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USE1 Use1p

USE1, Use1p, UBE2Z, SNARE-like tail-anchored protein 1
This gene encodes an enzyme which ubiquitinates proteins which participate in signaling pathways and apoptosis. [provided by RefSeq, Feb 2012] (from NCBI)
Top mentioned proteins: Ubiquitin, Uba6, CIs, CAN, fibrillin-1
Papers on USE1
Structure of UBE2Z Enzyme Provides Functional Insight into Specificity in the FAT10 Protein Conjugation Machinery.
Rucktooa et al., Amsterdam, Netherlands. In J Biol Chem, Feb 2016
FAT10 conjugation, a post-translational modification analogous to ubiquitination, specifically requires UBA6 and UBE2Z as its activating (E1) and conjugating (E2) enzymes.
Association of genetic variants with dyslipidemia.
Yamada et al., Gifu, Japan. In Mol Med Report, Oct 2015
rs46522 of ubiquitin‑conjugating enzyme E2Z gene (UBE2Z; FDR=0.032) and rs17514846 of furin (FDR=0.041)
Association of a polymorphism of the interleukin 6 receptor gene with chronic kidney disease in Japanese individuals.
Yamada et al., Tajimi, Japan. In Nephrology (carlton), Apr 2015
RESULTS: The χ(2) test revealed that rs4845625 (T→C) of IL6R, rs4773144 (A→G) of COL4A1, rs9319428 (G→A) of FLT1, and rs46522 (T→C) of UBE2Z were significantly (P < 0.05) related to CKD.
Profiling of ubiquitination pathway genes in peripheral cells from patients with frontotemporal dementia due to C9ORF72 and GRN mutations.
Galimberti et al., Milano, Italy. In Int J Mol Sci, 2014
In GRN mutation carriers, no statistically significant deregulation of ubiquitination pathway genes was observed, except for the UBE2Z gene, which displays E2 ubiquitin conjugating enzyme activity, and was found to be statistically significant up-regulated (p = 0.006).
TANGO1 recruits ERGIC membranes to the endoplasmic reticulum for procollagen export.
Malhotra et al., Barcelona, Spain. In Elife, 2014
Along with the t-SNARE Syntaxin 18, we now reveal the complete complement of SNAREs required in this process, t-SNAREs BNIP1 and USE1, and v-SNARE YKT6.
Conjugation of the ubiquitin activating enzyme UBE1 with the ubiquitin-like modifier FAT10 targets it for proteasomal degradation.
Aichem et al., Kreuzlingen, Switzerland. In Plos One, 2014
The conjugation machinery consists of the bispecific E1 activating enzyme Ubiquitin-like modifier activating enzyme 6 (UBA6), the likewise bispecific E2 conjugating enzyme UBA6-specific E2 enzyme 1 (USE1), and possibly E3 ligases.
Evaluating the association of common UBE2Z variants with coronary artery disease in an Iranian population.
Masotti et al., Tehrān, Iran. In Cell Mol Biol (noisy-le-grand), 2014
Notably, a recent study has identified UBE2Z rs46522 at 17q21.32 as a CAD-susceptibility variant in Europeans.
Ufmylation and FATylation pathways are downregulated in human alcoholic and nonalcoholic steatohepatitis, and mice fed DDC, where Mallory-Denk bodies (MDBs) form.
French et al., Torrance, United States. In Exp Mol Pathol, 2014
The FAT10-specific E1 and E2 enzymes Uba6 and USE1, however, were found to be downregulated both in patients' livers and in the liver of DDC re-fed mice.
Investigations into the auto-FAT10ylation of the bispecific E2 conjugating enzyme UBA6-specific E2 enzyme 1.
Groettrup et al., Kreuzlingen, Switzerland. In Febs J, 2014
FAT10 is conjugated to its substrates via the bispecific, ubiquitin-activating and FAT10-activating enzyme UBA6, the likewise bispecific conjugating enzyme UBA6-specific E2 enzyme 1 (USE1), and possibly E3 ligases.
Two novel type 2 diabetes loci revealed through integration of TCF7L2 DNA occupancy and SNP association data.
Grant et al., Philadelphia, United States. In Bmj Open Diabetes Res Care, 2013
When investigating all the known GWAS loci bound by TCF7L2 in the shortest gene list, derived from HCT116, the coronary artery disease-associated variant, rs46522 at the UBE2Z-GIP-ATP5G1-SNF8 locus, yielded significant association with T2D within DIAGRAM.
Associations between the CDKN2A/B, ADTRP and PDGFD polymorphisms and the development of coronary atherosclerosis in Japanese patients.
Muramatsu et al., Tokyo, Japan. In J Atheroscler Thromb, 2013
The present study attempted to replicate the results for eight of these loci, CDKN2A/B(rs1333049), ADTRP(rs6903956), PDGFD(rs974819), TCF21(rs12190287), COL4A1-A2(rs4773144), HHIPL1(rs2895811), ADAMTS7(rs4380028) and UBE2Z(rs46522), in patients with pathologically defined atherosclerosis of the coronary arteries.
ER-associated SNAREs and Sey1p mediate nuclear fusion at two distinct steps during yeast mating.
Rose et al., Princeton, United States. In Mol Biol Cell, 2013
Here we demonstrate that the ER-localized SNAREs Sec20p, Ufe1p, Use1p, and Bos1p are required for efficient nuclear fusion.
Translation- and SRP-independent mRNA targeting to the endoplasmic reticulum in the yeast Saccharomyces cerevisiae.
Gerst et al., Israel. In Mol Biol Cell, 2013
To better understand mSMP targeting, we examined aptamer-tagged USE1, which encodes a tail-anchored membrane protein, and SUC2, which encodes a soluble secreted enzyme.
The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation.
Groettrup et al., Kreuzlingen, Switzerland. In J Cell Sci, 2012
Nevertheless, only three substrates have been identified so far to which FAT10 becomes covalently attached through a non-reducible isopeptide bond, and these are the FAT10-conjugating enzyme USE1 which auto-FAT10ylates itself in cis, the tumor suppressor p53 and the ubiquitin-activating enzyme UBE1 (UBA1).
ER Import Sites and Their Relationship to ER Exit Sites: A New Model for Bidirectional ER-Golgi Transport in Higher Plants.
Robinson et al., Heidelberg, Germany. In Front Plant Sci, 2011
We screened several SNAREs (SYP81, the SYP7 family, and USE1) to find a SNARE whose overexpression did not disrupt ER-Golgi traffic and which gave rise to discrete fluorescent punctae when expressed with an XFP tag.
Cloning and characterization of a gene encoding the human putative ubiquitin conjugating enzyme E2Z (UBE2Z).
Mao et al., Shanghai, China. In Mol Biol Rep, 2007
UBE2Z was widely expressed in human tissues and is located on chromosome 17q21.
Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging.
Harper et al., Boston, United States. In Nature, 2007
In tissue culture cells, Uba6 is required for charging a previously uncharacterized Uba6-specific E2 (Use1), whereas Ube1 is required for charging the cell-cycle E2s Cdc34A and Cdc34B
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