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Uridine phosphorylase 1

uridine phosphorylase, UPP, UPRT
The 2 known types of pyrimidine nucleoside phosphorylases, uridine phosphorylase (UP; EC and thymidine phosphorylase (TP; EC, in the presence of orthophosphate, catalyze the reversible phosphorolysis of uridine and thymidine or deoxyuridine, respectively, to free bases and ribose-1-phosphate or deoxyribose-1-phosphate. Pyrimidine nucleoside phosphorylases can add ribose or deoxyribose to pyrimidine bases to form nucleosides that can be incorporated into RNA or DNA (Watanabe and Uchida, 1995 [PubMed 7488099]).[supplied by OMIM, Aug 2009] (from NCBI)
Top mentioned proteins: Ubiquitin, CAN, ACID, HAD, V1a
Papers on uridine phosphorylase
p97/VCP promotes Cullin-RING-ubiquitin-ligase/proteasome-dependent degradation of IκBα and the preceding liberation of RelA from ubiquitinated IκBα.
Naumann et al., Magdeburg, Germany. In J Cell Mol Med, Jan 2016
While RelA phosphorylation was observed to mediate NF-κB activation independent of Ub-proteasome-pathway (UPP)-dependent turnover of IκBα in some studies, a strict requirement of the p97/VCP ATPase for both, IκBα degradation and NF-κB activation, was reported in others.
The mystery of the fourth clone: comparative genomic analysis of four non-typeable Streptococcus pneumoniae strains with different susceptibilities to optochin.
Govorun et al., Moscow, Russia. In Eur J Clin Microbiol Infect Dis, Jan 2016
Two adjacent genes coding maltose O-acetyltransferase and uridine phosphorylase which were presented in the genomes of all optochin-susceptible strains and missed in the optochin-resistant strain were revealed.
[Mesenchymal stem cells expressing cytosine deaminase inhibit growth of murine melanoma B16F10 in vivo].
Belyavsky et al., Pushchino, Russia. In Mol Biol (mosk), Nov 2015
Mouse adipose tissue-derived MSCs were transfected with plasmid constructs to express cytosine deaminase fused with uracil phosphoribosyltransferase (CDA/UPRT) or CDA/UPRT fused with HSV-1 tegument protein VP22 (CDA/UPRT/VP22).
Production of Infectious Dengue Virus in Aedes aegypti Is Dependent on the Ubiquitin Proteasome Pathway.
Ooi et al., Singapore, Singapore. In Plos Negl Trop Dis, Nov 2015
The dependence on the UPP for successful DENV production is further reinforced by the observed up-regulation of key UPP molecules upon DENV infection that overcome the relatively low expression of these genes after a blood meal.
Proteasome Inhibition Suppresses Dengue Virus Egress in Antibody Dependent Infection.
Ooi et al., Singapore, Singapore. In Plos Negl Trop Dis, Nov 2015
Many studies have identified the ubiquitin proteasome pathway (UPP) to be important for successful DENV production, but how the UPP contributes to DENV life cycle as host factors remains ill defined.
Identification of sensory hair-cell transcripts by thiouracil-tagging in zebrafish.
Nicolson et al., Portland, United States. In Bmc Genomics, 2014
METHODS: We created a transgenic line of zebrafish expressing the T.gondii uracil phospho-ribosyltransferase (UPRT) enzyme specifically in the hair cells of the inner ear and lateral line organ.
Decreased RXRα is Associated with Increased β-Catenin/TCF4 in (56)Fe-Induced Intestinal Tumors.
Datta et al., Washington, D.C., United States. In Front Oncol, 2014
Post-translational β-catenin level is regulated via the adenomatous polyposis coli (APC)-dependent as well as the APC-independent ubiquitin-proteasome pathway (UPP).
Perturbation of cellular proteostasis networks identifies pathways that modulate precursor and intermediate but not mature levels of frataxin.
Bulawa et al., Cambridge, United States. In Sci Rep, 2014
We targeted p97/VCP, the ubiquitin proteasome pathway (UPP), and autophagy with chemical inhibitors in cell lines and patient-derived cells.
The proteasome: mechanisms of biology and markers of activity and response to treatment in multiple myeloma.
Landgren et al., Bethesda, United States. In Leuk Lymphoma, 2014
Since the early 1990s, the synthesis and subsequent clinical application of small molecule inhibitors of the ubiquitin proteasome pathway (UPP) has revolutionized the treatment and prognosis of multiple myeloma.
[Research advance on the role of ubiquitin proteasome pathway in acute promyelocytic leukemia].
Zhou et al., Hangzhou, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, 2014
Ubiquitin proteasome-pathway (UPP) plays a key role in all-trans retinoid acid (ATRA) and arsenic trioxide (ATO)-induced degradation.
An optimal ubiquitin-proteasome pathway in the nervous system: the role of deubiquitinating enzymes.
Todi et al., Detroit, United States. In Front Mol Neurosci, 2013
The Ubiquitin-Proteasome Pathway (UPP), which is critical for normal function in the nervous system and is implicated in various neurological diseases, requires the small modifier protein ubiquitin to accomplish its duty of selectively degrading short-lived, abnormal or misfolded proteins.
Local ubiquitin-proteasome-mediated proteolysis and long-term synaptic plasticity.
Beckelman et al., Winston-Salem, United States. In Front Mol Neurosci, 2013
The ubiquitin-proteasome pathway (UPP) of protein degradation has many roles in synaptic plasticity that underlies memory.
The functional logic of cytosolic 5'-nucleotidases.
Balestri et al., Pisa, Italy. In Curr Med Chem, 2012
Intracellular balance of nucleosides is maintained by the action of several enzymes, such as adenosine deaminase, uridine phosphorylase and cytidine deaminase, and by at least three 5'-nucleotidases, the ADP activated AMP preferring cN-IA, the ATP-ADP activated IMP-GMP preferring cN-II, and the UMP-CMP preferring cN-III.
Differential expression of uridine phosphorylase in tumors contributes to an improved fluoropyrimidine therapeutic activity.
Pizzorno et al., Springfield, United States. In Mol Cancer Ther, 2011
Importance of UPase in the activation of fluoropyrimidines, the effect of uridine in protecting normal tissues, and the role for tumor-specific modulation of the phosphorolytic activity in 5-FU or capecitabine-based chemotherapy.
Active site conformational dynamics in human uridine phosphorylase 1.
Castronovo et al., Las Vegas, United States. In Plos One, 2009
The dimeric enzyme is capable of a large hinge motion facilitating ligand exchange.
Enhanced cytotoxicity of 5-FU by bFGF through up-regulation of uridine phosphorylase 1.
Choi et al., Ch'ŏngju, South Korea. In Mol Cells, 2009
Data show that enhanced cytotoxicity of 5-FU by bFGF through modulating the expression of UPP1 at the transcription level.
TU-tagging: cell type-specific RNA isolation from intact complex tissues.
Doe et al., Eugene, United States. In Nat Methods, 2009
We found that the combination of spatially restricted uracil phosphoribosyltransferase (UPRT) expression with 4-thiouracil delivery can be used to label and purify cell type-specific RNA from intact complex tissues in Drosophila melanogaster.
Unbalanced deoxynucleotide pools cause mitochondrial DNA instability in thymidine phosphorylase-deficient mice.
Hirano et al., New York City, United States. In Hum Mol Genet, 2009
Thymidine phosphorylase and UPP1 double knockout mice showed increased thymidine and deoxyuridine in tissues and developed encephalopathy.
Implications of the structure of human uridine phosphorylase 1 on the development of novel inhibitors for improving the therapeutic window of fluoropyrimidine chemotherapy.
Pizzorno et al., Las Vegas, United States. In Bmc Struct Biol, 2008
The presented structures confirm that hUPP1 is dimeric. They also reveal the mechanism by which 5-benzylacyclouridine engages the active site of the protein and disables the enzyme by locking the protein in a closed conformation.
Biosynthetic labeling of RNA with uracil phosphoribosyltransferase allows cell-specific microarray analysis of mRNA synthesis and decay.
Boothroyd et al., In Nat Biotechnol, 2005
We have developed a method to overcome this limitation by using the salvage enzyme uracil phosphoribosyltransferase (UPRT) from the protozoan Toxoplasma gondii.
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