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Guanylate cyclase activator 2B

This gene encodes a member of the guanylin family, and is expressed in the stomach and intestine. This protein functions as an endogenous ligand for the guanylate cyclase-C receptor and stimulates an increase in cyclic GMP, a key component of several intracellular signal transduction pathways. It maybe involved in salt and water secretion into the intestinal lumen as well as the renal tubules, and thus regulate electrolyte homeostasis in these tissues. [provided by RefSeq, Oct 2011] (from NCBI)
Top mentioned proteins: Sar1, GC-C, V1a, ACID, CAN
Papers on uroguanylin
Uroguanylin action in the brain reduces weight gain in obese mice via different efferent autonomic pathways.
Nogueiras et al., Santiago de Compostela, Spain. In Diabetes, Dec 2015
The identification of uroguanylin (UGN), an intestinal released peptide regulated by nutritional status and with anorectic actions, as the endogenous ligand for guanylyl cyclase 2C (GUCY2C) receptor, has revealed a new system in the regulation of energy balance.
Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis.
Plevy et al., United States. In World J Gastrointest Pharmacol Ther, Dec 2015
AIM: To evaluate the effect of orally administered plecanatide or dolcanatide, analogs of uroguanylin, on amelioration of colitis in murine models.
The differential role of renoguanylin in osmoregulation and apical Cl-/HCO3- exchange activity in the posterior intestine of the Gulf toadfish (Opsanus beta).
Grosell et al., Kashiwa, Japan. In Am J Physiol Regul Integr Comp Physiol, Sep 2015
The present findings demonstrate that mRNA from guanylin and uroguanylin, as well as at least one isoform of the guanylin peptide receptor, apical guanylyl cyclase-C (GC-C), was highly expressed in the intestine and rectum of the Gulf toadfish (Opsanus beta).
Emerging treatments in Neurogastroenterology: Perspectives of guanylyl cyclase C agonists use in functional gastrointestinal disorders and inflammatory bowel diseases.
Fichna et al., Łódź, Poland. In Neurogastroenterol Motil, Aug 2015
Endogenous GC-C agonists - guanylin peptides: guanylin and uroguanylin, by the regulation of water and electrolyte transport, are involved in the maintenance of homeostasis in the intestines and integrity of the intestinal mucosa.
Congenital secretory diarrhoea caused by activating germline mutations in GUCY2C.
Visweswariah et al., Innsbruck, Austria. In Gut, Jun 2015
GC-C is an intestinal brush border membrane-bound guanylate cyclase, which functions as receptor for guanylin, uroguanylin and Escherichia coli heat-stable enterotoxin.
Uroguanylin levels in intestine and plasma are regulated by nutritional status in a leptin-dependent manner.
Seoane et al., Santiago de Compostela, Spain. In Eur J Nutr, Apr 2015
PURPOSE: Uroguanylin (UGN) is a 16 amino acid peptide produced mainly by intestinal epithelial cells.
The guanylate cyclase-C signaling pathway is down-regulated in inflammatory bowel disease.
Gustafsson et al., Trondheim, Norway. In Scand J Gastroenterol, 2014
To evaluate GC-C signaling, we examined the regulation of GC-C (GUCY2C/Gucy2c) and its endogenous ligands guanylin (GN/GUCA2A/Guca2a) and uroguanylin (UGN/GUCA2B/Guca2b) in colonic Crohn's disease (CD), ulcerative colitis (UC) and in rats with 2,4,6-Trinitrobenzene sulphonic acid (TNBS) colitis.
Chemostimuli for guanylyl cyclase-D-expressing olfactory sensory neurons promote the acquisition of preferences for foods adulterated with the rodenticide warfarin.
Munger et al., Bridgeport, United States. In Front Neurosci, 2014
After olfactory investigation of a saline droplet containing either cocoa (2%, w/w) or cinnamon (1%, w/w) along with a GC-D+ OSN-specific chemostimulus (either of the guanylin-family peptides uroguanylin and guanylin; 1-50 nM), C57BL/6J mice exhibited robust preferences for unadulterated food containing the demonstrated odor.
Guanylin peptides regulate electrolyte and fluid transport in the Gulf toadfish (Opsanus beta) posterior intestine.
Grosell et al., Tokyo, Japan. In Am J Physiol Regul Integr Comp Physiol, 2014
The physiological effects of guanylin (GN) and uroguanylin (UGN) on fluid and electrolyte transport in the teleost fish intestine have yet to be thoroughly investigated.
Linaclotide: a review of its use in the treatment of irritable bowel syndrome with constipation.
McCormack, North Shore, New Zealand. In Drugs, 2014
Linaclotide (Constella®) is a synthetic 14-amino acid peptide, structurally related to guanylin and uroguanylin, that acts as a potent guanylate cyclase C receptor agonist.
Guanylate cyclase-C/cGMP: an emerging pathway in the regulation of visceral pain.
Silos-Santiago et al., Cambridge, United States. In Front Mol Neurosci, 2013
Activation of guanylate cyclase-C (GC-C) expressed predominantly on intestinal epithelial cells by guanylin, uroguanylin or the closely related GC-C agonist peptide, linaclotide, stimulates generation, and release of cyclic guanosine-3',5'-monophosphate (cGMP).
Natriuretic hormones in brain function.
Lichtstein et al., Jerusalem, Israel. In Front Endocrinol (lausanne), 2013
Natriuretic hormones (NH) include three groups of compounds: the natriuretic peptides (ANP, BNP and CNP), the gastrointestinal peptides (guanylin and uroguanylin), and endogenous cardiac steroids.
Current understanding of guanylin peptides actions.
Sindic, Zagreb, Croatia. In Isrn Nephrol, 2012
Guanylin peptides (GPs) family includes guanylin (GN), uroguanylin (UGN), lymphoguanylin, and recently discovered renoguanylin.
Pendrin, a novel transcriptional target of the uroguanylin system.
Zelikovic et al., Haifa, Israel. In Cell Physiol Biochem, 2012
Guanylin (GN) and uroguanylin (UGN) are low-molecular-weight peptide hormones produced mainly in the intestinal mucosa in response to oral salt load.
The pendrin anion exchanger gene is transcriptionally regulated by uroguanylin: a novel enterorenal link.
Zelikovic et al., Haifa, Israel. In Am J Physiol Renal Physiol, 2012
UGN exerts its inhibitory activity on the prendrin gene promoter likely via heat shock factor 1 action at a defined heat shock element site.
The rat kidney contains high levels of prouroguanylin (the uroguanylin precursor) but does not express GC-C (the enteric uroguanylin receptor).
Goy et al., Chapel Hill, United States. In Am J Physiol Renal Physiol, 2011
these studies provide a comprehensive description of Ugn and GC-C expression in the kidney of the Sprague-Dawley rat.
Uroguanylin, an intestinal natriuretic peptide, is delivered to the kidney as an unprocessed propeptide.
Goy et al., Chapel Hill, United States. In Endocrinology, 2008
Uroguanylin is delivered to the kidney as an unprocessed propeptide.
Circulating prouroguanylin is processed to its active natriuretic form exclusively within the renal tubules.
Goy et al., Chapel Hill, United States. In Endocrinology, 2008
To respond to proUGn released from the gut, any target organ must use a local mechanism for production of active peptide.
Haplotype-based case-control study of the association between the guanylate cyclase activator 2B (GUCA2B, Uroguanylin) gene and essential hypertension.
Usami et al., Tokyo, Japan. In Hypertens Res, 2007
The occurrences of the C-A haplotype (rs883062-rs1047047) and the C-A-G haplotype (rs883062-rs1047047-rs2297566) were significantly higher in the essential hypertension group than in the controls.
The molecular basis of hypertension.
Dubois et al., Dallas, United States. In Annu Rev Biochem, 1998
Next, proteins involved in vasodilation/natriuresis are discussed with emphasis on natriuretic peptides, guanylin/uroguanylin, and nitric oxide.
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