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Unc-5 homolog B

UNC5B, UNC5H2, p53RDL1
This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011] (from NCBI)
Top mentioned proteins: netrin-1, DCC, UNC5H1, UNC5C, V1a
Papers on UNC5B
Lack of netrin-4 modulates pathologic neovascularization in the eye.
Joussen et al., Berlin, Germany. In Sci Rep, Dec 2015
Expression of netrin receptors, Unc5H2 (Unc-5 homolog B, C. elegans) and DCC (deleted in colorectal carcinoma), was found in Müller cells and astrocytes.
Netrin-1 Contributes to Myelinated Afferent Fiber Sprouting and Neuropathic Pain.
Li et al., Wuhan, China. In Mol Neurobiol, Nov 2015
After RTX treatment, UNC5H2 expression was gradually decreased, whereas DCC expression was significantly increased.
Guidance Receptors in the Nervous and Cardiovascular Systems.
Tkachuk et al., Moscow, Russia. In Biochemistry (mosc), Oct 2015
Guidance molecules include Ephrins and their receptors, Neuropilins and Plexins as receptors for Semaphorins, Robos as receptors for Slit-proteins, and UNC5B receptors binding Netrins.
Netrin-1 overexpression in bone marrow mesenchymal stem cells promotes functional recovery in a rat model of peripheral nerve injury.
Mao et al., Zhenjiang, China. In J Biomed Res, Sep 2015
At day 7, 14 and 28 after injection, we measured motor nerve conduction and detected mRNA expressions of netrin-1 receptors UNC5B and Deleted in Colorectal Cancer (DCC), and neurotrophic factors brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) by real-time PCR.
[Preparation of a uncoordinated-5 homolog B monoclonal antibody and its effect on melanoma cell migration in vitro].
Zhao et al., Suzhou, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, Sep 2015
OBJECTIVE: To prepare and characterize the monoclonal antibody (mAb) against uncoordinated-5 homolog B (UNC5B) and analyze its effect on the migration of melanoma cells.
Transcriptomic analysis of pancreatic cancer cells in response to metformin and aspirin: an implication of synergy.
Tan et al., United States. In Sci Rep, 2014
Of the top 10 genes (fold-change > 10, P < 10(-10)) regulated by metformin plus aspirin, PCDH18, CCL2, RASL11A, FAM111B and BMP5 were down-regulated ≥ 20-fold, while NGFR, NPTX1, C7orf57, MRPL23AS1 and UNC5B were up-regulated ≥ 10-fold.
Netrin-1 regulates somatic cell reprogramming and pluripotency maintenance.
Lavial et al., Lyon, France. In Nat Commun, 2014
Our work also sheds light on Netrin-1's function in protecting embryonic stem cells from apoptosis mediated by its receptor UNC5b, and shows that the treatment with recombinant Netrin-1 improves the generation of mouse and human iPS cells.
Guidance cue netrin-1 and the regulation of inflammation in acute and chronic kidney disease.
Ramesh et al., Augusta, United States. In Mediators Inflamm, 2013
The ability of the guidance molecule netrin-1 to repulse or abolish attraction of neuronal cells expressing the UNC5B receptor makes it an attractive candidate for the regulation of inflammatory cell migration.
Role of ROBO4 signalling in developmental and pathological angiogenesis.
Narayan et al., Benares, India. In Biomed Res Int, 2013
This review explores the interactions SLIT2/ROBO1, SLIT2/ROBO1-ROBO4, ROBO1/ROBO4, and ROBO4/UNC5B which can be promising and potential therapeutic targets for developmental angiogenesis defects and pathological angiogenesis.
The neuroimmune guidance cue netrin-1 promotes atherosclerosis by inhibiting the emigration of macrophages from plaques.
Moore et al., New York City, United States. In Nat Immunol, 2012
Acting via its receptor, UNC5b, netrin-1 inhibited the migration of macrophages directed by the chemokines CCL2 and CCL19, activation of the actin-remodeling GTPase Rac1 and actin polymerization.
Clinical significance of UNC5B expression in colorectal cancer.
Sugihara et al., Tokyo, Japan. In Int J Oncol, 2012
The mRNA expression analysis using tissue samples revealed that UNC5B mRNA was down-expressed in about 20% of CRC patients, and the patients with low-UNC5B-expression tumors showed a significantly higher recurrence rate after curative surgery.
Shear stress, tip cells and regulators of endothelial migration.
Bicknell et al., Birmingham, United Kingdom. In Biochem Soc Trans, 2011
However, the recent identification of Unc5B as a Robo4 ligand has increased our understanding and we hypothesize that Robo4 function is context-dependent.
Effects of treadmill exercise on the expression of netrin-1 and its receptors in rat brain after cerebral ischemia.
Du et al., Fuzhou, China. In Neuroscience, 2011
Treadmill exercise has beneficial effects via involvement of netrin-1 and its receptors DCC and Unc5B in neuronal and vascular activities in brain-ischemic rats.
Robo4 maintains vessel integrity and inhibits angiogenesis by interacting with UNC5B.
Eichmann et al., San Francisco, United States. In Dev Cell, 2011
Robo4 specifically binds to UNC5B, a vascular Netrin receptor, revealing unexpected interactions between two endothelial guidance receptors.
The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase.
Mehlen et al., Lyon, France. In Mol Cell, 2011
The recruitment of PP2A to UNC5H2/B allows the activation of DAPk via a PP2A-mediated dephosphorylation and that this mechanism is involved in angiogenesis regulation.
Hypoxia-inducible factor 1 controls the expression of the uncoordinated-5-B receptor, but not of netrin-1, in first trimester human placenta.
de Mazancourt et al., Poissy, France. In Int J Dev Biol, 2010
Hypoxia-inducible factor 1 controls the expression of the uncoordinated-5-B receptor, but not of netrin-1, in first trimester human placenta
Regulation of leukocyte function by adenosine receptors.
Linden, Los Angeles, United States. In Adv Pharmacol, 2010
A(2B)R activation also influences macrophage and neutrophil function by influencing expression of the anti-inflammatory netrin receptor, UNC5B.
Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B.
Ye et al., Atlanta, United States. In Nat Cell Biol, 2008
PIKE-L acts as a downstream survival effector for netrin-1 through UNC5B in the nervous system
The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system.
Eichmann et al., Stanford, United States. In Nature, 2004
Disruption of the Unc5b or netrin-1a leads to aberrant extension of endothelial tip cell filopodia, excessive vessel branching and abnormal navigation
p53RDL1 regulates p53-dependent apoptosis.
Arakawa et al., Tokyo, Japan. In Nat Cell Biol, 2003
Here we report a new p53 target-gene, designated p53RDL1 (p53-regulated receptor for death and life; also termed UNC5B).
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