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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Upstream transcription factor 2, c-fos interacting

USF2, upstream stimulatory factor 2
This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: USF, CAN, c-Myc, V1a, ACID
Papers on USF2
The nuclear fraction of protein kinase CK2 binds to the upstream stimulatory factors (USFs) in the absence of DNA.
Götz et al., Homburg, Germany. In Cell Signal, Feb 2016
The functions of the upstream stimulatory factors USF1 and USF2 are, like those of other transcription factors, regulated by reversible phosphorylation.
Genome-wide analyses in neuronal cells reveal that USF transcription factors regulate lysosomal gene expression.
Nukina et al., Kyoto, Japan. In Febs J, Feb 2016
UNASSIGNED: The upstream stimulating factors (USFs) USF1 and USF2 are ubiquitously expressed transcription factors characterized by a conserved basic helix-loop-helix leucine zipper DNA-binding domain.
The expression profile analysis of NKX2-5 knock-out embryonic mice to explore the pathogenesis of congenital heart disease.
Huang et al., Shanghai, China. In J Cardiol, Dec 2015
The transcriptional regulatory networks included five down-regulated DEGs (SP1, SRY, JUND, STAT6, and GATA6), and six up-regulated DEGs [POU2F1, NFY (NFYA/NFYB/NFYC), USF2 and MAX].
Method for trapping affinity chromatography of transcription factors using aldehyde-hydrazide coupling to agarose.
Jarrett et al., San Antonio, United States. In Anal Biochem, Sep 2015
Using a different oligonucleotide with the proximal E-box sequence from the human telomerase promoter, USF-2 transcription factor was purified by trapping, again with higher purity than results from conventional affinity chromatography and similar yield.
Vascular smooth muscle LRP6 limits arteriosclerotic calcification in diabetic LDLR-/- mice by restraining noncanonical Wnt signals.
Towler et al., Grand Rapids, United States. In Circ Res, Aug 2015
RNA interference revealed that USF1 but not USF2 supports OPN expression in LRP6-VKO vascular smooth muscle lineage, and immunoprecipitation confirmed increased USF1 association with OPN chromatin.
Gene expression changes in human mesenchymal stem cells from patients with osteoporosis.
Gu et al., Shanghai, China. In Mol Med Report, Jul 2015
The nine genes with a high (≥ 9) degree in the constructed transcriptional regulatory network were REL-associated protein, upstream stimulatory factor 1, specificity protein 1, Fos-related antigen 1, cyclin-dependent kinase inhibitor 1A, upstream stimulatory factor 2, ETS domain-containing protein Elk1, JUND and retinoic acid receptor α, with degrees of 29, 27, 19, 18, 17, 13, 11, 11 and 9, respectively.
Role of upstream stimulatory factor 2 in diabetic nephropathy.
Wang, Lexington, United States. In Front Biol, Jun 2015
Studies from our laboratory demonstrated that the transcription factor-upstream stimulatory factor 2 (USF2) is an important regulator of DN.
Protein kinases as switches for the function of upstream stimulatory factors: implications for tissue injury and cancer.
Dimova et al., Oulu, Finland. In Front Pharmacol, 2014
Both USF1 and USF2 are supposed to have major roles in metabolism, tissue protection and tumor development.
The ATP-Binding Cassette Transporter-2 (ABCA2) Overexpression Modulates Sphingosine Levels and Transcription of the Amyloid Precursor Protein (APP) Gene.
Davis, Charleston, United States. In Curr Alzheimer Res, 2014
Activation of the human APP promoter in A2 cells was directed by the upstream stimulatory factors USF-1 and USF-2 that bound to an E-box element in vivo.
Differential expression of upstream stimulatory factor (USF) 2 variants in eutopic endometria from women with endometriosis: estradiol regulation.
Johnson et al., Santiago, Chile. In Biol Res, 2014
In isolated control epithelial cells incubated with E2 and PGE2, to resemble the endometriosis condition, the data showed: (a) significant increase of USF2a and USF2b nuclear protein contents when treated with E2, PPT (specific agonist for ERα) or G1 (specific agonist for GPER1); (b) no increase in USF2 binding to SF-1 E-Box/DNA consensus sequence in E2-treated cells; (c) USF2 variants protein contents were not modified by PGE2; (d) SF-1 nuclear protein content was significantly higher than basal when treated with PGE2, E2 or G1, stimulation unaffected by ICI (nuclear ER antagonist); and (e) increased (p < 0.05) cytosolic protein contents of P450Arom when treated with PGE2, E2, PPT or G1 compared to basal, effect that was additive with E2 + PGE2 together.
Insulin signalling mechanisms for triacylglycerol storage.
Aouadi et al., Worcester, United States. In Diabetologia, 2013
New findings include (1) activation of DNA-dependent protein kinase to stimulate upstream stimulatory factor (USF)1/USF2 heterodimers, enhancing the lipogenic transcription factor sterol regulatory element binding protein 1c (SREBP1c); (2) stimulation of fatty acid synthase through AMP kinase modulation; (3) mobilisation of lipid droplet proteins to promote retention of triacylglycerol; and (4) upregulation of a novel carbohydrate response element binding protein β isoform that potently stimulates transcription of lipogenic enzymes.
Chromatin domains, insulators, and the regulation of gene expression.
Felsenfeld et al., Bethesda, United States. In Biochim Biophys Acta, 2012
Barrier insulation is mediated by two kinds of DNA binding proteins: USF1/USF2, a heterodimer which recruits multiple enzyme complexes capable of marking histone on adjacent nucleosomes with 'activating' marks, and Vezf1, which protects against DNA methylation.
Gene trapping uncovers sex-specific mechanisms for upstream stimulatory factors 1 and 2 in angiotensinogen expression.
Sigmund et al., Iowa City, United States. In Hypertension, 2012
Data suggest that both USF1 and USF2 are essential for angiotensinogen (AGT) transcriptional regulation, and distinct sex-specific and tissue-specific mechanisms are involved in the activities of these transcription factors.
DNA double-strand breaks relieve USF-mediated repression of Dβ2 germline transcription in developing thymocytes.
Sikes et al., Raleigh, United States. In J Immunol, 2012
USF-1 but not USF-2 was strongly enriched at Dbeta2 in chromatin from either Rag2-/- double-negative thymocytes or Rag2-/- thymocytes that express a rearranged Tcrb transgene.
TGF-β1 → SMAD/p53/USF2 → PAI-1 transcriptional axis in ureteral obstruction-induced renal fibrosis.
Higgins et al., Albany, United States. In Cell Tissue Res, 2012
Chronic kidney disease constitutes an increasing medical burden affecting 26 million people in the United States alone.
ID1 inhibits USF2 and blocks TGF-β-induced apoptosis in mesangial cells.
Campos et al., São Paulo, Brazil. In Am J Physiol Renal Physiol, 2011
Bone morphogenetic proteins and ID1 exerted an anti-apoptotic effect in mesangial cells by inhibition of USF2 transcriptional activity.
Upstream stimulatory factor induces Nr5a1 and Shbg gene expression during the onset of rat Sertoli cell differentiation.
Walker et al., Pittsburgh, United States. In Biol Reprod, 2011
Upstream stimulatory factors (USF1 and USF2) induce Nr5a1 and Shbg gene expression during the onset of rat Sertoli cell differentiation.
Identification and functional analysis of a second RBF-2 binding site within the HIV-1 promoter.
Sadowski et al., Vancouver, Canada. In Virology, 2011
These data indicate that an E-box motif (RBE1) within the core promoter in the long terminal repeat of HIV-1 is a bona fide binding site for the RBF-2 transcription factor complex USF1, USF2, and TFII-I.
Role of helix-loop-helix proteins during differentiation of erythroid cells.
Bungert et al., Gainesville, United States. In Mol Cell Biol, 2011
Among the HLH proteins expressed in differentiating erythroid cells are the ubiquitous proteins Myc, USF1, USF2, and TFII-I, as well as the hematopoiesis-specific transcription factor Tal1/SCL.
[HINT1--a novel tumor suppressor protein of the HIT superfamily].
Ozga, Łódź, Poland. In Postepy Biochem, 2009
Recent findings have shown that Hint1 inhibits the activity of the transcription factors AP1, MITF and USF2, as well as influences the transcription process of some genes of Wnt/beta-catenin pathway.
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