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UDP glucuronosyltransferase 2 family, polypeptide B7

UGT2B7, UDP-glucuronosyltransferase 2B7
The protein encoded by this gene belongs to the UDP-glycosyltransferase (UGT) family. UGTs serve a major role in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein is localized in the microsome membrane, and has unique specificity for 3,4-catechol estrogens and estriol, suggesting that it may play an important role in regulating the level and activity of these potent estrogen metabolites. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: UDP-glucuronosyltransferase, UGT, Glucuronosyltransferase, UGT1A1, ACID
Papers on UGT2B7
Gene expression in prolactinomas: a systematic review.
Carmichael et al., Los Angeles, United States. In Pituitary, Feb 2016
Of the many genes identified, three upregulated (HMGA2, HST, SNAP25), and three downregulated (UGT2B7, Let7, miR-493) genes were selected for further analysis based on our subjective identification of strong potential targets.
Oral morphine pharmacokinetic in obesity: the role of P-glycoprotein, MRP2, MRP3, UGT2B7 and CYP3A4 jejunal contents and obesity-associated biomarkers.
Decleves et al., In Mol Pharm, Feb 2016
OBJECTIVE: To study the influence of the jejunal expression levels of P-gp, MRP2, MRP3, UGT2B7, CYP3A4, the influence of the ABCB1 c.3435C>T polymorphism and of several obesity-associated biomarkers, on oral morphine and glucuronides pharmacokinetics in a population of morbid obese subjects.
Characterization of 137 Genomic DNA Reference Materials for 28 Pharmacogenetic Genes: A GeT-RM Collaborative Project.
Kalman et al., Camden, United States. In J Mol Diagn, Jan 2016
To address this need, the Centers for Disease Control and Prevention-based Genetic Testing Reference Material Coordination Program, in collaboration with members of the pharmacogenetic testing community and the Coriell Cell Repositories, has characterized 137 genomic DNA samples for 28 genes commonly genotyped by pharmacogenetic testing assays (CYP1A1, CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4, CYP3A5, CYP4F2, DPYD, GSTM1, GSTP1, GSTT1, NAT1, NAT2, SLC15A2, SLC22A2, SLCO1B1, SLCO2B1, TPMT, UGT1A1, UGT2B7, UGT2B15, UGT2B17, and VKORC1).
The pharmacogenetics of opioid therapy in the management of postpartum pain: a systematic review.
Koren et al., Toronto, Canada. In Pharmacogenomics, Jan 2016
This systematic review reveals that CYP2D6, OPRM1 A118G, UGT2B7 C802T and ABCB1 G2677AT may contribute to postpartum analgesia or adverse events.
Effects of UGT2B7 genetic polymorphisms on serum concentrations of valproic acid in Chinese epileptic children comedicated with lamotrigine.
Guo et al., Changchun, China. In Ther Drug Monit, Jan 2016
VPA is a substrate of uridine diphosphate glucuronosyltransferase 2B7 (UGT2B7).
Albumin's Influence on Carprofen Enantiomers-Hymecromone Interaction.
Wang et al., Xi'an, China. In Chirality, Jan 2016
In contrast, no significant difference was observed for the inhibition of (S)-carprofen on UGT2B7 activity in the absence or presence of 0.5% BSA in the incubation system.
Efavirenz pharmacogenetics in a cohort of Italian patients.
D'Avolio et al., Torino, Italy. In Int J Antimicrob Agents, Jan 2016
Whole blood was used to identify SNPs in ABCB1, MRP2, CYP2B6, CYP2A6, UGT2B7, NR1I2 (PXR), NR1I3 (CAR) and HNF4α by real-time PCR.
Osteoblasts promote castration-resistant prostate cancer by altering intratumoral steroidogenesis.
Welén et al., Göteborg, Sweden. In Mol Cell Endocrinol, Dec 2015
Osteoblast-stimulated LNCaP-19 cells displayed an increased expression of genes encoding for steroidogenic enzymes (CYP11A1, HSD3B1, and AKR1C3), estrogen signaling-related genes (CYP19A1, and ESR2), and genes for DHT-inactivating enzymes (UGT2B7, UGT2B15, and UGT2B17).
Pharmacogenetics of drug-metabolizing enzymes in US Hispanics.
Ruaño et al., In Drug Metabol Personal Ther, Jun 2015
A higher prevalence of CYP2C9*3, CYP2C19*4, and UGT2B7 IVS1+985 A>G was observed in US Hispanic vs. non-Hispanic populations.
Pharmacogenetics of CYP2B6, CYP2A6 and UGT2B7 in HIV treatment in African populations: focus on efavirenz and nevirapine.
Pepper et al., Pretoria, South Africa. In Drug Metab Rev, May 2015
This review aims to investigate ethnic variation of CYP2B6, CYP2A6 and UGT2B7, and to understand the pharmacogenetic relevance when comparing frequencies in African populations to other populations worldwide.
An Expanded Analysis of Pharmacogenetics Determinants of Efavirenz Response that Includes 3'-UTR Single Nucleotide Polymorphisms among Black South African HIV/AIDS Patients.
Dandara et al., Cape Town, South Africa. In Front Genet, 2014
The drug metabolizing enzyme (DME), CYP2B6, is primarily responsible for EFV metabolism with minor contributions by CYP1A2, CYP2A6, CYP3A4, CYP3A5, and UGT2B7.
In Vitro Metabolic Pathways of the New Anti-Diabetic Drug Evogliptin in Human Liver Preparations.
Lee et al., Puch'ŏn, South Korea. In Molecules, 2014
Glucuronidation of 4(S)-hydroxy-evogliptin (M2) to 4(S)-hydroxyevogliptin glucuronide (M4) was catalyzed by the enzymes UGT2B4 and UGT2B7.
Effect of an ethanol extract of Descurainia sophia seeds on Phase I and II drug metabolizing enzymes and P-glycoprotein activity in vitro.
Kim et al., Taejŏn, South Korea. In Bmc Complement Altern Med, 2014
Other Phase I (CYP2C8, CYP2D6, and CYP3A4) and Phase II (UGT1A1 and UGT2B7) enzymes as well as P-gp were weakly or negligibly affected by EEDS with concentrations up to 500 μg/mL.
Effects of mitragynine and 7-hydroxymitragynine (the alkaloids of Mitragyna speciosa Korth) on 4-methylumbelliferone glucuronidation in rat and human liver microsomes and recombinant human uridine 5'-diphospho-glucuronosyltransferase isoforms.
Ismail et al., George Town, Malaysia. In Pharmacognosy Res, 2014
OBJECTIVE: The objective was to evaluate the inhibitory potentials of mitragynine, 7-hydroxymitragynine, ketamine and buprenorphine, respectively on 4-methylumbelliferone (4-MU) glucuronidation in rat liver microsomes, human liver microsomes and recombinant human UGT1A1 and UGT2B7 isoforms.
Genetic basis of drug-induced liver injury: present and future.
Aithal et al., Newcastle upon Tyne, United Kingdom. In Semin Liver Dis, 2014
Though the associations with non-HLA genes have been less well replicated than the HLA associations, there is increasing evidence that drug metabolism genes such as NAT2 and UGT2B7 contribute to some forms of DILI.
Methadone inhibits CYP2D6 and UGT2B7/2B4 in vivo: a study using codeine in methadone- and buprenorphine-maintained subjects.
Somogyi et al., Adelaide, Australia. In Br J Clin Pharmacol, 2012
Methadone inhibits CYP2D6 and UGT2B7/2B4 in vivo
Human UDP-glucuronosyltransferase isoforms involved in haloperidol glucuronidation and quantitative estimation of their contribution.
Yokoi et al., Kanazawa, Japan. In Drug Metab Dispos, 2012
Data suggest that UGT2B7 is the predominant activity in liver microsomes for haloperidol O-glucuronidation (in both human and rat).
Association of polymorphisms in EPHX1, UGT2B7, ABCB1, ABCC2, SCN1A and SCN2A genes with carbamazepine therapy optimization.
Liou et al., Taiwan. In Pharmacogenomics, 2012
the present study revealed that EPHX1, UGT2B7 and SCN1A genetic polymorphisms simultaneously modulated the CBZ maintenance doses and CDRs(concentration-dose ratios)
Bovine serum albumin decreases Km values of human UDP-glucuronosyltransferases 1A9 and 2B7 and increases Vmax values of UGT1A9.
Finel et al., Helsinki, Finland. In Drug Metab Dispos, 2011
In the case of UGT2B7, our results agree with the previously described effect of BSA, namely lowering the K(m) value without a large effect on the enzyme's V(max) value.
Transcriptional diversity at the UGT2B7 locus is dictated by extensive pre-mRNA splicing mechanisms that give rise to multiple mRNA splice variants.
Guillemette et al., Québec, Canada. In Pharmacogenet Genomics, 2011
these findings point toward a significant variability in structure, abundance, and tissue-specific UGT2B7 transcriptome, in addition to novel functions for UGT2B7-derived proteins
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