles, United States. In Mol Ecol, Jan 2016
In several high-ranking candidate genes, including LEPR, TYR and SLC14A2, we found variation in allele frequencies that follow environmental changes in temperature and precipitation, a result that is consistent with local adaptation rather than genetic drift.
Endoscopic Ultrasound Estimates for Tumor Depth at the Gastroesophageal Junction Are Inaccurate: Implications for the Liberal Use of Endoscopic Resection.
Hofstetter et al., Houston, United States. In Ann Thorac Surg, Nov 2015
The EUS was accurate in the following: uT0 6% (1 of 18); uT1a 56% (23 of 41); uT1b 58% (41 of 71); uT2 10% (2 of 21); and uT3 70% (21 of 30).
Hypoxia, AMPK activation and uterine artery vasoreactivity.
Moore et al., Aurora, United States. In J Physiol, Jul 2015
ABSTRACT: Genes near adenosine monophosphate-activated protein kinase-α1 (PRKAA1) have been implicated in the greater uterine artery (UtA) blood flow and relative protection from fetal growth restriction seen in altitude-adapted Andean populations.
High salt-diet reduces SLC14A1 gene expression in the choroid plexus of Dahl salt sensitive rats.
Sun et al., Changchun, China. In Biochem Biophys Res Commun, Jun 2015
High salt intake (8%, for 2 weeks) did not alter the mRNA levels of UT-A (encoded by SLC14A2 gene) in the CP of either Dahl S or Dahl R rats.
First trimester screening for early and late preeclampsia based on maternal characteristics, biophysical parameters, and angiogenic factors.
Gratacós et al., Barcelona, Spain. In Prenat Diagn, Feb 2015
Data included the a priori risk (maternal characteristics), mean arterial pressure (MAP), and uterine artery (UtA) Doppler (11-13 weeks) in all cases.
Forms of Circulating Luteinizing Hormone Human Chorionic Gonadotropin Receptor for the Prediction of Early and Late Preeclampsia in the First Trimester of Pregnancy.
Gratacós et al., Barcelona, Spain. In Fetal Diagn Ther, 2014
We recorded/measured maternal characteristics, mean arterial pressure (MAP), uterine artery (UtA) Doppler, placental growth factor (PlGF), soluble Fms-like tyrosine kinase-1 (sFtl-1), and LHCGR forms (hCG-LHCGR and soluble LHCGR), and their independent predictive values were analyzed by logistic regression.
Transmembrane Inhibitor of RICTOR/mTORC2 in Hematopoietic Progenitors.
Scadden et al., Boston, United States. In Stem Cell Reports, 2014
Upstream of mTORC2 (UT2) negatively regulates mTORC2 enzymatic activity, reducing AKT(S473), PKCα, and NDRG1 phosphorylation and increasing FOXO transcriptional activity in an mTORC2-dependent manner.
N-acetylglucosamine-1-P uridylyltransferase 1 and 2 are required for gametogenesis and embryo development in Arabidopsis thaliana.
Cheng et al., Taipei, Taiwan. In Plant Cell Physiol, 2014
The single mutants glcna.ut1 and glcna.ut2
Genes and proteins of urea transporters.
Blount et al., Atlanta, United States. In Subcell Biochem, 2013
The SLC14a urea transporter family contains two major subgroups: SLC14a1, the UT-B urea transporter originally isolated from erythrocytes; and SLC14a2, the UT-A group originally isolated from kidney inner medulla.
The urea transporter family (SLC14): physiological, pathological and structural aspects.
Hediger et al., Bangkok, Thailand. In Mol Aspects Med, 2013
Urea transporters (UTs) belonging to the solute carrier 14 (SLC14) family comprise two genes with a total of eight isoforms in mammals, UT-A1 to -A6 encoded by SLC14A2 and UT-B1 to -B2 encoded by SLC14A1.
Molecular mechanisms of urea transport in health and disease.
Sands et al., Atlanta, United States. In Pflugers Arch, 2012
The existence of urea transport proteins were thus proposed and less than a decade later, the first urea transporter was cloned.
Glycoforms of UT-A3 urea transporter with poly-N-acetyllactosamine glycosylation have enhanced transport activity.
Chen et al., Atlanta, United States. In Am J Physiol Renal Physiol, 2012
The highly stable expression of highly glycosylated UT-A3 on the cell membrane in kidney inner medulla suggests that UT-A3 may have an important function in urea reabsorption.
Mature N-linked glycans facilitate UT-A1 urea transporter lipid raft compartmentalization.
Sands et al., Atlanta, United States. In Faseb J, 2011
new role of N-linked glycosylation in regulating UT-A1 activity by promoting UT-A1 trafficking into membrane lipid raft subdomains
The emerging physiological roles of the SLC14A family of urea transporters.
Stewart, Dublin, Ireland. In Br J Pharmacol, 2011
These proteins are derived from two distinct genes, UT-A (SLC14A2) and UT-B (SLC14A1).
Urea transport in the kidney.
Sands et al., Atlanta, United States. In Compr Physiol, 2011
Currently, the SLC14A family of urea transporters contains two major subgroups: SLC14A1, the UT-B urea transporter originally isolated from erythrocytes; and SLC14A2, the UT-A group with six distinct isoforms described to date.
UT-B1 mediates transepithelial urea flux in the rat gastrointestinal tract.
Stewart et al., Dublin, Ireland. In J Membr Biol, 2011
Study concluded that UT-B1 mediates the transepithelial movement of urea that occurs in specific distal regions of the rat gastrointestinal tract.
Genetic variants of human urea transporter-2 are associated with metabolic syndrome in Asian population.
Sheu et al., Taiwan. In Clin Chim Acta, 2011
HUT2 gene may play a certain role in developing metabolic syndrome and its related traits in Asian population.
Functional characterization of the central hydrophilic linker region of the urea transporter UT-A1: cAMP activation and snapin binding.
Fröhlich et al., Atlanta, United States. In Am J Physiol Cell Physiol, 2010
Suggest that responsiveness to vasopressin that observed with UT-A1 can be introduced into the unresponsive UT-A2 variant through the Lc segment that is unique to UT-A1. In UT-A3 the Lc segment plays no significant role in its activation by cAMP.
Undertaker, a Drosophila Junctophilin, links Draper-mediated phagocytosis and calcium homeostasis.
Franc et al., London, United Kingdom. In Cell, 2008
We report that Undertaker (UTA), a Drosophila Junctophilin protein, is required for Draper (CED-1 homolog)-mediated phagocytosis.
Cloning and characterization of the vasopressin-regulated urea transporter.
Hediger et al., Boston, United States. In Nature, 1993
Here we report the isolation of a complementary DNA from rabbit renal medulla that encodes a 397-amino-acid membrane glycoprotein, UT2, with the functional characteristics of the vasopressin-sensitive urea transporter previously described in in vitro-perfused inner medullary collecting ducts.
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