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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Unc-5 homolog A

a netrin receptor involved in neuronal migration [RGD, Feb 2006] (from NCBI)
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Top mentioned proteins: netrin-1, DCC, UNC5B, UNC5C, V1a
Papers on UNC5H1
Netrin-1 induces the migration of Schwann cells via p38 MAPK and PI3K-Akt signaling pathway mediated by the UNC5B receptor.
Zhao et al., Tianjin, China. In Biochem Biophys Res Commun, Sep 2015
QRT-PCR indicated that Netrin-1 and only its receptors Unc5a, Unc5b and Neogenin were expressed in RSC96 cells, among which Unc5b expressed the most.
The crystal structure of netrin-1 in complex with DCC reveals the bifunctionality of netrin-1 as a guidance cue.
Meijers et al., Beijing, China. In Neuron, 2014
Furthermore, we demonstrate that UNC5A can replace DCC on the generic receptor binding site to switch the response from attraction to repulsion.
DNA damage-inducible gene, UNC5A, functions as a tumor-suppressor in bladder cancer.
Bi et al., Shenyang, China. In Tumour Biol, 2014
UNC5 receptors are putative tumor suppressors whose expressions are lost in some cancers, but the role of UNC5A during DNA damage in bladder cancer remains undefined.
Expression of netrin-1 receptors in retina of oxygen-induced retinopathy in mice.
Xia et al., Changsha, China. In Bmc Ophthalmol, 2013
RESULTS: RT-PCR results showed that, except for UNC5A, netrin-1 receptor subtypes UNC5B, UNC5C, UNC5D, DCC, neogenin, and A2b were all expressed in the retinas of OIR mice 17 days after birth.
The Fanconi anemia group C protein interacts with uncoordinated 5A and delays apoptosis.
Carreau et al., Québec, Canada. In Plos One, 2013
We performed a yeast two-hybrid screen with caspase-mediated FANCC cleavage products and identified the dependence receptor uncoordinated-5A (UNC5A) protein.
Spatiotemporal expression of repulsive guidance molecules (RGMs) and their receptor neogenin in the mouse brain.
Pasterkamp et al., Utrecht, Netherlands. In Plos One, 2012
To fill this void and to gain further insight into the role of RGM-Neogenin signaling during mouse neural development, we studied the expression of RGMa, RGMb, Neogenin and Unc5A-D using in situ hybridization, immunohistochemistry and RGMa section binding.
Netrin-1 simultaneously suppresses corneal inflammation and neovascularization.
Liu et al., Xiamen, China. In Invest Ophthalmol Vis Sci, 2012
METHODS: The expression of netrin-1 and its receptors UNC5A, UNC5B, UNC5C, UNC5D, adenosine 2b receptor (A2BAR), deleted in colorectal cancer (DCC), and neogenin in normal and alkali-burned rat cornea were determined by RT-PCR and/or Western blot analysis, or immunostaining.
Schwann cells direct peripheral nerve regeneration through the Netrin-1 receptors, DCC and Unc5H2.
Zochodne et al., Edmonton, Canada. In Glia, 2011
Unc5H Receptors have Prominent Expression in Adult Schwann cells.
FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neurons.
Egea et al., Martinsried, Germany. In Embo J, 2011
Netrin-1 induces repulsive axon guidance by binding to the mammalian Unc5 receptor family (Unc5A-Unc5D).
Hypoxia-inducible factor 1 controls the expression of the uncoordinated-5-B receptor, but not of netrin-1, in first trimester human placenta.
de Mazancourt et al., Poissy, France. In Int J Dev Biol, 2010
Uncoordinated-5 homologs 1-4 (UNC5H1-4) transmembrane netrin receptors are reported to control a number of cellular processes, including axonal guidance, angiogenesis and cell proliferation.
Identification of UNC5A as a novel transcriptional target of tumor suppressor p53 and a regulator of apoptosis.
Arakawa et al., Tokyo, Japan. In Int J Oncol, 2010
UNC5A is a novel transcriptional target of p53 and plays a role in p53-dependent apoptosis
The ratio of 'deleted in colorectal cancer' to 'uncoordinated-5A' netrin-1 receptors on the growth cone regulates mossy fibre directionality.
Koyama et al., Tokyo, Japan. In Brain, 2010
Hyperactivity increases the surface expression of uncoordinated-5A (Unc5a), which is suppressed by blocking cyclic adenosine monophosphate signaling.
Peri-pubertal emergence of UNC-5 homologue expression by dopamine neurons in rodents.
Flores et al., Montréal, Canada. In Plos One, 2009
Findings suggest that DCC:UNC5H ratios in DA neurons at critical periods may have important consequences for the organization and function of mesocorticolimbic DA systems.
The netrin protein family.
Kennedy et al., Montréal, Canada. In Genome Biol, 2008
Receptors for the secreted netrins include the Deleted in Colorectal Cancer (DCC) family, the Down's syndrome cell adhesion molecule (DSCAM), and the UNC-5 homolog family: Unc5A, B, C and D in mammals.
Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B.
Ye et al., Atlanta, United States. In Nat Cell Biol, 2008
Both UNC5 (that is, UNC5A, UNC5B, UNC5C or UNC5D) and DCC are transmembrane receptors for netrin-1 (Refs 8, 9).
Netrins and their receptors.
Kennedy et al., Montréal, Canada. In Adv Exp Med Biol, 2006
Receptors for the secreted netrins include DCC (deleted in colorectal cancer) and the UNC5 homologues: UNC5A, B, C and D in mammals.
UNC5A promotes neuronal apoptosis during spinal cord development independent of netrin-1.
Hinck et al., Santa Cruz, United States. In Nat Neurosci, 2006
Results suggest that UNC5A promotes neuronal apoptosis during spinal cord development independent of netrin-1.
RumMAGE-D the members: structure and function of a new adaptor family of MAGE-D proteins.
Watanabe et al., Sapporo, Japan. In J Recept Signal Transduct Res, 2004
MAGE-D1, also known as NRAGE or Dlxin-1, functions as an adaptor protein that mediates multiple signaling pathways, including NGFR (p75NTR) and UNC5H1-induced apoptosis and Dlx/Msx-mediated transcription.
Netrin-1 and its receptors in tumorigenesis.
Arakawa, Tokyo, Japan. In Nat Rev Cancer, 2004
UNC5 orthologues define a new mechanism for both the positive (induction) and negative (suppression) regulation of apoptosis in cancer cells (review)
Ten years on: mediation of cell death by the common neurotrophin receptor p75(NTR).
Bredesen et al., Novato, United States. In Cytokine Growth Factor Rev, 2003
Thus, p75(NTR) may function as a death receptor-similar to Fas or TNFR I-or a dependence receptor-similar to deleted in colorectal cancer (DCC) or uncoordinated gene-5 homologues 1-3 (UNC5H1-3).
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