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Peptidylprolyl isomerase H

USA-CyP, SnuCyp-20, CypH, cyclophilin H, hUSA-CyP
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Cyp, CAN, CIs, PRP4, V1a
Papers on USA-CyP
Macrophage-mediated renal injury is dependent on signaling via the JNK pathway.
Nikolic-Paterson et al., Australia. In J Am Soc Nephrol, 2004
An adoptive transfer model was used in which rats were immunized with sheep IgG (day -5), made leukopenic by administration of cyclophosphamide (CyPh) (day -2), and then injected with sheep anti-glomerular basement membrane (GBM) serum (day 0).
Two protein-protein interaction sites on the spliceosome-associated human cyclophilin CypH.
Achsel et al., Göttingen, Germany. In Nucleic Acids Res, 2003
Cyclophilins are a family of proteins that share a common, highly conserved sequence motif.
Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide.
Ficner et al., Göttingen, Germany. In J Mol Biol, 2003
Free and complexed cyclophilin H have virtually identical conformations suggesting that the U4/U6-60K binding site is pre-shaped and the peptidyl-prolyl-cis/trans isomerase activity is unaffected by complex formation
Interferon-gamma augments acute macrophage-mediated renal injury via a glucocorticoid-sensitive mechanism.
Nikolic-Paterson et al., Australia. In J Am Soc Nephrol, 2003
In this model, rats were made leukopenic by administration of cyclophosphamide (CyPh).
Identification and characterisation of Schizosaccharomyces pombe cyclophilin 3, a cyclosporin A insensitive orthologue of human USA-CyP.
Kay et al., Brighton, United Kingdom. In J Chromatogr B Analyt Technol Biomed Life Sci, 2003
Cyclophilin 3 is an orthologue of hUSA-CyP, which is associated with Prp4/Prp3 in the [U4/U6.U5] snRNP complex and Prp18, both of which are components of the pre-mRNA splicing machinery.
Adoptive transfer studies demonstrate that macrophages can induce proteinuria and mesangial cell proliferation.
Nikolic-Paterson et al., Australia. In Kidney Int, 2003
METHODS: Accelerated anti-glomerular basement membrane (anti-GBM) disease was induced in rats by immunization with sheep IgG (day -5), followed by administration of sheep anti-rat GBM serum (day 0), with animals killed on day 2. To facilitate the adoptive transfer studies, immunized animals were made leukopenic by cyclophosphamide (CyPh) given on day -2.
A cyclophilin functions in pre-mRNA splicing.
Misteli et al., Bethesda, United States. In Embo J, 2002
We report that the cyclophilin USA-CyP is part of distinct complexes with two spliceosomal proteins and is involved in both steps of pre-mRNA splicing.
A high-resolution integrated map spanning the SDHD gene at 11q23: a 1.1-Mb BAC contig, a partial transcript map and 15 new repeat polymorphisms in a tumour-suppressor region.
Devlin et al., Pittsburgh, United States. In Eur J Hum Genet, 2001
We also discover a processed pseudogene for USA-CYP, a cyclophilin associated with U4/U6 snRPNs, and a novel gene, DDP2, encoding a mitochondrial protein similar to the X-linked deafness-dystonia protein, which is juxtaposed 5'-to-5' to SDHD.
Crystal structure of the human U4/U6 small nuclear ribonucleoprotein particle-specific SnuCyp-20, a nuclear cyclophilin.
Ficner et al., Marburg an der Lahn, Germany. In J Biol Chem, 2000
The cyclophilin SnuCyp-20 is a specific component of the human U4/U6 small nuclear ribonucleoprotein particle involved in the nuclear splicing of pre-mRNA.
The 20kD protein of human [U4/U6.U5] tri-snRNPs is a novel cyclophilin that forms a complex with the U4/U6-specific 60kD and 90kD proteins.
Lührmann et al., Marburg an der Lahn, Germany. In Rna, 1998
We have characterized the 20kD protein of the spliceosomal 25S [U4/U6.U5] tri-snRNP complex from HeLa cells and show that it is a novel human cyclophilin (denoted SnuCyp-20).
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