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Unc-119 homolog

UNC119, HRG4, NRG4, RG4
This gene is specifically expressed in the photoreceptors in the retina. The encoded product shares strong homology with the C. elegans unc119 protein and it can functionally complement the C. elegans unc119 mutation. It has been localized to the photoreceptor synapses in the outer plexiform layer of the retina, and suggested to play a role in the mechanism of photoreceptor neurotransmitter release through the synaptic vesicle cycle. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ROD, ErbB4, HAD, Epidermal Growth Factor
Papers using UNC119 antibodies
NuMA-related LIN-5, ASPM-1, calmodulin and dynein promote meiotic spindle rotation independently of cortical LIN-5/GPR/Galpha
Srayko Martin et al., In The Journal of Cell Biology, 2008
... unc-119(ed3)abcIs3[pie-1-ebp-2–gfp;unc-119(+)]; Video 4) or transgenic worms expressing fluorescent markers ...
Papers on UNC119
Specificity of Lipoprotein Chaperones for the Characteristic Lipidated Structural Motifs of their Cognate Lipoproteins.
Waldmann et al., Dortmund, Germany. In Chembiochem, Nov 2015
In contrast, UNC119 proteins bind only mono-N-myristoylated, but do not recognise doubly lipidated and S-isoprenylated peptides at the C terminus.
Long-term cancer control outcomes in patients with clinically high-risk prostate cancer treated with robot-assisted radical prostatectomy: results from a multi-institutional study of 1100 patients.
Menon et al., Detroit, United States. In Eur Urol, Sep 2015
Regression tree analysis stratified patients into five novel RGs): RG1, very low risk (GS ≤6); RG2, low risk (PSA ≤10 ng/ml; GS: 7); RG3, intermediate risk (PSA ≤10 ng/ml; GS ≥8); RG4, high risk (PSA >10 ng/ml; GS: 7); RG5, very high risk (PSA >10 ng/ml; GS ≥8).
20 Years of unc-119 as a transgene marker.
Maduro, Riverside, United States. In Worm, Jul 2015
This fall marks 20 years since the cloning of unc-119 was reported.
Center for International Blood and Marrow Transplant Research chronic graft-versus-host disease risk score predicts mortality in an independent validation cohort.
Flowers et al., Barcelona, Spain. In Biol Blood Marrow Transplant, Apr 2015
According to the sum of the overall risk score (range, 1 to 12), patients were assigned to 4 risk groups (RGs): RG1 (0 to 2), RG2 (3 to 6), RG3 (7 to 8), and RG4 (9 to 10).
NRG4: an endocrine link between brown adipose tissue and liver.
Pfeifer, Bonn, Germany. In Cell Metab, Feb 2015
(2014) now report that BAT controls liver lipogenesis via secretion of the growth factor NRG4.
Transcriptional fingerprinting of "browning" white fat identifies NRG4 as a novel adipokine.
Christian, Coventry, United Kingdom. In Adipocyte, 2015
Neuregulin 4 was categorized as a cold-induced BAT gene encoding an adipokine that signals between adipocytes and nerve cells and likely to have a role in increasing adipose tissue innervation in response to cold.
Membrane protein transport in photoreceptors: the function of PDEδ: the Proctor lecture.
Baehr, Salt Lake City, United States. In Invest Ophthalmol Vis Sci, 2014
Alfred Wittinghofer's group in Germany showed that PDEδ forms an immunoglobulin-like β-sandwich fold that is closely related in structure to other lipid-binding proteins, for example, Uncoordinated 119 (UNC119) and RhoGDI.
Highly expressed UNC119 promotes hepatocellular carcinoma cell proliferation through Wnt/β-catenin signaling and predicts a poor prognosis.
Liu et al., Cangzhou, China. In Am J Cancer Res, 2014
UNC119, also known as Retinal Protein 4 (HRG4) is significantly up-regulated in hepatocellular carcinoma (HCC) tissues.
Differential Gene Expression in Colon Tissue Associated With Diet, Lifestyle, and Related Oxidative Stress.
Wolff et al., Salt Lake City, United States. In Plos One, 2014
Recent use of aspirin and/or ibuprofen was associated with differential expression of TMC06, ST8SIA4, and STEAP3 while a summary oxidative balance score (OBS) was associated with SYCP3, HDX, and NRG4 (all up-regulated with greater oxidative balance).
Somatic expression of unc-54 and vha-6 mRNAs declines but not pan-neuronal rgef-1 and unc-119 expression in aging Caenorhabditis elegans.
Ignatova et al., Potsdam, Germany. In Sci Rep, 2014
We analyzed the mRNA steady-state levels of polyCAG-encoding transgenes and endogenous genes under the control of well-characterized promoters for intestinal (vha-6), muscular (unc-54, unc-15) and pan-neuronal (rgef-1, unc-119) expression in the nematode Caenorhabditis elegans.
Neuregulin signaling in pieces--evolution of the gene family.
Marchionni, Arlington, United States. In Curr Pharm Des, 2013
First appearance of ancestral NRG, represented in a NRG4-like gene in the lancelet Branchiostoma floridae, appears to have: 1) occurred in the common chordate ancestor prior to the divergence of lancelets (amphioxus), and; 2) antedated the formation of the receptor gene family.
Uncoordinated (UNC)119: coordinating the trafficking of myristoylated proteins.
Baehr et al., Salt Lake City, United States. In Vision Res, 2013
UNC119 polypeptides feature an immunoglobulin-like β-sandwich fold that forms a hydrophobic pocket capable of binding lauroyl (C12) and myristoyl (C14) side chains.
Consequences of a mutation in the UNC119 gene for T cell function in idiopathic CD4 lymphopenia.
Alam et al., Denver, United States. In Curr Allergy Asthma Rep, 2012
TCR activates LCK through the adaptor protein uncoordinated 119 (UNC119).
Relationships between progesterone receptor isoforms and the HER/ErbB receptors and ligands network in 299 primary breast cancers.
Bonneterre et al., Lille, France. In Int J Biol Markers, 2012
The PR isoforms positively correlated with the mRNA levels of HER/ErbB receptors and ligands associated with a more differentiated phenotype (HER3, HER4, EGF, AREG, NRG3 and NRG4) while they correlated negatively with those associated with aggressiveness (EGFR, TGFa, HB-EGF, EREG, and NRG2).
The role of neuregulin4 and HER4 in gastrointestinal malignant lymphoma.
Joh et al., Nagoya, Japan. In Mol Med Report, 2011
The recombinant neuregulin 4 induced the tyrosine phosphorylation of HER4.
Interaction of transducin with uncoordinated 119 protein (UNC119): implications for the model of transducin trafficking in rod photoreceptors.
Artemyev et al., Iowa City, United States. In J Biol Chem, 2011
Interaction of transducin with uncoordinated 119 protein (UNC119): implications for the model of transducin trafficking in rod photoreceptors.
UNC119 is required for G protein trafficking in sensory neurons.
Baehr et al., Salt Lake City, United States. In Nat Neurosci, 2011
This study demonistrated that UNC119 is a Galpha subunit cofactor essential for G protein trafficking in sensory cilia.
Uncoordinated 119 preferentially induces Th2 differentiation and promotes the development of asthma.
Alam et al., Denver, United States. In J Immunol, 2010
Unc119 has a critical role in the development of airway inflammation, mucus production, and bronchial hyperreactivity in a mouse model of experimental asthma.
UNC119 inhibits dynamin and dynamin-dependent endocytic processes.
Alam et al., Denver, United States. In Cell Signal, 2010
demonstrate a role for Unc119 in clathrin- and caveolae-based endocytosis as well as macropinocytosis. Depletion of Unc119 in fibroblasts increases FM4-64, albumin, viruses, and ligand-coated beads.
The neuregulin-I/ErbB signaling system in development and disease.
Britsch, Berlin, Germany. In Adv Anat Embryol Cell Biol, 2006
The neuregulin family of ligands has four members: NRG1, NRG2, NRG3, and NRG4.
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