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UBX domain protein 4

UBXD2, Erasin
UBXD2 is an integral membrane protein of the endoplasmic reticulum (ER) that binds valosin-containing protein (VCP; MIM 601023) and promotes ER-associated protein degradation (ERAD) (Liang et al., 2006 [PubMed 16968747]).[supplied by OMIM, Mar 2008] (from NCBI)
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Top mentioned proteins: V1a, T3D, FGF18, TGF-beta type I receptor, p97
Papers on UBXD2
Ubiquilin and p97/VCP bind erasin, forming a complex involved in ERAD.
Monteiro et al., Baltimore, United States. In J Cell Biol, 2009
Knockdown of erasin, a platform for p97/VCP and ubiquilin binding, or knockdown of ubiquilin in human cells slowed degradation of two classical endoplasmic reticulum-associated protein degradation substrates.
Adjusting for HLA-DRbeta1 in a genome-wide association analysis of rheumatoid arthritis and related biomarkers.
Andrade et al., New York City, United States. In Bmc Proc, 2008
RESULTS: The initial genome-wide association analysis using all cases and controls provides substantial evidence of an association on chromosomes 9 and 2 within the immune system-related gene UBXD2.
Promoter analysis of epigenetically controlled genes in bladder cancer.
Höglund et al., Lund, Sweden. In Genes Chromosomes Cancer, 2008
The genes UBXD2, AQP11, and TIMP1 showed particular patchy methylation patterns.
Characterization of erasin (UBXD2): a new ER protein that promotes ER-associated protein degradation.
Monteiro et al., Baltimore, United States. In J Cell Sci, 2006
Erasin/UBXD2 may be involved in endoplasmic-reticulum-associated protein degradation and in Alzheimer's disease.
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