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Ubiquitin specific peptidase 21

USP21, USP23, Ubiquitin Specific Peptidase 21
This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Ubiquitin, Histone, V1a, fibrillin-1, HAD
Papers on USP21
BEND3 represses rDNA transcription by stabilizing a NoRC component via USP21 deubiquitinase.
Prasanth et al., Urbana, United States. In Proc Natl Acad Sci U S A, Aug 2015
BEND3 associates with the nucleolar-remodeling complex (NoRC), and SUMOylated BEND3 stabilizes NoRC component TTF-1-interacting protein 5 via association with ubiquitin specific protease 21 (USP21) debiquitinase.
Ubiquitin specific protease 21 is dispensable for normal development, hematopoiesis and lymphocyte differentiation.
Nijnik et al., Montréal, Canada. In Plos One, 2014
USP21 is a ubiquitin specific protease that catalyzes protein deubiquitination, however the identification of its physiological substrates remains challenging.
Integrative analysis of 1q23.3 copy-number gain in metastatic urothelial carcinoma.
Rosenberg et al., Sabadell, Spain. In Clin Cancer Res, 2014
The F11R, PFDN2, PPOX, USP21, and DEDD genes, all located on 1q23.3, were closely associated with poor outcome.
USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase.
Yang et al., Houston, United States. In J Exp Med, 2014
Here, we report that USP21 acts as a novel negative regulator in antiviral responses through its ability to bind to and deubiquitinate RIG-I.
Deubiquitination and stabilization of IL-33 by USP21.
Li et al., Shanghai, China. In Int J Clin Exp Pathol, 2013
Ubiquitin-specific protease 21 (USP21) interacts with IL-33 and also localizes in nucleus.
Identification of the E3 deubiquitinase ubiquitin-specific peptidase 21 (USP21) as a positive regulator of the transcription factor GATA3.
Li et al., Shanghai, China. In J Biol Chem, 2013
Here, we show how USP21 interacts with and stabilizes GATA3 by mediating its deubiquitination.
The USP21 short variant (USP21SV) lacking NES, located mostly in the nucleus in vivo, activates transcription by deubiquitylating ubH2A in vitro.
Ito et al., Nagasaki, Japan. In Plos One, 2012
USP21 is a deubiquitylase that catalyzes isopeptide bond hydrolysis between ubiquitin and histone H2A.
Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions.
Clague et al., Liverpool, United Kingdom. In Mol Biol Cell, 2012
Study observed a reduction in the number of A549 cells developing a primary cilium upon serum starvation when USP21 was depleted with two independent siRNA oligos.
A global survey of CRM1-dependent nuclear export sequences in the human deubiquitinase family.
Rodríguez et al., Leioa, Spain. In Biochem J, 2012
We tested the effect of the CRM1 inhibitor LMB (leptomycin B) on the localization of YFP (yellow fluorescent protein)- or GFP (green fluorescent protein)-tagged versions of six NES-bearing deubiquitinases [USP (ubiquitin-specific peptidase) 1, USP3, USP7, USP21, CYLD (cylindromatosis) and OTUD7B (OTU-domain-containing 7B)].
Polyubiquitin binding and cross-reactivity in the USP domain deubiquitinase USP21.
Komander et al., Cambridge, United Kingdom. In Embo Rep, 2011
Study report that USP21 cleaves Ub polymers, and with reduced activity also targets ISG15, but is inactive against NEDD8.
Analysing the stability of two oral carbamazepine suspensions.
Selva Otaolaurruchi et al., Alacant, Spain. In Farm Hosp, 2011
RESULTS: The final concentration at 6 months for both the 2.5% and 5% carbamazapine suspensions was 22.9 and 45.9 mg/ml respectively, with calculated richness values between 90 and 110% fulfilling USP23 NF18 requirements.
Hepatocyte nuclear factor (HNF)-4alpha-driven epigenetic silencing of the human PED gene.
Beguinot et al., Napoli, Italy. In Diabetologia, 2010
HNF-4alpha was also shown to target the histone deacetylase complex associated with silencing mediator of retinoic acid and thyroid hormone receptor, both at the PED promoter, and at GRB14 and USP21 regulatory regions, leading to a reduction of mRNA levels.
Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1.
Yang et al., Houston, United States. In J Biol Chem, 2010
USP21 plays an important role in the down-regulation of TNFalpha-induced NF-kappaB activation through deubiquitinating RIP1.
Deubiquitylation of histone H2A activates transcriptional initiation via trans-histone cross-talk with H3K4 di- and trimethylation.
Ito et al., Nagasaki, Japan. In Genes Dev, 2008
The levels of ubH2A vary during hepatocyte regeneration, and based on microarray expression data from regenerating liver, we identified USP21, a ubiquitin-specific protease that catalyzes the hydrolysis of ubH2A.
Drug release modulation from cross-linked calcium alginate microdiscs, 2: swelling, compression, and stability of the hydrodynamically-sensitive calcium alginate matrix and the associated drug release mechanisms.
Hurbans et al., Durban, South Africa. In Drug Deliv, 1997
The influence of dissolution variables/hydrodynamics on drug release behavior was evaluated in accordance with the standard USP23 apparatus I and II, as well as the unofficial rotating bottle method.
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