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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Unc-51-like kinase 3

Top mentioned proteins: Csk, Lnk, CYP1A1, TOP, PMCA1
Papers on ULK3
Gene Silencing and Haploinsufficiency of Csk Increase Blood Pressure.
Oh et al., Seoul, South Korea. In Plos One, Dec 2015
METHODS AND RESULTS: CSK and ULK3 were selected as candidate genes based on eQTL analysis studies that showed the association between gene transcript levels and the lead SNP (rs1378942).
Effects of established blood pressure loci on blood pressure values and hypertension risk in an Algerian population sample.
Meirhaeghe et al., Oran, Algeria. In J Hum Hypertens, May 2015
The SNPs in CYP1A1-ULK3, HFE and SH2B3 were significantly associated with BP and/or HTN.
ULK3 regulates cytokinetic abscission by phosphorylating ESCRT-III proteins.
Martin-Serrano et al., London, United Kingdom. In Elife, 2014
In this study, we show that Unc-51-like kinase 3 (ULK3) phosphorylates and binds ESCRT-III subunits via tandem MIT domains, and thereby, delays abscission in response to lagging chromosomes, nuclear pore defects, and tension forces at the midbody.
Elevated blood pressure: Our family's fault? The genetics of essential hypertension.
Slavin et al., Honolulu, United States. In World J Cardiol, 2014
Of note, genes with multiple study references include: STK39, CYP17A1, MTHFR-NPPA, MTHFR-NPPB, ATP2B1, CSK, ZNF652, UMOD, CACNB2, PLEKHA7, SH2B3, TBX3-TBX5, ULK4, CSK-ULK3, CYP1A2, NT5C2, CYP171A, PLCD3, SH2B3, ATXN2, CACNB2, PLEKHA7, SH2B3, TBX3-TBX5, ULK4, and HFE.
NCoR controls glioblastoma tumor cell characteristics.
Hermanson et al., Stockholm, Sweden. In Neuro Oncol, 2014
chromatin immunoprecipitation sequencing approach revealed alternative mechanisms underlying the decrease in proliferation, as NCoR was enriched at promoters of genes associated with autophagy such as ULK3.
Gene expression responses of threespine stickleback to salinity: implications for salt-sensitive hypertension.
Cai et al., College Station, United States. In Front Genet, 2013
These also included genes located in the GWAS loci such as AGTRAP-PLOD1 and CYP1A1-ULK3, which contain multiple potentially causative genes contributing to HTN susceptibility that need to be prioritized for study.
Structural and logical analysis of a comprehensive hedgehog signaling pathway to identify alternative drug targets for glioma, colon and pancreatic cancer.
Sarkar et al., Pune, India. In Plos One, 2012
From our study we observed the under expressions of various oncoproteins in Hedgehog pathway while perturbing at a time the combinations of the proteins GLI1, GLI2 and SMO in Glioma; SMO, HFU, ULK3 and RAS in Colon cancer; SMO, HFU, ULK3, RAS and ERK12 in Pancreatic cancer.
Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM.
van Duijn et al., Rotterdam, Netherlands. In Mol Psychiatry, 2012
Significant evidence of association was also detected at rs382140 (P-value=3.9 × 10(-09)) near NRCAM-a gene implicated in vulnerability to addiction, and at another independent hit rs6495122 (P-value=7.1 × 10(-09))-an SNP associated with blood pressure-in the 15q24 region near the gene ULK3, in the meta-analysis of discovery and replication cohorts.
Genome-wide association uncovers shared genetic effects among personality traits and mood states.
Deary et al., Edinburgh, United Kingdom. In Am J Med Genet B Neuropsychiatr Genet, 2012
Other notable associations (P < 6.09 × 10(-6)) included SNPs in five genes for neuroticism (LCE3C, POLR3A, LMAN1L, ULK3, SCAMP2), KIAA0802 for extraversion, and NOS1 for general psychological distress.
Genetic variations in CYP17A1, CACNB2 and PLEKHA7 are associated with blood pressure and/or hypertension in She ethnic minority of China.
Chen et al., Ningde, China. In Atherosclerosis, 2011
We genotyped 7 variants in CYP17A1, PLEKHA7, CACNB2, ATP2B1, TBX3-TBX5, CSK-ULK3 and SH2B3 reported by the previous GWAs on Europeans.
Sodium arsenite dependent protein expression analysis on human embryonic carcinoma (NCCIT) cell line.
Chai et al., Ansan, South Korea. In Toxicol Lett, 2011
Long-term NaAsO(2) treatment caused marked up-regulation of B23/nucleophosmin, glucose regulated protein 78-kDa (GRP78), unc-51-like kinase 3 (ULK3), toll-like receptor 6 precursor (TLR6) and mitogen-activated protein kinase 7 isoform A (MAP3K7).
Pharmacological inhibition of the Hedgehog pathway prevents human rhabdomyosarcoma cell growth.
Setoguchi et al., Kagoshima, Japan. In Int J Oncol, 2011
Real-time PCR revealed that human rhabdomyosarcoma cell lines and biopsy specimens overexpressed the following genes: Sonic hedgehog, Indian hedgehog, Desert hedgehog, PTCH1, SMO, GLI1, GLI2 and ULK3.
Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study.
Levy et al., Jackson, United States. In Hum Mol Genet, 2011
We replicated previously reported European-American blood pressure SNPs in our AA samples (SH2B3, P= 0.009; TBX3-TBX5, P= 0.03; and CSK-ULK3, P= 0.0004).
Autophagy impairment induces premature senescence in primary human fibroblasts.
Park et al., Seoul, South Korea. In Plos One, 2010
In contrast to the lifespan extension effect in lower organisms, it has been reported that overexpression of unc-51-like kinase 3 (ULK3), the mammalian homolog of autophagy-specific gene 1 (ATG1), induces premature senescence in human fibroblasts.
Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog signaling pathway.
Kogerman et al., Tallinn, Estonia. In J Biol Chem, 2010
Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog signaling pathway.
Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway.
Osterlund et al., Tallinn, Estonia. In Exp Cell Res, 2010
serine/threonine kinase ULK3 is involved in the SHH pathway as a positive regulator of GLI proteins
Genome-wide association study of blood pressure and hypertension.
van Duijn et al., Framingham, United States. In Nat Genet, 2009
When ten CHARGE SNPs for each trait were included in a joint meta-analysis with the Global BPgen Consortium (n = 34,433), four CHARGE loci attained genome-wide significance (P < 5 × 10(-8)) for SBP (ATP2B1, CYP17A1, PLEKHA7, SH2B3), six for DBP (ATP2B1, CACNB2, CSK-ULK3, SH2B3, TBX3-TBX5, ULK4) and one for hypertension (ATP2B1).
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