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Uridine-cytidine kinase 2

Uridine Kinase, uridine monophosphate kinase, UMPK
This gene encodes a pyrimidine ribonucleoside kinase. The encoded protein (EC catalyzes phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP), respectively.[provided by RefSeq, Oct 2010] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, V1a, STEP
Papers on Uridine Kinase
Anaplasma phagocytophilum Rab10-dependent parasitism of the trans-Golgi network is critical for completion of the infection cycle.
Carlyon et al., Richmond, United States. In Cell Microbiol, Feb 2016
The A. phagocytophilum surface protein, uridine monophosphate kinase, was identified as a guanine nucleotide-independent, Rab10-specific ligand.
RAP-PCR fingerprinting reveals time-dependent expression of development-related genes following differentiation process of Bacillus thuringiensis.
Guan et al., Fuzhou, China. In Can J Microbiol, Sep 2015
RAP5 showed significant homology to a uridine kinase that mediates phosphorylation of uridine and azauridine.
The structural basis of ATP as an allosteric modulator.
Zhang et al., Shanghai, China. In Plos Comput Biol, 2014
Nudged elastic band simulations unveiled the distinct dynamic processes of ATP binding to the corresponding allosteric and substrate binding sites of uridine monophosphate kinase, and suggested that in solution ATP preferentially binds to the substrate binding sites of proteins.
Construction of an inducible system for the analysis of essential genes in Yersinia pestis.
Oyston et al., Salisbury, United Kingdom. In J Microbiol Methods, 2014
Using this approach, we have confirmed the uridine monophosphate kinase PyrH as an essential protein in Y. pestis.
Nucleoside kinases in adult Schistosoma mansoni: phosphorylation of pyrimidine nucleosides.
El Kouni et al., Birmingham, United States. In Mol Biochem Parasitol, 2014
Competition studies and column chromatography demonstrated that adults Schistosoma mansoni contains three nucleoside kinases that can phosphorylate pyrimidine nucleosides; a non-specific deoxyriboside kinase (EC, a specific uridine kinase and a specific cytidine kinase.
Uridine monophosphate kinase as potential target for tuberculosis: from target to lead identification.
Mohan et al., India. In Interdiscip Sci, 2013
Critical analysis of these proteins using Kyoto Encyclopedia of Genes and Genomes (KEGG) metabolic pathways database revealed uridine monophosphate kinase (UMPK) enzyme as a potential drug target for developing novel anti-TB drugs.
Pyrimidine homeostasis is accomplished by directed overflow metabolism.
Rabinowitz et al., Princeton, United States. In Nature, 2013
The mechanism involves cooperative feedback regulation of the near-terminal pathway enzyme uridine monophosphate kinase.
Predictive markers of capecitabine sensitivity identified from the expression profile of pyrimidine nucleoside-metabolizing enzymes.
Mori et al., Kamakura, Japan. In Oncol Rep, 2013
A clustering analysis revealed that the 12 enzymes were divided into two groups; one group consisted of 8 enzymes, including orotate phosphoribosyl transferase (OPRT), TMP kinase (TMPK) and UMP kinase (UMPK), and was related to the de novo synthesis pathway for nucleotides, with mRNA expression levels showing significant mutual correlation.
Quantum mechanics/molecular mechanics investigation of the mechanism of phosphate transfer in human uridine-cytidine kinase 2.
Houk et al., Los Angeles, United States. In Org Biomol Chem, 2009
The mechanism of phosphate transfer in UCK2 is shown to be concerted, and is accompanied by concerted proton transfer from the 5'-hydroxyl to a conserved active site aspartic acid that serves as a catalytic base
Tiling resolution array comparative genomic hybridization, expression and methylation analyses of dup(1q) in Burkitt lymphomas and pediatric high hyperdiploid acute lymphoblastic leukemias reveal clustered near-centromeric breakpoints and overexpression of genes in 1q22-32.3.
Johansson et al., Lund, Sweden. In Hum Mol Genet, 2007
B4GALT3, DAP3, RGS16, TMEM183A and UCK2--were significantly overexpressed in dup(1q)-positive ALLs compared with high hyperdiploid ALLs without dup(1q).
Assignment of UCK2, ATF3 and RGS18 from human chromosome 1 to porcine chromosomes 4, 9 and 10 with somatic and radiation hybrid panels.
Moran et al., Sydney, Australia. In Cytogenet Genome Res, 2005
gene mapped to chromosome 1.
Genetic factors influencing pyrimidine-antagonist chemotherapy.
de Vries et al., Meppel, Netherlands. In Pharmacogenomics J, 2004
Germline polymorphisms of uridine monophosphate kinase (UMPK), orotate phosphoribosyl transferase (OPRT), thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD) and methylene tetrahydrofolate reductase (MTHFR) and gene expression levels of OPRT, UMPK, TS, DPD, uridine phosphorylase, uridine kinase, thymidine phosphorylase, thymidine kinase, deoxyuridine triphosphate nucleotide hydrolase are discussed in relation to 5-FU efficacy.
A crucial role of uridine/cytidine kinase 2 in antitumor activity of 3'-ethynyl nucleosides.
Sasaki et al., Kanazawa, Japan. In Drug Metab Dispos, 2004
UCK2 is responsible for phosphorylation and activation of the antitumor activity of 3'-ethynyl nucleosides 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)cytosine and 1-(3-C-ethynyl-beta-D-ribopentofuranosyl)uridine.
Epstein-Barr virus encoded nuclear protein EBNA-3 binds a novel human uridine kinase/uracil phosphoribosyltransferase.
Szekely et al., Stockholm, Sweden. In Bmc Cell Biol, 2002
Increased intranuclear levels of UK may contribute to the metabolic build-up that is needed for Epstein-Barr virus nuclear protein EBNA-3-mediated B-cell blast transformation and rapid proliferation.
Novel aspects of resistance to drugs targeted to dihydrofolate reductase and thymidylate synthase.
Bertino et al., New York City, United States. In Biochim Biophys Acta, 2002
The enzyme uridine-cytidine monophosphate kinase (UMPK) is an essential and rate-limiting enzyme in 5-FU activation while dihydropyrimidine dehydrogenase (DPD) is a catabolic enzyme that inactivates 5-FU.
Development of inhibitors of pyrimidine metabolism.
Cha, In Yonsei Med J, 1989
These compounds have no activity against thymidine phosphorylase, uridine kinase, thymidine kinase and orotate phosphoribosyltransferase. Benzylacyclouridines potentiate the chemotherapeutic effect of FdUrd.
Uridine monophosphate kinase 3: a genetic marker for susceptibility to Haemophilus influenzae type B disease.
Ward et al., In Lancet, 1985
In this population a polymorphic genetic variant of the pyrimidine pathway enzyme, uridine monophosphate kinase-3 (UMPK-3), was found to be positively associated with invasive Hib disease (relative risk 3.3) and a tendency towards a younger age at onset of illness.
Biology of cardiac overload.
Delcayre et al., In Pathobiol Annu, 1981
Among the very early events which could be potential signals for protein synthesis, attention has been focused on polyamine, RNA polymerase, and uridine kinase.
Intestinal enzymes: indicators of proliferation and differentiation in the jejunum.
Kretchmer et al., In Science, 1970
Some intestinal enZymes were assayed which were related to: (i) Cellular proliferation, for example, aspartate carbamoyltransferase, thymidine kinase, uridine kinase, and dihydroorotase; (ii) cellular differentiation, for example, lactase, invertase, maltase, alkaline phosphatase, and dipeptidase; and (iii) lysosomes, for example, beta-glucuronidase, acid beta-galactosidase, and acid phosphatase.
Pyrimidine nucleotide synthesis: regulatory control during transformation of lymphocytes in vitro.
Lucas, In Science, 1967
The incorporation of uridine into RNA in lymphocytes undergoing transformation induced by phytohemagglutinin parallels its incorporation into the intratcellular pool of acid-soluble nucleotides and coincides with a 20-fold increase in the specific activity of uridine kinase.
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