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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Solute carrier family 25, member 27

Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. Transcripts of this gene are only detected in brain tissue and are specifically modulated by various environmental conditions. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011] (from NCBI)
Top mentioned proteins: UCP1, UCP2, ACID, CAN, Ros
Papers on UCP4
Mast Cells Release Chemokine CCL2 in Response to Parkinsonian Toxin 1-Methyl-4-Phenyl-Pyridinium (MPP(+)).
Zaheer et al., Iowa City, United States. In Neurochem Res, Jan 2016
Uncoupling protein 4 (UCP4) which is implicated in neurodegenerative diseases including PD was detected in BMMCs by immunocytochemistry.
Activation of Mitochondrial Uncoupling Protein 4 and ATP-Sensitive Potassium Channel Cumulatively Decreases Superoxide Production in Insect Mitochondria.
Jarmuszkiewicz et al., Poznań, Poland. In Protein Pept Lett, Dec 2015
It has been evidenced that mitochondrial uncoupling protein 4 (UCP4) and ATP-regulated potassium channel (mKATP channel) of insect Gromphadorhina coqereliana mitochondria decrease superoxide anion production.
Superresolution microscopy reveals spatial separation of UCP4 and F0F1-ATP synthase in neuronal mitochondria.
Pohl et al., Vienna, Austria. In Proc Natl Acad Sci U S A, Feb 2015
Here, we used the superresolution technique dSTORM (direct stochastic optical reconstruction microscopy) to visualize several mitochondrial proteins in primary mouse neurons and test the hypothesis that uncoupling protein 4 (UCP4) and F0F1-ATP synthase are spatially separated to eliminate competition for the proton motive force.
A biophysical study on molecular physiology of the uncoupling proteins of the central nervous system.
Jelokhani-Niaraki et al., Guelph, Canada. In Biosci Rep, 2014
It has been proposed that the three neuronal human UCPs (UCP2, UCP4 and UCP5) in the central nervous system (CNS) play significant roles in reducing cellular oxidative stress.
Control of mitochondrial pH by uncoupling protein 4 in astrocytes promotes neuronal survival.
Lengacher et al., Lausanne, Switzerland. In J Biol Chem, 2014
The main UCP isoforms expressed in the brain are UCP2, UCP4, and UCP5.
Identification of uncoupling protein 4 from the blood-sucking insect Rhodnius prolixus and its possible role on protection against oxidative stress.
Meyer-Fernandes et al., Rio de Janeiro, Brazil. In Insect Biochem Mol Biol, 2014
The increase in UCP4 expression is coincident with the decrease in hydrogen peroxide (H2O2) generation by midgut cells.
Uncoupling protein 2 and 4 expression pattern during stem cell differentiation provides new insight into their putative function.
Pohl et al., Vienna, Austria. In Plos One, 2013
In contrast, UCP4 is simultaneously up-regulated together with typical neuronal marker proteins TUJ-1 and NeuN during mESC differentiation in vitro as well as during murine brain development in vivo.
UCP4 expression changes in larval and pupal fat bodies of the beetle Zophobas atratus under adipokinetic hormone treatment.
Jarmuszkiewicz et al., Poznań, Poland. In Comp Biochem Physiol A Mol Integr Physiol, 2013
We investigated the influence of adipokinetic hormone (AKH), an insect neurohormone, on uncoupling protein 4 (ZaUCP4) expression and activity in larval and pupal fat body mitochondria of the beetle Zophobas atratus in relation to intermediary metabolism.
Evidence for involvement of uncoupling proteins in cerebral mitochondrial oxidative phosphorylation deficiency of rats exposed to 5,000 m high altitude.
Liu et al., Chongqing, China. In Neurochem Res, 2013
Proton leak kinetics curves demonstrated an increase in proton leak; GTP binding assay pointed out that total cerebral UCPs activity significantly increased; Q-PCR and western blot showed upregulated expression of UCP4 and UCP5.
Toward understanding the mechanism of ion transport activity of neuronal uncoupling proteins UCP2, UCP4, and UCP5.
Jelokhani-Niaraki et al., Waterloo, Canada. In Biochemistry, 2012
Neuronal UCP4 exhibits transmembrane chloride transport activity.
Uncoupling protein-4 (UCP4) increases ATP supply by interacting with mitochondrial Complex II in neuroblastoma cells.
Ho et al., Hong Kong, Hong Kong. In Plos One, 2011
Findings show how UCP4 overexpression increases ATP synthesis by specifically interacting with Complex II.
Role of mitochondrial uncoupling protein 4 in rat inner ear.
Pohl et al., Vienna, Austria. In Mol Cell Neurosci, 2011
Data demonstrate that UCP4 expression is differently regulated during postnatal stages and is region-specific, and may play an important role in functional maturation of the rat inner ear.
Mitochondrial UCP4 and bcl-2 expression in imprints of breast carcinomas: relationship with DNA ploidy and classical prognostic factors.
Athanassiadou et al., Athens, Greece. In Pathol Res Pract, 2011
UCP4 expression correlated with lymph node metastases, positive estrogen/progesterone receptor expression, and positivity for p53 and Ki-67 in breast carcinomas.
UCP4 overexpression improves fatty acid oxidation and insulin sensitivity in L6 myocytes.
Guo et al., Nanjing, China. In J Bioenerg Biomembr, 2011
UCP4 overexpression reduced the insulin sensitivity and mitochondrial fatty acid oxidation of L6 myocytes.
Oxidant stress evoked by pacemaking in dopaminergic neurons is attenuated by DJ-1.
Surmeier et al., Chicago, United States. In Nature, 2011
Knocking out DJ-1 (also known as PARK7 in humans and Park7 in mice), which is a gene associated with an early-onset form of Parkinson's disease, downregulated the expression of two uncoupling proteins (UCP4 (SLC25A27) and UCP5 (SLC25A14)), compromised calcium-induced uncoupling and increased oxidation of matrix proteins specifically in SNc dopaminergic neurons.
The polymorphisms of UCP2 and UCP3 genes associated with fat metabolism, obesity and diabetes.
Jois et al., Kunming, China. In Obes Rev, 2009
In mammals, more than five family members have been identified, including UCP1, UCP2, UCP3, UCP4 (or BMCP1/UCP5) and UCP5.
Mitochondrial uncoupling proteins--what is their physiological role?
Echtay, Tripoli, Lebanon. In Free Radic Biol Med, 2007
Beside, available scientific data on UCP4 and UCP5/BMCP1 will be reviewed.
Mitochondrial uncoupling proteins in the CNS: in support of function and survival.
Horvath et al., New Haven, United States. In Nat Rev Neurosci, 2005
Unlike UCP1, these proteins (UCP2, UCP4 and BMCP1/UCP5) are not constitutive uncouplers and are not crucial for non-shivering thermogenesis.
Mitochondrial uncoupling proteins in the central nervous system.
Dugan et al., Saint Louis, United States. In Antioxid Redox Signal, 2005
Expression of mRNA for three other UCP isoforms, UCP2, UCP4, and BMCP1/UCP5, has been found at high levels in brain.
[UCP-3: regulation of genic expression on skeletal muscle and possible role on body weight control].
Garcia Júnior et al., Presidente Prudente, Brazil. In Arq Bras Endocrinol Metabol, 2004
UCP-1, the first UCP to be described, is found exclusively in brown adipose tissue, UCP-2 in several tissues, UCP-3 in human skeletal muscle and rat brown adipose tissue and skeletal muscle, whereas UCP-4 is expressed in the brain.
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