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Urotensin 2 domain containing

URP, urotensin II-related peptide, U2B, U2AF1-RS2
binds urotensin II and produces hypotension [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: urotensin-II, CAN, ACID, HAD, somatostatin
Papers on URP
Time course of organic anion transporter 5 (Oat5) urinary excretion in rats treated with cisplatin: a novel urinary biomarker for early detection of drug-induced nephrotoxicity.
Torres et al., Rosario, Argentina. In Arch Toxicol, Aug 2015
The aim of this study was to evaluate the time course of Oat5 urinary excretion and changes in conventional biomarkers, such as creatinine and urea plasma levels (Urp and Crp), and protein and glucose urinary levels (Pu and Gluu), between others, and compared them to the onset and progression of histological changes after cisplatin treatment.
De Novo Conception of Small Molecule Modulators Based on Endogenous Peptide Ligands: Pyrrolodiazepin-2-one γ-Turn Mimics That Differentially Modulate Urotensin II Receptor-Mediated Vasoconstriction ex Vivo.
Lubell et al., Montréal, Canada. In J Med Chem, Jul 2015
Solid-phase synthesis provided 13 analogues, which were tested for their ability to modulate selectively and differentially the potency (EC50) and efficacy (E(max)) of hUII and URP ex vivo in a rat aortic ring bioassay.
An investigation into the origin of the biased agonism associated with the urotensin II receptor activation.
Carotenuto et al., Napoli, Italy. In J Pept Sci, May 2015
Two endogenous ligands activate UTR, i.e. urotensin II (U-II) and urotensin II-related peptide (URP).
Intra-ventral tegmental area microinjections of urotensin II modulate the effects of cocaine.
Clark et al., Buffalo, United States. In Behav Brain Res, Mar 2015
Furthermore, the second endogenous ligand for the UIIR, urotensin II-related peptide, had the same effect at the 10 pmole dose.
Genetic diversity among monoconidial and polyconidial isolates of Bipolaris sorokiniana.
Van Der Sand et al., Porto Alegre, Brazil. In Curr Microbiol, 2014
In this study, 19 polysporic and 57 monosporic isolates of B. sorokiniana were characterized using universal rice primers-URP-PCR.
Divergent cardio-ventilatory and locomotor effects of centrally and peripherally administered urotensin II and urotensin II-related peptides in trout.
Le Mével et al., Brest, France. In Front Neurosci, 2014
The urotensin II (UII) gene family consists of four paralogous genes called UII, UII-related peptide (URP), URP1 and URP2.
International Union of Basic and Clinical Pharmacology. XCII. Urotensin II, urotensin II-related peptide, and their receptor: from structure to function.
Vaudry et al., Québec, Canada. In Pharmacol Rev, 2014
Phylogenetic studies and synteny analysis indicate that UII and its paralogous peptide urotensin II-related peptide (URP) belong to the somatostatin/cortistatin superfamily.
Generation of BAC transgenic tadpoles enabling live imaging of motoneurons by using the urotensin II-related peptide (ust2b) gene as a driver.
Tostivint et al., Paris, France. In Plos One, 2014
In mammals, the urotensin II-related peptide (UTS2B) gene is primarily expressed in motoneurons of the brainstem and the spinal cord.
Biased signaling regulates the pleiotropic effects of the urotensin II receptor to modulate its cellular behaviors.
Prézeau et al., Sherbrooke, Canada. In Faseb J, 2014
The tested peptides induced three different profiles: UII, urotensin-related peptide (URP), and UII4-11 displayed the full profile; [Orn(8)]UII and [Orn(5)]URP activated G proteins, although with pEC50s 5-10× higher, and did not or barely recruited β-arrestin; urantide also failed to recruit β-arrestin but displayed a reversed rank order for Gi and Gq vs. Go pEC50s (-8.79±0.20,
Comparative distribution and in vitro activities of the urotensin II-related peptides URP1 and URP2 in zebrafish: evidence for their colocalization in spinal cerebrospinal fluid-contacting neurons.
Tostivint et al., Paris, France. In Plos One, 2014
Subsequent studies have demonstrated the occurrence of several UII-related peptides (URPs), such that the UII family is now known to include four paralogue genes called UII, URP, URP1 and URP2.
Splicing factor mutations and cancer.
Ogawa et al., Kyoto, Japan. In Wiley Interdiscip Rev Rna, 2014
These mutations were heterozygous and mainly affected U2AF1 (U2AF35), SRSF2 (SC35), SF3B1 (SF3B155 or SAP155), and ZRSR2 (URP), which are engaged in the initial steps of RNA splicing, including 3' splice-site recognition, and occur in a large mutually exclusive pattern, suggesting a common impact of these mutations on RNA splicing.
Molecular evolution of GPCRs: Somatostatin/urotensin II receptors.
Larhammar et al., Uppsala, Sweden. In J Mol Endocrinol, 2014
Following the 2R event, the vertebrate ancestor is deduced to have possessed three SS (SS1, SS2, and SS5) and six SSTR (SSTR1-6) genes, on the one hand, and four UII (UII, URP, URP1, and URP2) and five UTS2R (UTS2R1-5) genes, on the other hand.
Impact of gene/genome duplications on the evolution of the urotensin II and somatostatin families.
Lihrmann et al., Paris, France. In Gen Comp Endocrinol, 2013
The UII family consists of four paralogous genes called UII, URP, URP1 and URP2 and the SS family is composed of six paralogous genes named SS1, SS2, SS3, SS4, SS5 and SS6.
Biochemical and pharmacological characterization of nuclear urotensin-II binding sites in rat heart.
Chatenet et al., Québec, Canada. In Br J Pharmacol, 2012
U-II and URP can differentially modulate nuclear UT functions such as gene expression, and both ligands can reach the internal cellular space through a receptor-independent mechanism
Frequency and prognostic impact of mutations in SRSF2, U2AF1, and ZRSR2 in patients with myelodysplastic syndromes.
Heuser et al., Hannover, Germany. In Blood, 2012
In univariate analysis, mutated SRSF2 predicted shorter overall survival and more frequent acute myeloid leukemia progression compared with wild-type SRSF2, whereas mutated U2AF1, ZRSR2 had no impact on patient outcome.
Human U2B″ protein binding to snRNA stemloops.
Hall et al., Saint Louis, United States. In Biophys Chem, 2011
U2B'' has a relaxed specificity for its RNA targets.
Direct evidence for the co-expression of URP and GnRH in a sub-population of rat hypothalamic neurones: anatomical and functional correlation.
Grange-Messent et al., Paris, France. In Plos One, 2010
remarkable cellular and subcellular distribution led us to test the effect of URP on the GnRH-induced gonadotrophins release in the anterior pituitary, and to discuss its putative role at the level of the median eminence
The U2AF35-related protein Urp contacts the 3' splice site to promote U12-type intron splicing and the second step of U2-type intron splicing.
Green et al., Kwangju, South Korea. In Genes Dev, 2010
Data show that through recognition of a common splicing element, Urp facilitates distinct steps of U2- and U12-type intron splicing.
Urotensin II, from fish to human.
Leprince et al., Mont-Saint-Aignan, France. In Ann N Y Acad Sci, 2010
A UII paralog called urotensin II-related peptide (URP) has been identified in the rat brain.
A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA.
Fu et al., San Diego, United States. In Nature, 1997
Here we describe the function of a U2AF35-related protein (Urp), which is the human homologue of a mouse imprinted gene.
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