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Cytidine monophosphate

UMP-CMP kinase 2, mitochondrial UMP-CMP kinase, UMP-CMPK2, CMPK2
This gene encodes one of the enzymes in the nucleotide synthesis salvage pathway that may participate in terminal differentiation of monocytic cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012] (from NCBI)
Top mentioned proteins: MxA, CAN, ATF3, SOCS3, STAT1
Papers on UMP-CMP kinase 2
Association of the interferon signature metric with serological disease manifestations but not global activity scores in multiple cohorts of patients with SLE.
Townsend et al., San Francisco, United States. In Lupus Sci Med, 2014
RESULTS: Three genes, HERC5, EPSTI and CMPK2, correlated well with the IS (p>0.96), and composed the ISM qPCR assay.
Hepatitis E genotype 4 virus from feces of monkeys infected experimentally can be cultured in PLC/PRF/5 cells and upregulate host interferon-inducible genes.
Wang et al., Beijing, China. In J Med Virol, 2014
Four interferon-inducible genes, IFI27, IFI6, Mx1, and CMPK2, were up-regulated during HEV-infection.
Negative regulation of the interferon response by an interferon-induced long non-coding RNA.
Valadkhan et al., Cleveland, United States. In Nucleic Acids Res, 2013
This RNA, which we named lncRNA-CMPK2, was a spliced, polyadenylated nuclear transcript that was induced by IFN in diverse cell types from human and mouse.
Detection of significant pathways in osteoporosis based on graph clustering.
Xue et al., Shanghai, China. In Mol Med Report, 2012
This study provides a number of candidate genes that warrant further investigation, including DDX60, HERC5, RSAD2, SIGLEC1, CMPK2, MX1, SEPING1, EPSTI1, C9orf72, PHLDA2, PFKFB3, PLEKHG2, ANKRD28, IL1RN and RNF19B.
Sex-specific regulation of mitochondrial DNA levels: genome-wide linkage analysis to identify quantitative trait loci.
Soria et al., Barcelona, Spain. In Plos One, 2011
It was near the gene CMPK2, which encodes a mitochondrial enzyme of the salvage pathway of deoxyribonucleotide synthesis.
Long-term genome-wide blood RNA expression profiles yield novel molecular response candidates for IFN-beta-1b treatment in relapsing remitting MS.
Zettl et al., Rostock, Germany. In Pharmacogenomics, 2010
CMPK2, FCER1A, and FFAR2 appeared as hitherto unrecognized multiple sclerosis treatment-related differentially expressed genes that were consistently modulated over time.
Identification of a putative human mitochondrial thymidine monophosphate kinase associated with monocytic/macrophage terminal differentiation.
Chang et al., Taipei, Taiwan. In Genes Cells, 2008
Upregulated in monocyte/macrophage differentiating cells, suggesting coordinated regulation with the terminal differentiation program.
Human UMP-CMP kinase 2, a novel nucleoside monophosphate kinase localized in mitochondria.
Karlsson et al., Stockholm, Sweden. In J Biol Chem, 2008
a human mitochondrial UMP-CMP kinase (UMP-CMPK, cytidylate kinase; EC, designated as UMP-CMP kinase 2 (UMP-CMPK2), is identified.
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