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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Ubiquitin specific peptidase 46

Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP46 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Jun 2009] (from NCBI)
Top mentioned proteins: Ubiquitin, ACID, UBH1, Rdl, CAN
Papers on USP46
Structural Insights into WD-Repeat 48 Activation of Ubiquitin-Specific Protease 46.
Harris et al., San Francisco, United States. In Structure, Dec 2015
The WD-repeat protein WDR48 (USP1-associated factor UAF-1) stimulates activity of ubiquitin-specific proteases USP1, USP12, and USP46.
Identification of candidate genes for familial early-onset essential tremor.
Clark et al., New York City, United States. In Eur J Hum Genet, Nov 2015
HAPLN4 (BRAL2) and USP46.
The deubiquitinating enzyme USP46 regulates AMPA receptor ubiquitination and trafficking.
Man et al., Boston, United States. In J Neurochem, Sep 2015
In this study, we identify USP46 as the deubiquitinating enzyme for AMPARs.
USP46: a new piece of the memory puzzle?
Ferreira et al., Rio de Janeiro, Brazil. In J Neurochem, Sep 2015
This Editorial Highlight discusses the relevance of a study published in the current issue of Journal of Neurochemistry, in which the authors Huo and collaborators now identified ubiquitin-specific peptidase 46 (USP46) as a specific AMPAR deubiquitinase.
Artificial Recruitment of UAF1-USP Complexes by a PHLPP1-E1 Chimeric Helicase Enhances Human Papillomavirus DNA Replication.
Archambault et al., Montréal, Canada. In J Virol, Jun 2015
UNLABELLED: The E1 helicase from anogenital human papillomavirus (HPV) types interacts with the cellular WD repeat-containing protein UAF1 in complex with the deubiquitinating enzyme USP1, USP12, or USP46.
The EBNA3 family of Epstein-Barr virus nuclear proteins associates with the USP46/USP12 deubiquitination complexes to regulate lymphoblastoid cell line growth.
Johannsen et al., Cambridge, United States. In Plos Pathog, Apr 2015
Mass-spectrometry revealed that the EBNA3A and EBNA3B complexes also contained the deubquitylation complex consisting of WDR48, WDR20, and USP46 (or its paralog USP12) and that EBNA3C complexes contained WDR48.
Impaired Maternal Behavior in Usp46 Mutant Mice: A Model for Trans-Generational Transmission of Maternal Care.
Ebihara et al., Nagoya, Japan. In Plos One, 2014
Usp46 mutant mice (congenic strain on a B6 genetic background; MT mice) have a low weaning rate and display poor maternal behavior compared to C57BL/6J mice (B6 mice).
Structure-function analysis of USP1: insights into the role of Ser313 phosphorylation site and the effect of cancer-associated mutations on autocleavage.
Rodríguez et al., Leioa, Spain. In Mol Cancer, 2014
The UAF1 binding site in a second UAF1-interacting DUB, USP46, was mapped to a region homologous to USP1(420-520).
E1-mediated recruitment of a UAF1-USP deubiquitinase complex facilitates human papillomavirus DNA replication.
Archambault et al., Montréal, Canada. In J Virol, 2014
In this study, we determined by affinity purification of UAF1 that it interacts with three deubiquitinating enzymes in C33A cervical carcinoma cells: USP1, a nuclear protein, and the two cytoplasmic enzymes USP12 and USP46.
The WD40-repeat proteins WDR-20 and WDR-48 bind and activate the deubiquitinating enzyme USP-46 to promote the abundance of the glutamate receptor GLR-1 in the ventral nerve cord of Caenorhabditis elegans.
Juo et al., Boston, United States. In J Biol Chem, 2014
The WD40-repeat (WDR) proteins WDR20 and WDR48/UAF1 have been shown to bind to USP46 and stimulate its catalytic activity in other systems.
Downregulation of PHLPP expression contributes to hypoxia-induced resistance to chemotherapy in colon cancer cells.
Gao et al., In Mol Cell Biol, 2013
Moreover, oxygen deprivation destabilizes PHLPP protein by decreasing the expression of USP46, a deubiquitinase of PHLPP.
The deubiquitination enzyme USP46 functions as a tumor suppressor by controlling PHLPP-dependent attenuation of Akt signaling in colon cancer.
Gao et al., Lexington, United States. In Oncogene, 2013
In this study, we show that the deubiquitinase USP46 stabilizes the expression of both PHLPP isoforms by reducing the rate of PHLPP degradation.
Behavioral characteristics of ubiquitin-specific peptidase 46-deficient mice.
Ebihara et al., Nagoya, Japan. In Plos One, 2012
We have previously identified Usp46, which encodes for ubiquitin-specific peptidase 46, as a quantitative trait gene affecting the immobility time of mice in the tail suspension test (TST) and forced swimming test.
Ubiquitin-specific peptidase 46 (Usp46) regulates mouse immobile behavior in the tail suspension test through the GABAergic system.
Ebihara et al., Nagoya, Japan. In Plos One, 2011
We have previously identified ubiquitin-specific peptidase 46 (Usp46) as a quantitative trait gene responsible for decreasing immobility time in the TST in mice.
Possible association between ubiquitin-specific peptidase 46 gene and major depressive disorders in the Japanese population.
Iwata et al., Japan. In J Affect Disord, 2011
results suggest that the USP46 gene might play a role in the pathophysiology of major depressive disorder in the Japanese population.
Lysine 92 amino acid residue of USP46, a gene associated with 'behavioral despair' in mice, influences the deubiquitinating enzyme activity.
Wang et al., Shijiazhuang, China. In Plos One, 2010
results suggest that the Lys 92 deletion of USP46 could influence enzyme activity and thereby provide a molecular clue how the enzyme regulating the pathogenesis of mental illnesses.
Association study of ubiquitin-specific peptidase 46 (USP46) with bipolar disorder and schizophrenia in a Japanese population.
Ozaki et al., Nagoya, Japan. In J Hum Genet, 2010
These data argue against the presence of any strong genetic susceptibility factors for bipolar disorder or schizophrenia in the region USP46.
Usp46 is a quantitative trait gene regulating mouse immobile behavior in the tail suspension and forced swimming tests.
Ebihara et al., Nagoya, Japan. In Nat Genet, 2009
Ubiquitin-specific peptidase 46 (Usp46) with a lysine codon deletion was located in this region.
UAF1 is a subunit of multiple deubiquitinating enzyme complexes.
D'Andrea et al., Boston, United States. In J Biol Chem, 2009
two novel multisubunit deubiquitinating enzyme complexes containing USP12 and USP46, respectively. Both complexes contain the UAF1 protein as a bona fide subunit. Interestingly, UAF1
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