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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Ubiquitin specific peptidase 11

USP11, UHX1, Ubiquitin Specific Peptidase 11
Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This gene encodes a deubiquitinating enzyme which lies in a gene cluster on chromosome Xp11.23 [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Ubiquitin, CAN, Inactive, USP15, STEP
Papers on USP11
USP11 Is a Negative Regulator to γH2AX Ubiquitylation by RNF8/RNF168.
Zhao et al., Beijing, China. In J Biol Chem, Feb 2016
We identified that USP11 is a unique deubiquitylation enzyme for γH2AX.
A mechanism for the suppression of homologous recombination in G1 cells.
Durocher et al., Toronto, Canada. In Nature, Jan 2016
PALB2 ubiquitylation suppresses its interaction with BRCA1 and is counteracted by the deubiquitylase USP11, which is itself under cell cycle control.
USP11, Deubiquitinating Enzyme, Associated with Neuronal Apoptosis Following Intracerebral Hemorrhage.
Zhang et al., Nantong, China. In J Mol Neurosci, Oct 2015
USP11, located on the X chromosome, 6 is a member of USP subclass of the DUB family.
USP11-dependent selective cIAP2 deubiquitylation and stabilization determine sensitivity to Smac mimetics.
Song et al., Seoul, South Korea. In Cell Death Differ, Sep 2015
Ubiquitin-specific protease 11 (USP11) is a deubiquitylase that directly stabilizes cIAP2.
Ubiquitin-specific Protease 11 (USP11) Deubiquitinates Hybrid Small Ubiquitin-like Modifier (SUMO)-Ubiquitin Chains to Counteract RING Finger Protein 4 (RNF4).
Vertegaal et al., Copenhagen, Denmark. In J Biol Chem, Jul 2015
Using a proteomic approach, we identified the deubiquitinating enzyme ubiquitin-specific protease 11 (USP11), a known DDR-component, as a functional interactor of RNF4.
USP11 regulates p53 stability by deubiquitinating p53.
Wu et al., Quanzhou, China. In J Zhejiang Univ Sci B, 2014
To better understand the regulation of p53, we tested the interaction between p53 and USP11 using co-immunoprecipitation.
Evolution of the highly networked deubiquitinating enzymes USP4, USP15, and USP11.
Gray et al., Ottawa, Canada. In Bmc Evol Biol, 2014
BACKGROUND: USP4, USP15 and USP11 are paralogous deubiquitinating enzymes as evidenced by structural organization and sequence similarity.
Streamlining the Pipeline for Generation of Recombinant Affinity Reagents by Integrating the Affinity Maturation Step.
Kay et al., Chicago, United States. In Int J Mol Sci, 2014
We demonstrate the utility of this approach by generating low nanomolar fibronectin type III (FN3) monobodies to five human proteins: ubiquitin-conjugating enzyme E2 R1 (CDC34), COP9 signalosome complex subunit 5 (COPS5), mitogen-activated protein kinase kinase 5 (MAP2K5), Splicing factor 3A subunit 1 (SF3A1) and ubiquitin carboxyl-terminal hydrolase 11 (USP11).
Structure and catalytic regulatory function of ubiquitin specific protease 11 N-terminal and ubiquitin-like domains.
Dreveny et al., Nottingham, United Kingdom. In Biochemistry, 2014
The ubiquitin specific protease 11 (USP11) is implicated in DNA repair, viral RNA replication, and TGFβ signaling.
Integrative functional genomics of hepatitis C virus infection identifies host dependencies in complete viral replication cycle.
Liang et al., Bethesda, United States. In Plos Pathog, 2014
We also demonstrated that guanine nucleotide binding protein GNB2L1, E2 ubiquitin-conjugating enzyme UBE2J1, and 39 other host factors are required for HCV RNA replication, while the deubiquitinating enzyme USP11 and multiple other cellular genes are specifically involved in HCV IRES-mediated translation.
USP11 regulates PML stability to control Notch-induced malignancy in brain tumours.
Chen et al., Taipei, Taiwan. In Nat Commun, 2013
Here we identify USP11 as a PML regulator by RNAi screening.
Identification of hepatic microvascular adhesion-related genes of human colon cancer cells using random homozygous gene perturbation.
Vidal-Vanaclocha et al., Leioa, Spain. In Int J Cancer, 2013
Some were proadhesive genes detected because of their overexpression in adherent HT-29 cells (DGCR8 and EFEMP1 genes) and their silenced status in nonadherent HT-29 cells (DGKE, DPY19L1, KIAA0753, PVR and USP11 genes).
Mitoxantrone targets human ubiquitin-specific peptidase 11 (USP11) and is a potent inhibitor of pancreatic cancer cell survival.
Brody et al., Philadelphia, United States. In Mol Cancer Res, 2013
Ubiquitin-specific peptidase 11 (USP11), an enzyme that interacts with the DDR protein BRCA2, was recently discovered to play a key role in DNA double-strand break repair and may be a novel therapeutic target.
USP11 augments TGFβ signalling by deubiquitylating ALK5.
Sapkota et al., Dundee, United Kingdom. In Open Biol, 2012
In this report, we identify a deubiquitylating enzyme USP11 as an interactor of SMAD7.
Structure of the USP15 N-terminal domains: a β-hairpin mediates close association between the DUSP and UBL domains.
Dreveny et al., Nottingham, United Kingdom. In Biochemistry, 2011
USP15 forms a subfamily with USP4 and USP11 related through a shared presence of N-terminal "domain present in ubiquitin specific proteases" (DUSP) and "ubiquitin-like" (UBL) domains (DU subfamily).
Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor.
Peters et al., London, United Kingdom. In Embo J, 2010
Ablation of either USP7 or USP11 in primary human fibroblasts results in de-repression of the INK4a tumour suppressor accompanied by loss of Polycomb repressive complex 1 binding at the locus and a senescence-like proliferative arrest.
USP11 negatively regulates TNFalpha-induced NF-kappaB activation by targeting on IkappaBalpha.
Yang et al., Houston, United States. In Cell Signal, 2010
Ubiquitin specific protease 11 protein plays an important role in maintaining a delicate balance in TNFalpha-mediated inflammatory responses by being a part of Yin-Yang regulatory mechanism.
USP11 stabilizes HPV-16E7 and further modulates the E7 biological activity.
Yu et al., Taiwan. In J Biol Chem, 2008
USP11 plays an important role in regulating the levels of E7 protein and subsequently affects the biological function of E7 as well as its contribution to cell transformation by HPV-16E7.
The deubiquitinating enzyme USP11 controls an IkappaB kinase alpha (IKKalpha)-p53 signaling pathway in response to tumor necrosis factor alpha (TNFalpha).
Yoshida et al., Tokyo, Japan. In J Biol Chem, 2007
the ectopic expression of IKKalpha into cells silenced for USP11 restores p53 expression, demonstrating that USP11 functions as an upstream regulator of an IKKalpha-p53 signaling pathway.
BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damage.
Aaronson et al., New York City, United States. In Mol Cell Biol, 2004
Results suggest that BRCA2 expression levels are regulated by ubiquitination in response to DNA damage and that USP11 participates in DNA damage repair functions within the BRCA2 pathway independently of BRCA2 deubiquitination.
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