Fine-mapping and candidate gene investigation within the PARK10 locus.
Jacksonville, United States. In Eur J Hum Genet, 2009
After correction for multiple testing, markers within ubiquitin specific peptidase 24 (USP24) are significantly associated with PD within Norwegian, Irish, and US series combined (rs13312: odds ratio (OR) 0.78, P<0.001; rs487230: OR 0.80, P=0.001).
Identification of risk and age-at-onset genes on chromosome 1p in Parkinson disease.
Durham, United States. In Am J Hum Genet, 2005
Using the overall data set of 267 multiplex families, we identified six associated genes in the region, but further screening of a subset of 83 families linked to the chromosome 1 locus identified only two genes significantly associated with AAO in PD: the gamma subunit of the translation initiation factor EIF2B gene (EIF2B3), which was more significant in the linked subset and the ubiquitin-specific protease 24 gene (USP24).