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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Ubiquitin specific peptidase 8

Top mentioned proteins: Ubiquitin, EGFR, AMSH, V1a, CAN
Papers on UBPY
The USP8 mutational status may predict drug susceptibility in corticotroph adenomas of Cushing's disease.
Yamada et al., Tokyo, Japan. In Eur J Endocrinol, Feb 2016
CONTEXT: Somatic mutations in the ubiquitin-specific peptidase USP8 gene were recently detected in one- to two-third(s) of corticotroph adenomas of Cushing's disease (CD).
Genetics of Cushing's disease: an update.
Reincke et al., München, Germany. In J Endocrinol Invest, Jan 2016
Using whole-exome sequencing, recurrent mutations have been reported in the gene coding for the ubiquitin-specific protease 8 (USP8), a protein with deubiquitinase (DUB) activity that modulates the lysosomal turnover of the EGF receptor (EGFR) and other membrane proteins.
VEGFR2 Trafficking, Signaling and Proteolysis is Regulated by the Ubiquitin Isopeptidase USP8.
Ponnambalam et al., Leeds, United Kingdom. In Traffic, Jan 2016
In this study, the de-ubiquitinating enzyme, USP8, is shown to regulate VEGFR2 trafficking, de-ubiquitination, proteolysis and signal transduction.
Landscape of somatic mutations in sporadic GH-secreting pituitary adenomas.
Fassnacht et al., Milano, Italy. In Eur J Endocrinol, Jan 2016
Recently, mutations affecting the USP8 and PRKACA gene have been reported in ACTH-secreting pituitary adenomas and cortisol-secreting adrenocortical adenomas, respectively.
USP8: a novel therapeutic target for Cushing's disease.
Sun et al., Shanghai, China. In Endocrine, Nov 2015
Recently, the recurrent activating mutations in the gene encoding ubiquitin-specific protease 8 (USP8) in CD have been independently reported by two teams.
A Small Molecule That Switches a Ubiquitin Ligase From a Processive to a Distributive Enzymatic Mechanism.
Statsyuk et al., Evanston, United States. In J Am Chem Soc, Nov 2015
Importantly, our study shows that processive Nedd4-1, but not the distributive Nedd4-1:inhibitor complex, is able to synthesize polyubiquitin chains on the substrate in the presence of the deubiquitinating enzyme USP8.
Decoding the genetic basis of Cushing's disease: USP8 in the spotlight.
Komada et al., Tokyo, Japan. In Eur J Endocrinol, Oct 2015
Recently, a somatic mutational hotspot was found in up to half of corticotrophinomas in the USP8 gene that encodes a protein that impairs the downregulation of the epidermal growth factor receptor (EGFR) and enables its constitutive signaling.
The New Molecular Landscape of Cushing's Disease.
Allolio et al., Würzburg, Germany. In Trends Endocrinol Metab, Oct 2015
Most recently, mutations in the gene of ubiquitin-specific peptidase 8 (USP8) increasing its deubiquination activity were discovered in a high percentage of corticotroph adenomas.
The Myopic-Ubpy-Hrs nexus enables endosomal recycling of Frizzled.
Verheyen et al., Canada. In Mol Biol Cell, Oct 2015
Mop aids in the maintenance of Ubpy, which deubiquitinates (and thus stabilizes) Hrs.
The ubiquitin-specific protease USP8 is critical for the development and homeostasis of T cells.
Knobeloch et al., Freiburg, Germany. In Nat Immunol, Sep 2015
Here we identified the ubiquitin-specific protease USP8 as a regulatory component of the T cell antigen receptor (TCR) signalosome that interacted with the adaptor Gads and the regulatory molecule 14-3-3β.
The diagnostic value of tumor markers in bronchoalveolar lavage fluid for the peripheral pulmonary carcinoma.
Wu et al., Chongqing, China. In Clin Respir J, Sep 2015
BACKGROUND: To investigate the value of Ubiquitin specific peptidase 8 (USP8), Chitinase 3-like 1 (YKL40), Heat shock protein 90a (HSP90α), glutathione S-transferase P1 (GSTP1), carcinoembryonic antigen (CEA), neuron specific enolase (NSE) and cytokeratin fragment antiogen 21-1 (CYFRA21-1) in bronchoalveolar lavage fluid (BALF) and serum for diagnosis in patients with peripheral lung cancer.
The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications.
Fon et al., Montréal, Canada. In Genes Dev, Jun 2015
Moreover, these modifications are reversible and can be disassembled by deubiquitinating enzymes (DUBs), including Ub-specific protease 8 (USP8), USP15, and USP30.
Mutations in the deubiquitinase gene USP8 cause Cushing's disease.
Komada et al., München, Germany. In Nat Genet, 2015
We found somatic mutations in the USP8 deubiquitinase gene in 4 of 10 adenomas.
The Deubiquitinating Enzyme UBPY Is Required for Lysosomal Biogenesis and Productive Autophagy in Drosophila.
Taillebourg et al., Grenoble, France. In Plos One, 2014
This screen identified Uch-L3, Usp45, Usp12 and Ubpy.
The UBC Domain Is Required for BRUCE to Promote BRIT1/MCPH1 Function in DSB Signaling and Repair Post Formation of BRUCE-USP8-BRIT1 Complex.
Du et al., Cincinnati, United States. In Plos One, 2014
It acts as a scaffold to tether USP8 and BRIT1, together they form a nuclear BRUCE-USP8-BRIT1 complex, where BRUCE holds K63-ubiquitinated BRIT1 from access to DSB in unstressed cells.
USP8 promotes smoothened signaling by preventing its ubiquitination and changing its subcellular localization.
Jia et al., Lexington, United States. In Plos Biol, 2012
USP8 is a positive regulator in Hh signaling by down-regulating Smo ubiquitination and thereby mediating Smo intracellular trafficking.
Regulation of endocytic sorting by ESCRT-DUB-mediated deubiquitination.
Nash et al., Chicago, United States. In Cell Biochem Biophys, 2011
Studies indicate that USP8/Ubpy and AMSH interact with ESCRT components to modulate the ubiquitination status of receptors and relevant sorting proteins.
The deubiquitinating enzyme USP8 promotes trafficking and degradation of the chemokine receptor 4 at the sorting endosome.
Nash et al., Chicago, United States. In J Biol Chem, 2010
USP8 promotes trafficking and degradation of CXCR4 at the sorting endosome.
Regulation of epidermal growth factor receptor ubiquitination and trafficking by the USP8·STAM complex.
Nash et al., Chicago, United States. In J Biol Chem, 2010
a role for the USP8.STAM complex as a protective mechanism regulating early endosomal sorting of EGFR between pathways destined for lysosomal degradation and recycling.
Expression pattern of mUBPy in the brain and sensory organs of mouse during embryonic development.
Vallarino et al., Genova, Italy. In Brain Res, 2010
The spatio-temporal expression of mUBPy suggests that the enzyme may be involved in neuroregulatory processes during embryogenesis.
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