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UDP glucuronosyltransferase 2 family, polypeptide B4

UGT2B4, UGT2B11, UDP-glucuronosyltransferase 2B4, HLUG25
Top mentioned proteins: UDP-glucuronosyltransferase, UGT, UGT2B7, Glucuronosyltransferase, UGT1A1
Papers on UGT2B4
Human UDP-glucuronosyltransferase (UGT) 2B10: Validation of cotinine as a selective probe substrate, inhibition by UGT enzyme selective inhibitors and antidepressant and antipsychotic drugs, and structural determinants of enzyme inhibition.
Miners et al., In Drug Metab Dispos, Jan 2016
Of the UGT enzyme selective inhibitors employed for reaction phenotyping, only the UGT2B4/7 inhibitor fluconazole reduced recombinant UGT2B10 activity to an appreciable extent.
Esophageal Cancer Epigenomics and Integrome Analysis of Genome-Wide Methylation and Expression in High Risk Northeast Indian Population.
Saxena et al., New Delhi, India. In Omics, Nov 2015
These included four genes (PTK2, RND1, RND3, and UBL3) with promoter hypermethylation and downregulation, and 19 genes (SEMG2, CD97, CTNND2, CADM3, OMD, NEFM, FBN2, CTNNB1, DLX6, UGT2B4, CCDC80, PZP, SERPINA4, TNFSF13B, NPC1, COL1A1, TAC3, BMP8A, and IL22RA2) with promoter hypomethylation and upregulation.
Metabolism of kurarinone by human liver microsomes and its effect on cytotoxicity.
Cheng et al., Shanghai, China. In Pharm Biol, Nov 2015
M4 formation was catalyzed by UGT1A1, UGT2B4, and UGT2B7.
Clinical Pharmacokinetic, Pharmacodynamic, and Drug-Drug Interaction Profile of Canagliflozin, a Sodium-Glucose Co-transporter 2 Inhibitor.
Polidori et al., United States. In Clin Pharmacokinet, Oct 2015
Canagliflozin is glucuronidated into two inactive metabolites, M7 and M5 by uridine diphosphate-glucuronosyltransferase (UGT) 1A9 and UGT2B4, respectively.
Histopathology of melanosis coli and determination of its associated genes by comparative analysis of expression microarrays.
Li et al., Chengdu, China. In Mol Med Report, Oct 2015
Expression microarray analysis revealed that the significantly downregulated genes were CYP3A4, CYP3A7, UGT2B11 and UGT2B15 in melanosis coli.
Multiplexed Targeted Quantitative Proteomics Predicts Hepatic Glucuronidation Potential.
Guillemette et al., Québec, Canada. In Drug Metab Dispos, Sep 2015
UGT2B7 is the most abundant UGT in our collection of livers, expressed at 69 pmol/mg microsomal proteins, whereas UGT1A1, UGT1A4, UGT2B4, and UGT2B15 are similarly abundant, averaging 30-34 pmol/mg proteins.
Upregulation of UGT2B4 Expression by 3'-Phosphoadenosine-5'-Phosphosulfate Synthase Knockdown: Implications for Coordinated Control of Bile Acid Conjugation.
Runge-Morris et al., Detroit, United States. In Drug Metab Dispos, Jul 2015
During cholestasis, the bile acid-conjugating enzymes, SULT2A1 and UGT2B4, work in concert to prevent the accumulation of toxic bile acids.
Polymorphisms in UGT2B4 and susceptibility to pancreatic cancer.
Qi et al., Beijing, China. In Int J Clin Exp Med, 2014
As an important enzyme in the conjugation phase of drug clearance, UGT2B4 helps metabolize various endogenous and exogenous substances, and polymorphisms in the corresponding gene can influence enzyme activity.
Human induced hepatic lineage-oriented stem cells: autonomous specification of human iPS cells toward hepatocyte-like cells without any exogenous differentiation factors.
Ochiya et al., Tokyo, Japan. In Plos One, 2014
After 12 days of this culture, the differentiated cells significantly enhanced gene expression of serum hepatic proteins (ALB, SERPINA1, TTR, TF, FABP1, FGG, AGT, RBP4, and AHSG), conjugating enzymes (UGT2B4, UGT2B7, UGT2B10, GSTA2, and GSTA5), transporters (SULT2A1, SLC13A5, and SLCO2B1), and urea cycle-related enzymes (ARG1 and CPS1).
In Vitro Metabolic Pathways of the New Anti-Diabetic Drug Evogliptin in Human Liver Preparations.
Lee et al., Puch'ŏn, South Korea. In Molecules, 2014
Glucuronidation of 4(S)-hydroxy-evogliptin (M2) to 4(S)-hydroxyevogliptin glucuronide (M4) was catalyzed by the enzymes UGT2B4 and UGT2B7.
Human UDP-Glucuronosyltransferases: Effects of altered expression in breast and pancreatic cancer cell lines.
Radominska-Pandya et al., In Cancer Biol Ther, 2014
Expression plasmids for UGT2B isoforms known to glucuronidate cellular lipids, UGT2B4, 2B7, and 2B15 were transfected into MCF-7 and Panc-1 cells, and the cytotoxic effects of these enzymes were analyzed using trypan blue exclusion, annexin V/PI staining, TUNEL assays, and caspase-3 immunohistochemistry.
Human UDP-glucuronosyltransferases: feedback loops between substrates and ligands of their transcription factors.
Bock, Tübingen, Germany. In Biochem Pharmacol, 2012
(ii) Hepatotoxic lithocholic acid (LCA) is oxidized to hyodeoxycholic acid, the latter conjugated by UGT2B4 and UGT2B7.
High enzyme activity UGT1A1 or low activity UGT1A8 and UGT2B4 genotypes increase esophageal cancer risk.
Peters et al., Nijmegen, Netherlands. In Int J Oncol, 2012
The UGT1A8 and UGT2B4 genotypes associated with decreased predicted enzyme activities, were significantly associated with an increased risk of esophageal squamous cell carcinoma.
Methadone inhibits CYP2D6 and UGT2B7/2B4 in vivo: a study using codeine in methadone- and buprenorphine-maintained subjects.
Somogyi et al., Adelaide, Australia. In Br J Clin Pharmacol, 2012
Methadone inhibits CYP2D6 and UGT2B7/2B4 in vivo
A signature of balancing selection in the region upstream to the human UGT2B4 gene and implications for breast cancer risk.
Di Rienzo et al., Chicago, United States. In Hum Genet, 2011
The variation pattern upstream UGT2B4 is highly unusual and may be the result of balancing selection.
Functions and transcriptional regulation of adult human hepatic UDP-glucuronosyl-transferases (UGTs): mechanisms responsible for interindividual variation of UGT levels.
Bock, Tübingen, Germany. In Biochem Pharmacol, 2010
Ten out of 19 UDP-glucuronosyltransferases (UGTs) are substantially expressed in adult human liver (>1% of total UGTs); 5 UGT1 isoforms (UGT1A1, 1A3, 1A4, 1A6 and 1A9) and 5 UGT2 family members (UGT2B4, 2B7, 2B10, 2B15 and 2B17) (Izukawa et al. [11]).
Extensive splicing of transcripts encoding the bile acid-conjugating enzyme UGT2B4 modulates glucuronidation.
Guillemette et al., Québec, Canada. In Pharmacogenet Genomics, 2010
Extensive splicing of transcripts of the bile acid-conjugating enzyme UGT2B4 modulates glucuronidation.
Substrate specificity of the human UDP-glucuronosyltransferase UGT2B4 and UGT2B7. Identification of a critical aromatic amino acid residue at position 33.
Ouzzine et al., Vandœuvre-lès-Nancy, France. In Febs J, 2007
Results strongly indicated that the presence of an aromatic residue at position 33 is important for the activity and specificity of UGTB4.
FXR: a target for cholestatic syndromes?
Boyer et al., New Haven, United States. In Expert Opin Ther Targets, 2006
The nuclear farnesoid X receptor (FXR) plays a pivotal role in maintaining bile acid homeostasis by regulating key genes involved in bile acid synthesis, metabolism and transport, including CYP7A1, UGT2B4, BSEP, MDR3, MRP2, ASBT, I-BABP, NTCP and OSTalpha-OSTbeta in humans.
Polymorphism of UDP-glucuronosyltransferase and drug metabolism.
Takeuchi et al., Ōtsu, Japan. In Curr Drug Metab, 2005
Recent studies also revealed a widespread presence of diverse polymorphisms in other isoforms of UGT1 as well as the UGT2 family, including UGT1A6, UGTG1A7, UGT1A8, UGT1A10, UGT2B4, UGT2B7 and UGT2B15.
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