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Upstream transcription factor 1

USF, USF1, upstream stimulatory factor
This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. This gene has been linked to familial combined hyperlipidemia (FCHL). Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: USF2, CAN, SP1, CIs, c-Myc
Papers using USF antibodies
A single lentiviral vector platform for microRNA-based conditional RNA interference and coordinated transgene expression.
Lee Jeannie T., In PLoS Genetics, 2005
... Antibodies against ubiquitin (sc-8017), (BML-PW8805) and USF1 (H00007391-A01) were obtained from Santa Cruz, Enzo Life Sciences and Abnova, respectively ...
Topological Requirements and Signaling Properties of T Cell–activating, Anti-CD28 Antibody Superagonists
Hünig Thomas et al., In The Journal of Experimental Medicine, 1995
... anti–human TCRζ (clone 6B10.2) and rabbit polyclonal antibodies to nuclear factor (NF)-κB p50, c-rel, and USF-2 were from Santa Cruz Biotechnology, Inc., and mouse anti–human ...
Papers on USF
The nuclear fraction of protein kinase CK2 binds to the upstream stimulatory factors (USFs) in the absence of DNA.
Götz et al., Homburg, Germany. In Cell Signal, Feb 2016
The functions of the upstream stimulatory factors USF1 and USF2 are, like those of other transcription factors, regulated by reversible phosphorylation.
Genome-wide analyses in neuronal cells reveal that USF transcription factors regulate lysosomal gene expression.
Nukina et al., Kyoto, Japan. In Febs J, Feb 2016
UNASSIGNED: The upstream stimulating factors (USFs) USF1 and USF2 are ubiquitously expressed transcription factors characterized by a conserved basic helix-loop-helix leucine zipper DNA-binding domain.
Basal transcription of APOBEC3G is regulated by USF1 gene in hepatocyte.
Kang et al., Zhengzhou, China. In Biochem Biophys Res Commun, Feb 2016
To gain new insights into the transcriptional regulation of this restriction factor, we cloned and characterized the promoter region of A3G and investigate the modulation of USF1 gene on the transcription of A3G.
Effects of diabetes drugs on the skeleton.
Lecka-Czernik et al., Basel, Switzerland. In Bone, Jan 2016
In contrast, metformin has a positive effect on osteoblast differentiation due to increased activity of Runx2 via the AMPK/USF-1/SHP regulatory cascade resulting in a neutral or potentially protective effect on bone.
Developmental Stage-Specific Embryonic Induction of HepG2 Cell Differentiation.
Wang et al., Shijiazhuang, China. In Dig Dis Sci, Jan 2016
The nuclear factors controlling differentiation, hepatocyte nuclear factor (HNF)-4α, HNF-1α, HNF-6 and upstream stimulatory factor-1 (USF-1), and the oncogene Myc and alpha-fetoprotein (AFP) were measured.
Positive and negative regulators of the metallothionein gene (review).
Takahashi, Sagamihara, Japan. In Mol Med Report, Jul 2015
Several positive regulators of MT genes, including metal-responsive element-binding transcription factor (MTF)-1 and upstream stimulatory factor (USF)-1, have been identified and mechanisms of induction have been well described.
Bioinformatics Analysis of the Effects of Tobacco Smoke on Gene Expression.
Zou et al., Shanghai, China. In Plos One, 2014
In the transcriptional regulatory network, transcription factors of MYC associated factor X (MAX) and upstream transcription factor 1 (USF1) regulated many overlapped DEGs.
Familial combined hyperlipidemia: from molecular insights to tailored therapy.
Brouwers et al., Nijmegen, Netherlands. In Curr Opin Lipidol, 2014
Finally, gene expression studies in liver biopsies and liver cell culture experiments have gained further insight in the role of upstream stimulatory factor 1, one of the most replicated genes in FCHL, in its pathogenesis.On the basis of these observations and recent phase II clinical trials, PCSK9 antagonizing is the most promising lipid-lowering therapy to be added to our current arsenal of statins and fibrates in FCHL treatment.
The transcription factor DREAM represses the deubiquitinase A20 and mediates inflammation.
Malik et al., Chicago, United States. In Nat Immunol, 2014
In contrast, binding of the transcription factor USF1 to the DRE-associated E-box domain in the gene encoding A20 activated its expression in response to inflammatory stimuli.
Insulin signalling mechanisms for triacylglycerol storage.
Aouadi et al., Worcester, United States. In Diabetologia, 2013
New findings include (1) activation of DNA-dependent protein kinase to stimulate upstream stimulatory factor (USF)1/USF2 heterodimers, enhancing the lipogenic transcription factor sterol regulatory element binding protein 1c (SREBP1c); (2) stimulation of fatty acid synthase through AMP kinase modulation; (3) mobilisation of lipid droplet proteins to promote retention of triacylglycerol; and (4) upregulation of a novel carbohydrate response element binding protein β isoform that potently stimulates transcription of lipogenic enzymes.
Upstream stimulatory factor 1 activates GATA5 expression through an E-box motif.
Solway et al., Chicago, United States. In Biochem J, 2012
USF1 transactivates GATA5 expression by binding to the E-box in its promoter
Potential role of upstream stimulatory factor 1 gene variant in familial combined hyperlipidemia and related disorders.
Patsch et al., Salzburg, Austria. In Arterioscler Thromb Vasc Biol, 2012
Identify transcriptional circuitry whereby USF-1 variants influence hepatic triglyceride secretion in familial combined hyperlipidemia and related disorders.
Gene trapping uncovers sex-specific mechanisms for upstream stimulatory factors 1 and 2 in angiotensinogen expression.
Sigmund et al., Iowa City, United States. In Hypertension, 2012
Data suggest that both USF1 and USF2 are essential for angiotensinogen (AGT) transcriptional regulation, and distinct sex-specific and tissue-specific mechanisms are involved in the activities of these transcription factors.
DNA double-strand breaks relieve USF-mediated repression of Dβ2 germline transcription in developing thymocytes.
Sikes et al., Raleigh, United States. In J Immunol, 2012
USF-1 binds the 5'PDbeta2 repressor element (E-box) in developing double-negative thymocytes.
Chromatin insulator elements: establishing barriers to set heterochromatin boundaries.
West et al., Glasgow, United Kingdom. In Epigenomics, 2012
We look at the mechanisms vertebrate barrier proteins, such as USF1 and VEZF1, employ to counteract Polycomb- and heterochromatin-associated repression.
USF-1 is critical for maintaining genome integrity in response to UV-induced DNA photolesions.
Galibert et al., Rennes, France. In Plos Genet, 2012
using a mouse model we show that the loss of USF-1 compromises DNA repair, which suggests that USF-1 plays an important role in maintaining genomic stability.
A role of DNA-PK for the metabolic gene regulation in response to insulin.
Sul et al., Berkeley, United States. In Cell, 2009
Under fasting conditions, USF-1 is deacetylated by HDAC9, causing promoter inactivation.
Familial combined hyperlipidemia is associated with upstream transcription factor 1 (USF1).
Peltonen et al., Los Angeles, United States. In Nat Genet, 2004
familial combined hyperlipidemia was linked and associated with the USF1 gene in 60 extended Finnish families
Transposable B2 SINE elements can provide mobile RNA polymerase II promoters.
Aberdam et al., Nice, France. In Nat Genet, 2001
The B2 pol II promoters can be bound and stimulated by the transcription factor USF (for upstream stimulatory factor), as shown by transient transfection experiments.
Activation of the MHC class II transactivator CIITA by interferon-gamma requires cooperative interaction between Stat1 and USF-1.
Mach et al., Genève, Switzerland. In Immunity, 1998
Stat1 binds to the GAS site only in the presence of the ubiquitous factor USF-1, which binds to the adjacent E box.
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