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Urotensin 2

urotensin-II, UII
This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, GPR14, CAN, endothelin-1, V1a
Papers on urotensin-II
COPD: Do Imaging Measurements of Emphysema and Airway Disease Explain Symptoms and Exercise Capacity?
Parraga et al., London, Canada. In Radiology, Dec 2015
Results Multivariate modeling for the 6MWD in 80 patients with GOLD grade U-II COPD showed that ADC (β = 0.34, P = .04),
Urotensin-ⅡReceptor Antagonist SB-710411 Protects Rat Heart against Ischemia-Reperfusion Injury via RhoA/ROCK Pathway.
Chen et al., Hefei, China. In Plos One, Dec 2015
AIM: SB-710411 is a rat selective urotensin-II (U-II) receptor antagonist, which can block U-II-induced contraction of the aorta and inhibit U-II-induced myocardial fibrosis in rats.
Use of Diverse Chemometric and Validation Methods to Accurately Predict Human Urotensin-II Receptor Antagonist Activity.
Paliwal et al., Tonk, India. In Curr Comput Aided Drug Des, Dec 2015
Despite being identified as the most potent receptor related to vasoconstriction, human urotensin-II receptor (hUT) has not been fully explored as a target for the treatment of cardiovascular diseases.
Urotensin II contributes to collagen synthesis and up-regulates Egr-1 expression in cultured pulmonary arterial smooth muscle cells through the ERK1/2 pathway.
Xu et al., Jinan, China. In Biochem Biophys Res Commun, Dec 2015
AIM: The objective of this study was to investigate the effects of urotensin II (UII) treatment on the proliferation and collagen synthesis of cultured rat pulmonary arterial smooth muscle cells (PASMCs) and to explore whether these effects are mediated by mitogen-activated protein kinase (MAPK) signaling pathways and early growth response 1 (Egr-1).
Unravelling osteoarthritis-related synovial fibrosis: a step closer to solving joint stiffness.
van der Kraan et al., Nijmegen, Netherlands. In Rheumatology (oxford), Nov 2015
In this regard, the following factors are discussed: TGF-β, connective tissue growth factor, procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2, tissue inhibitor of metalloproteinase 1, A disintegrin and metalloproteinase domain 12, urotensin-II, prostaglandin F2α and hyaluronan.
Irisin levels are associated with urotensin II levels in diabetic patients.
Zhang et al., Beijing, China. In J Diabetes Investig, Sep 2015
Previous studies showed that circulating urotensin II (UII) levels were increased in diabetes, and UII could inhibit the glucose transport in skeletal muscle in diabetic mice and aggravated insulin resistance.
Urotensin II Protects Cardiomyocytes from Apoptosis Induced by Oxidative Stress through the CSE/H2S Pathway.
Zou et al., Shanghai, China. In Int J Mol Sci, 2014
Plasma urotensin II (UII) has been observed to be raised in patients with acute myocardial infarction; suggesting a possible cardiac protective role for this peptide.
International Union of Basic and Clinical Pharmacology. XCII. Urotensin II, urotensin II-related peptide, and their receptor: from structure to function.
Vaudry et al., Québec, Canada. In Pharmacol Rev, 2014
Urotensin II (UII) is a cyclic neuropeptide that was first isolated from the urophysis of teleost fish on the basis of its ability to contract the hindgut.
Urotensin-II-Mediated Reactive Oxygen Species Generation via NADPH Oxidase Pathway Contributes to Hepatic Oval Cell Proliferation.
Wang et al., Beijing, China. In Plos One, 2014
Urotensin II (UII), a somatostatin-like cyclic peptide, is involved in tumor progression due to its mitogenic effect.
Autocrine Human Urotensin II Enhances Macrophage-Derived Foam Cell Formation in Transgenic Rabbits.
Liu et al., Xi'an, China. In Biomed Res Int, 2014
Circulating urotensin II (UII) is involved in the development of atherosclerosis.
Molecular evolution of GPCRs: Somatostatin/urotensin II receptors.
Larhammar et al., Uppsala, Sweden. In J Mol Endocrinol, 2014
Somatostatin (SS) and urotensin II (UII) are members of two families of structurally related neuropeptides present in all vertebrates.
Endocrine regulation of prolactin cell function and modulation of osmoreception in the Mozambique tilapia.
Grau et al., Kāne‘ohe, United States. In Gen Comp Endocrinol, 2013
Prolactin release has been shown to be stimulated by gonadotropin-releasing hormone (GnRH), 17-β-estradiol (E2), testosterone (T), thyrotropin-releasing hormone (TRH), atrial natriuretic peptide (ANP), brain-natriuretic peptide (BNP), C-type natriuretic peptide (CNP), ventricular natriuretic peptide (VNP), PRL-releasing peptide (PrRP), angiotensin II (ANG II), leptin, insulin-like growth factors (IGFs), ghrelin, and inhibited by somatostatin (SS), urotensin-II (U-II), dopamine, cortisol, ouabain and vasoactive intestinal peptide (VIP).
Impact of gene/genome duplications on the evolution of the urotensin II and somatostatin families.
Lihrmann et al., Paris, France. In Gen Comp Endocrinol, 2013
The present review describes the molecular evolution of two phylogenetically related families of neuropeptides, the urotensin II (UII) and somatatostatin (SS) families.
Genetic and pharmacological manipulation of urotensin II ameliorate the metabolic and atherosclerosis sequalae in mice.
Schwertani et al., Montréal, Canada. In Arterioscler Thromb Vasc Biol, 2012
role of urotensin II gene deletion in atherosclerosis and suggest that the use of pharmaceutical agents aimed at blocking the urotensin II pathway may provide a novel approach in the treatment of atherosclerosis.
Urotensin upregulates transforming growth factor-β1 expression of asthma airway through ERK-dependent pathway.
Li et al., Wenzhou, China. In Mol Cell Biochem, 2012
The current study provides new evidence that Urotensin II (UII) is involved in the TGF-beta mediated mitogenic effect on ASMCs. UII, at least partially, uses ERK pathway to render such effect.
Urotensin II and urocortin trigger the expression of myostatin, a negative regulator of cardiac growth, in cardiomyocytes.
Bertrand et al., Brussels, Belgium. In Peptides, 2012
The two hypertrophic peptides urotensin II and urocortin stimulate the expression of myostatin.
Endogenous urotensin II selectively modulates erectile function through eNOS.
Sorrentino et al., Napoli, Italy. In Plos One, 2011
U-II elicited penile erection through eNOS activation
Transforming growth factor-β1 involved in urotensin II-induced phenotypic differentiation of adventitial fibroblasts from rat aorta.
Kuang et al., Shantou, China. In Chin Med J (engl), 2010
Transforming growth factor-beta1 involved in urotensin II-induced phenotypic differentiation of adventitial fibroblasts from rat aorta.
Nonclassic endogenous novel [corrected] regulators of angiogenesis.
Nussdorfer et al., Bari, Italy. In Pharmacol Rev, 2007
An in vivo and in vitro proangiogenic effect has been demonstrated for erythropoietin, angiotensin II (ANG-II), endothelins (ETs), adrenomedullin (AM), proadrenomedullin N-terminal 20 peptide (PAMP), urotensin-II, leptin, adiponectin, resistin, neuropeptide-Y, vasoactive intestinal peptide (VIP), pituitary adenylate cyclase-activating polypeptide (PACAP), and substance P.
Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14.
Douglas et al., King of Prussia, United States. In Nature, 1999
Urotensin-II (U-II) is a vasoactive 'somatostatin-like' cyclic peptide which was originally isolated from fish spinal cords, and which has recently been cloned from man.
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