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Unc-51 like kinase 1

UNC-51-Like Kinase, unc-51-like kinase 1
predicted to have similarity to C. elegans serine/threonine kinase UNC-51 [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: Atg1, mTOR, AMPK, LC3, p70
Papers on UNC-51-Like Kinase
BRAF(V600E) inhibition stimulates AMP-activated protein kinase-mediated autophagy in colorectal cancer cells.
Ishii et al., Suita, Japan. In Sci Rep, Dec 2015
The present data show AMPK-dependent cytoprotective roles of autophagy under conditions of therapeutic BRAF(V600E) inhibition, and AMPK was negatively correlated with BRAF(V600E)-dependent activation of MEK-ERK-RSK signaling and positively correlated with unc-51-like kinase 1 (ULK1), a key initiator of autophagy.
High expression levels of unc-51-like kinase 1 as a predictor of poor prognosis in colorectal cancer.
Lan et al., Guangzhou, China. In Oncol Lett, Sep 2015
Unc-51-like kinase 1 (ULK1) plays an important role in autophagy, which is widely involved in human CRC.
Modulation of autophagy signaling with resistance exercise and protein ingestion following short-term energy deficit.
Camera et al., Melbourne, Australia. In Am J Physiol Regul Integr Comp Physiol, Sep 2015
Notably, these changes were subsequent to increases in unc-51-like kinase 1(Ser757) phosphorylation (∼60%) 1 h postexercise in PRO.
DAPK2 is a novel regulator of mTORC1 activity and autophagy.
Kimchi et al., Israel. In Cell Death Differ, Mar 2015
At the molecular level, DAPK2 depletion interfered with mTORC1 inhibition caused by these two stresses, as reflected by the phosphorylation status of mTORC1 substrates, ULK1 (unc-51-like kinase 1), p70 ribosomal S6 kinase and eukaryotic initiation factor 4E-binding protein 1.
Mitophagy is required for acute cardioprotection by simvastatin.
Gottlieb et al., San Diego, United States. In Antioxid Redox Signal, 2014
RESULTS: HL-1 cardiomyocytes exposed to simvastatin for 24 h exhibited diminished protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling, increased activation of unc-51-like kinase 1, and upregulation of autophagy and mitophagy.
Autophagy activation is involved in 3,4-methylenedioxymethamphetamine ('ecstasy')--induced neurotoxicity in cultured cortical neurons.
Huang et al., Taipei, Taiwan. In Plos One, 2013
Furthermore, MDMA induced phosphorylation of AMP-activated protein kinase (AMPK) and its downstream unc-51-like kinase 1 (ULK1), suggesting the AMPK/ULK1 signaling pathway might be involved in MDMA-induced autophagy activation.
Prior starvation mitigates acute doxorubicin cardiotoxicity through restoration of autophagy in affected cardiomyocytes.
Minatoguchi et al., Gifu, Japan. In Cardiovasc Res, 2013
The activities of both AMP-activated protein kinase and the autophagy-initiating kinase unc-51-like kinase 1 (ULK1) were found to be decreased by doxorubicin, and these were restored by prior starvation.
Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks.
Stork et al., Tübingen, Germany. In Mol Cell Biol, 2012
This review focuses on the serine/threonine protein kinases AMP-activated protein kinase, mammalian target of rapamycin (mTOR), and unc-51-like kinase 1/2 (Ulk1/2), three interconnected major junctions within the autophagy regulating signaling network.
Upregulation of human autophagy-initiation kinase ULK1 by tumor suppressor p53 contributes to DNA-damage-induced cell death.
Wang et al., Dallas, United States. In Cell Death Differ, 2011
This mechanism of autophagy initiation is conserved, as unc-51-like kinase 1 (ULK1) and unc-51-like kinase 2 (ULK2) are two mammalian functional homologues of ATG1 and form similar complex with mammalian ATG13.
A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy.
Dennis et al., Cincinnati, United States. In Autophagy, 2009
Atg1 orthologs, including mammalian unc-51-like kinase 1 (ULK1), have been identified in higher eukaryotes and have been functionally linked to autophagy.
mTORC1 phosphorylates the ULK1-mAtg13-FIP200 autophagy regulatory complex.
Chan, Glasgow, United Kingdom. In Sci Signal, 2008
The complementary inhibitory mechanism in which mTORC1 phosphorylates the autophagy regulatory complex containing unc-51-like kinase 1 (ULK1), the mammalian Atg13 protein, and focal adhesion kinase interacting protein of 200 kD (FIP200) has also been elucidated.
Inhibition of methylation and changes in gene expression in relation to neural tube defects.
Blom et al., Nijmegen, Netherlands. In Birth Defects Res A Clin Mol Teratol, 2008
Of the 15 genes selected for QPCR analysis, the up-regulation of phosphoserine phosphatase (PSPH), unc-51-like kinase 1 (ULK1), and chemokine (C-X-C motif) ligand 12/stromal cell-derived factor 1 (CXCL12/SDF-1) was confirmed.
siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy.
Tooze et al., London, United Kingdom. In J Biol Chem, 2007
ULK1 knockdown inhibited rapamycin-induced autophagy consistent with a role downstream of mTOR
Identification of mouse ULK1, a novel protein kinase structurally related to C. elegans UNC-51.
Muramatsu et al., Chiba, Japan. In Biochem Biophys Res Commun, 1998
The UNC-51-Like Kinase (ULK)1 is encoded by a cDNA of 1051 amino acids with calculated MW of 113 kDa.
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