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UPF1 regulator of nonsense transcripts homolog

UPF1, hUpf1, Rent1
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: caspase-3, UPF2, UPF3, CAN, LIP
Papers on UPF1
Nonsense-mediated mRNA decay in humans at a glance.
Maquat et al., Rochester, United States. In J Cell Sci, Feb 2016
In this Cell Science at a Glance and the accompanying poster, we review progress made towards this goal, focusing on human studies and the role of the key NMD factor up-frameshift protein 1 (UPF1).
Polypyrimidine tract binding protein 1 protects mRNAs from recognition by the nonsense-mediated mRNA decay pathway.
Hogg et al., Bethesda, United States. In Elife, Feb 2016
When bound near a stop codon, PTBP1 blocks the NMD protein UPF1 from binding 3'UTRs.
Human nonsense-mediated mRNA decay factor UPF2 interacts directly with eRF3 and the SURF complex.
Llorca et al., Madrid, Spain. In Nucleic Acids Res, Feb 2016
According to prevailing models, NMD begins by the assembly of the SURF (SMG1-UPF1-eRF1-eRF3) complex at the ribosome, followed by UPF1 activation by additional factors such as UPF2 and UPF3.
Insulin Signaling Augments eIF4E-Dependent Nonsense-Mediated mRNA Decay in Mammalian Cells.
Hwang et al., Seoul, South Korea. In Biochim Biophys Acta, Jan 2016
We provide evidence that (i) insulin-mediated enhancement of translation augments NMD and rapamycin abrogates this enhancement; (ii) an increase in AKT phosphorylation due to inhibition of PTEN facilitates NMD; (iii) insulin stimulation increases the binding of up-frameshift factor 1 (UPF1), most likely to eIF4E-bound PTC-containing transcripts; and (iv) insulin stimulation induces the colocalization of UPF1 and eIF4E in processing bodies.
A novel role for CARM1 in promoting nonsense-mediated mRNA decay: potential implications for spinal muscular atrophy.
Côté et al., Ottawa, Canada. In Nucleic Acids Res, Jan 2016
We further show that CARM1 associates with major NMD factor UPF1 and promotes its occupancy on PTC-containing transcripts.
The human RNA surveillance factor UPF1 regulates tumorigenesis by targeting Smad7 in hepatocellular carcinoma.
Liu et al., Wuhan, China. In J Exp Clin Cancer Res, Dec 2015
In this investigation we studied the role of Up-frameshift 1 (UPF1) in the tumorigenesis of HCC.
Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms.
Takeuchi et al., Kyoto, Japan. In Cell, Jun 2015
Moreover, Regnase-1 specifically cleaves and degrades translationally active mRNAs and requires the helicase activity of UPF1, similar to the decay mechanisms of nonsense mRNAs.
Degradation of oligouridylated histone mRNAs: see UUUUU and goodbye.
Heissmeyer et al., München, Germany. In Wiley Interdiscip Rev Rna, 2014
Presumably in cooperation with LSM1-7 and aided by the helicase UPF1, ERI1 degrades through the stem-loop of oligouridylated histone mRNAs in repeated rounds of partial degradation and reoligouridylation.
The UPF1 RNA surveillance gene is commonly mutated in pancreatic adenosquamous carcinoma.
Lu et al., Shanghai, China. In Nat Med, 2014
Here we report that ASC tumors frequently harbor somatically acquired mutations in the UPF1 gene, which encodes the core component of the nonsense-mediated RNA decay (NMD) pathway.
Affinity proteomics reveals human host factors implicated in discrete stages of LINE-1 retrotransposition.
Dai et al., Baltimore, United States. In Cell, 2013
Among the findings, UPF1, a key nonsense-mediated decay factor, and PCNA, the polymerase-delta-associated sliding DNA clamp, were identified and validated.
Staufen-mediated mRNA decay.
Maquat et al., Rochester, United States. In Wiley Interdiscip Rev Rna, 2013
Both STAU1 and STAU2 interact directly with the ATP-dependent RNA helicase UPF1, a key SMD factor, enhancing its helicase activity to promote effective SMD.
Nonsense-mediated mRNA decay - mechanisms of substrate mRNA recognition and degradation in mammalian cells.
Mühlemann et al., Bern, Switzerland. In Biochim Biophys Acta, 2013
In addition, the central role of UPF1, its crucial phosphorylation/dephosphorylation cycle and dynamic interactions with other NMD factors are discussed.
Control of somatic tissue differentiation by the long non-coding RNA TINCR.
Khavari et al., Stanford, United States. In Nature, 2013
Loss of UPF1 and UPF2, both of which are required for STAU1-mediated RNA decay, however, did not have differentiation effects.
UPF1 involvement in nuclear functions.
Brogna et al., Birmingham, United Kingdom. In Biochem Soc Trans, 2012
UPF1 (up-frameshift 1) is a protein conserved in all eukaryotes that is necessary for NMD (nonsense-mediated mRNA decay).
The human T-lymphotropic virus type 1 tax protein inhibits nonsense-mediated mRNA decay by interacting with INT6/EIF3E and UPF1.
Jalinot et al., Lyon, France. In J Virol, 2012
HTLV-1 Tax binds to UPF1 and causes an increase in the amount of phospho-UPF1. These activities coincidewith an enhanced localization of UPF1 in the P-bodies, in which Tax was also partially detected
The cryo-EM structure of the UPF-EJC complex shows UPF1 poised toward the RNA 3' end.
Llorca et al., Madrid, Spain. In Nat Struct Mol Biol, 2012
The heptameric assembly of the UPF complex is built around UPF2, a scaffold protein with a ring structure that closes around the CH domain of UPF1, keeping the helicase region in an accessible and unwinding-competent state.
Up-frameshift protein 1 (UPF1): multitalented entertainer in RNA decay.
Akimitsu et al., Tokyo, Japan. In Drug Discov Ther, 2012
UPF1 is an important factor for the RNA quality control system and the regulation of physiological gene expression, and contributes to DNA replication, DNA repair, telomere metabolism, and stabilization of HIV-1 genomic RNA.
Arabidopsis plants having defects in nonsense-mediated mRNA decay factors UPF1, UPF2, and UPF3 show photoperiod-dependent phenotypes in development and stress responses.
Wu et al., Jena, Germany. In J Integr Plant Biol, 2012
The involvement of UPF1, UPF2, and UPF3 in development and in response to stresses, wounding and infection by Pseudomonas syringae pv. tomato strain DC3000, were examined.
Cell type-dependent gene regulation by Staufen2 in conjunction with Upf1.
Yoneda et al., Suita, Japan. In Bmc Mol Biol, 2010
Recruitment of Stau2 alone or in combination with Upf1 differentially affects the fate of mRNAs.
Translational control of intron splicing in eukaryotes.
Meyer et al., Rouen, France. In Nature, 2008
By knocking down the two P. tetraurelia genes encoding UPF1, a protein that is crucial in NMD, we show that the intrinsic efficiency of splicing varies widely among introns and that NMD activity can significantly reduce the fraction of unspliced mRNAs.
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