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Ubiquitin protein ligase E3 component n-recognin 2

This gene encodes an E3 ubiquitin ligase of the N-end rule proteolytic pathway that targets proteins with destabilizing N-terminal residues for polyubiquitylation and proteasome-mediated degradation. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: Ubiquitin, UBR1, ACID, CAN, V1a
Papers using UBR2 antibodies
Using antibodies: A laboratory manual.
Orban Laszlo, In PLoS ONE, 1997
... Generation of anti-Tex19.1 and anti-Ubr2 polyclonal antibodyThe entire mouse Tex19.1 coding region was cloned into the pQE30 vector (QIAGEN).
Papers on UBR2
Excess of rare variants in genes that are key epigenetic regulators of spermatogenesis in the patients with non-obstructive azoospermia.
Gui et al., Shenzhen, China. In Sci Rep, 2014
We found a significant excess of rare, non-silent variants in genes that are key epigenetic regulators of spermatogenesis, such as BRWD1, DNMT1, DNMT3B, RNF17, UBR2, USP1 and USP26, in NOA patients (P = 5.5 × 10(-7)), corresponding to a carrier frequency of 22.5% of patients and 13.7% of controls (P = 1.4 × 10(-5)).
The anti-apoptotic form of tyrosine kinase Lyn that is generated by proteolysis is degraded by the N-end rule pathway.
Fahlman et al., Edmonton, Canada. In Oncotarget, 2014
Additionally we established that LynΔN degradation could be inhibited by inhibiting either the proteasome or knocking down the UBR1 and UBR2 ubiquitin E3 ligases.
The Ubr2 gene is expressed in skeletal muscle atrophying as a result of hind limb suspension, but not Merg1a expression alone.
Pond et al., West Lafayette, United States. In Eur J Transl Myol, 2014
Because the UBR2 E3 ligase is known to participate in SKM atrophy, we have investigated the effect of Merg1a expression and hind limb suspension on Ubr2 expression.
The role of histone ubiquitination during spermatogenesis.
Xu et al., Chengdu, China. In Biomed Res Int, 2013
Using Huwe1, UBR2, and RNF8 as examples, we emphasized the diverse functions for each enzyme and the broad involvement of these enzymes in every stage, from spermatogonia differentiation and meiotic division to spermiogenesis; thus histone ubiquitin ligases represent a class of enzymes, which play important roles in spermatogenesis through targeting histone for ubiquitination and therefore are involved in transcription regulation, epigenetic modification, and other processes essential for normal gametes formation.
Genome-wide identification of FoxO-dependent gene networks in skeletal muscle during C26 cancer cachexia.
Judge et al., Gainesville, United States. In Bmc Cancer, 2013
We validated these findings in limb muscles and the diaphragm through qRT-PCR, and further demonstrate that FoxO1 and/or FoxO3a are sufficient to increase Stat3, Fos, Cebpb, and the C/EBPβ target gene, Ubr2.
PINK1 is degraded through the N-end rule pathway.
Youle et al., Bethesda, United States. In Autophagy, 2013
Here, we show that, under steady-state conditions, endogenous PINK1 is constitutively and rapidly degraded by E3 ubiquitin ligases UBR1, UBR2 and UBR4 through the N-end rule pathway.
Signaling mechanism of tumor cell-induced up-regulation of E3 ubiquitin ligase UBR2.
Li et al., Houston, United States. In Faseb J, 2013
UBR2 (aka E3α-II) is the only known E3 ubiquitin ligase of the N-end rule pathway that is up-regulated by cachectic stimuli including proinflammatory cytokines and tumors.
UBR box N-recognin-4 (UBR4), an N-recognin of the N-end rule pathway, and its role in yolk sac vascular development and autophagy.
Kwon et al., Pittsburgh, United States. In Proc Natl Acad Sci U S A, 2013
Our previous studies identified the mammalian N-recognin family consisting of UBR1/E3α, UBR2, UBR4/p600, and UBR5, which recognize destabilizing N-terminal residues through the UBR box.
Genome-wide association studies for growth and meat production traits in sheep.
Du et al., Beijing, China. In Plos One, 2012
GRM1, POL, MBD5, UBR2, RPL7 and SMC2 were thought to be the important candidate genes affecting post-weaning gain too.
The Mub1/Ubr2 ubiquitin ligase complex regulates the conserved Dsn1 kinetochore protein.
Biggins et al., Seattle, United States. In Plos Genet, 2012
We find that the Mub1/Ubr2 ubiquitin ligase complex associates with kinetochore particles through the CENP-C(Mif2) protein.
The N-end rule and retroviral infection: no effect on integrase.
Somia et al., Minneapolis, United States. In Virol J, 2012
We have previously shown that the inactivation of three of these N-recognins, namely UBR1, UBR2 and UBR4 in mouse embryonic fibroblasts (MEFs) leads to increased stability of ectopically expressed HIV-1 integrase.
A network of ubiquitin ligases is important for the dynamics of misfolded protein aggregates in yeast.
Caplan et al., New York City, United States. In J Biol Chem, 2012
Data show that ubiquitin-protein ligases Ubr1 and Ubr2 have opposing roles in Ste11DeltaNK444R-GFP aggregation.
UBR2 of the N-end rule pathway is required for chromosome stability via histone ubiquitylation in spermatocytes and somatic cells.
Kwon et al., Pittsburgh, United States. In Plos One, 2011
The RING E3 ligases UBR2 and UBR1 are major N-recognins that share size (200 kDa), conserved domains and substrate specificities to N-degrons.
Single nucleotide polymorphism in the UBR2 gene may be a genetic risk factor for Japanese patients with azoospermia by meiotic arrest.
Sengoku et al., Asahikawa, Japan. In J Assist Reprod Genet, 2011
The c.1,066A>T variant in the UBR2 gene is associated with increased susceptibility to azoospermia caused by meiotic arrest.
Ubr1 and Ubr2 function in a quality control pathway for degradation of unfolded cytosolic proteins.
Caplan et al., New York City, United States. In Mol Biol Cell, 2010
Data suggest that Ubr1 and Ubr2 represent E3 components of a novel quality control pathway for proteins synthesized on cytosolic ribosomes.
UBR2 mediates transcriptional silencing during spermatogenesis via histone ubiquitination.
Kwon et al., Pittsburgh, United States. In Proc Natl Acad Sci U S A, 2010
insufficiency in UBR2-dependent histone ubiquitination triggers a pachytene checkpoint system, providing a new insight into chromatin remodeling and gene expression regulation
The ubiquitin ligase Ubr2, a recognition E3 component of the N-end rule pathway, stabilizes Tex19.1 during spermatogenesis.
Wang et al., Philadelphia, United States. In Plos One, 2009
Results suggest that the binding of Ubr2 to Tex19.1 metabolically stabilizes Tex19.1 during spermatogenesis, revealing a new function for Ubr2 outside the conventional N-end rule pathway.
Identification of a novel antibody associated with autoimmune pancreatitis.
Puccetti et al., Verona, Italy. In N Engl J Med, 2009
The peptide showed homology with an amino acid sequence of plasminogen-binding protein (PBP) of Helicobacter pylori and with ubiquitin-protein ligase E3 component n-recognin 2 (UBR2), an enzyme highly expressed in acinar cells of the pancreas.
Biting the hand that feeds: Rpn4-dependent feedback regulation of proteasome function.
Marques et al., Köln, Germany. In Biochim Biophys Acta, 2007
Acta (in press), doi:10.1016/j.bbamcr.2007.04.012] now revealed another level of complexity by showing that phosphorylation of a specific serine residue in Rpn4 is required for its efficient targeting by the Ubr2 ubiquitin ligase.
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