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Creatine kinase, mitochondrial 1, ubiquitous

ubiquitous mitochondrial creatine kinase, uMtCK, MtCK, UbCKmit
Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, CKB, sarcomeric mitochondrial creatine kinase, V1a, VDAC1
Papers on ubiquitous mitochondrial creatine kinase
Mg++ requirement for MtHK binding, and Mg++ stabilization of mitochondrial membranes via activation of MtHK & MtCK activities and promotion of mitochondrial permeability transition pore closure: A hypothesis on mechanisms underlying Mg++'s antioxidant and cytoprotective effects.
Golshani-Hebroni, In Gene, Jan 2016
The profound anti-apoptotic, anabolic, and anti-oxidant effects of mitochondrion bound hexokinase (MtHk), and the anti-apoptotic, anti-necrotic, and anti-oxidant functions of mitochondrial creatine kinase (MtCK) have been established over the past few decades.
Modelling in vivo creatine/phosphocreatine in vitro reveal divergent adaptations in human muscle mitochondrial respiratory control by ADP after acute and chronic exercise.
Perry et al., Stockholm, Sweden. In J Physiol, Jan 2016
We hypothesized modelling in vivo mitochondrial creatine kinase (mtCK)-dependent phosphate shuttling conditions in vitro would reveal increased sensitivity (lower Kmapp ) following acute and chronic exercise.
The Expression of Ubiquitous Mitochondrial Creatine Kinase Is Downregulated as Prostate Cancer Progression.
Kang et al., Kitakyūshū, Japan. In J Cancer, Dec 2015
Ubiquitous mitochondrial creatine kinase (uMtCK) is predominantly localized in the intermembrane space of mitochondria and catalyzes the reversible exchange of high-energy phosphate between adenosine tri-phosphate (ATP) and phosphocreatine.
Hearts of some Antarctic fishes lack mitochondrial creatine kinase.
Ortego et al., Fairbanks, United States. In Comp Biochem Physiol A Mol Integr Physiol, 2014
Overall, CK activity is similar between hearts of red- and white-blooded notothenioids but hearts of icefishes lack MtCK and have higher activities of M-CK in the cytosol compared to red-blooded fishes.
Increased serum mitochondrial creatine kinase activity as a risk for hepatocarcinogenesis in chronic hepatitis C patients.
Ikeda et al., Tokyo, Japan. In Int J Cancer, 2014
Serum mitochondrial creatine kinase (MtCK) activity was reportedly increased in cirrhotic patients although less prominent than that in hepatocellular carcinoma (HCC) patients.
High ubiquitous mitochondrial creatine kinase expression in hepatocellular carcinoma denotes a poor prognosis with highly malignant potential.
Ikeda et al., Tokyo, Japan. In Int J Cancer, 2014
We previously reported the increased serum mitochondrial creatine kinase (MtCK) activity in patients with hepatocellular carcinoma (HCC), mostly due to the increase in ubiquitous MtCK (uMtCK), and high uMtCK mRNA expression in HCC cell lines.
Hypothalamic plasticity of neuropeptide Y is lacking in brain-type creatine kinase double knockout mice with defective thermoregulation.
Van der Zee, Nijmegen, Netherlands. In Eur J Pharmacol, 2013
The cytosolic brain-type creatine kinase (CK-B) and mitochondrial ubiquitous creatine kinase (UbCKmit) are expressed in neural cells throughout the central and peripheral nervous system, where they have an important role in cellular energy homeostasis.
Dissociated expression of mitochondrial and cytosolic creatine kinases in the human brain: a new perspective on the role of creatine in brain energy metabolism.
Waldvogel et al., Auckland, New Zealand. In J Cereb Blood Flow Metab, 2013
The phosphocreatine/creatine kinase (PCr/CK) system in the brain is defined by the expression of two CK isozymes: the cytosolic brain-type CK (BCK) and the ubiquitous mitochondrial CK (uMtCK).
Cytoskeleton and regulation of mitochondrial function: the role of beta-tubulin II.
Saks et al., Innsbruck, Austria. In Front Physiol, 2012
In the heart, colocalization of β-tubulin isotype II with mitochondria suggests that it can participate in the coupling of ATP-ADP translocase (ANT), mitochondrial creatine kinase (MtCK), and VDAC (ANT-MtCK-VDAC).
Decreased neuroinflammation and increased brain energy homeostasis following environmental enrichment after mild traumatic brain injury is associated with improvement in cognitive function.
Rogozinska et al., Detroit, United States. In Acta Neuropathol Commun, 2012
In addition, levels of AMPK (adenosine monophosphate-activated protein kinase), phosphorylated AMPK and uMtCK (ubiquitous mitochondrial creatine kinase) were assessed as measures of brain energy homeostasis.
Clinical evaluation of a new creatine kinase MB activity reagent abrogating the effect of mitochondrial creatine kinase.
Nakayama et al., Tokyo, Japan. In Clin Lab, 2012
Approximately 80% of CK-MB activity determined using the current kit corresponds to MtCK activity, and ubiquitous mitochondrial creatine kinase activity constitutes approximately 90% of MtCK activity.
Regulation of respiration in muscle cells in vivo by VDAC through interaction with the cytoskeleton and MtCK within Mitochondrial Interactosome.
Saks et al., Grenoble, France. In Biochim Biophys Acta, 2012
This review describes the recent experimental data on the importance of the VDAC-cytoskeleton interactions in determining the mechanisms of energy and metabolite transfer between mitochondria and cytoplasm in cardiac cells.
Intracellular Energetic Units regulate metabolism in cardiac cells.
Guzun et al., Tallinn, Estonia. In J Mol Cell Cardiol, 2012
Beta II tubulin association with the mitochondrial outer membrane, when co-expressed with mitochondrial creatine kinase (MtCK) specifically limits the permeability of voltage-dependent anion channel for adenine nucleotides.
Systems bioenergetics of creatine kinase networks: physiological roles of creatine and phosphocreatine in regulation of cardiac cell function.
Saks et al., Grenoble, France. In Amino Acids, 2011
In particular, interactions between mitochondria and cytoskeleton resulting in selective restriction of permeability of outer mitochondrial membrane anion channel (VDAC) for adenine nucleotides and thus their recycling in mitochondria coupled to effective synthesis of PCr by mitochondrial creatine kinase, MtCK.
Structure-function relationships in feedback regulation of energy fluxes in vivo in health and disease: mitochondrial interactosome.
Seppet et al., Grenoble, France. In Biochim Biophys Acta, 2010
VDAC with associated tubulin forms a supercomplex, Mitochondrial Interactosome, with mitochondrial creatine kinase, MtCK, which is structurally and functionally coupled to ATP synthasome.
ASB9 interacts with ubiquitous mitochondrial creatine kinase and inhibits mitochondrial function.
Kwon et al., South Korea. In Bmc Biol, 2009
ASB9 interacts with the creatine kinase system and negatively regulates cell growth.
Effects of creatine and β-guanidinopropionic acid and alterations in creatine transporter and creatine kinases expression in acute seizure and chronic epilepsy models.
Kang et al., South Korea. In Bmc Neurosci, 2009
In chronic epilepsy rats, uMtCK immunoreactivity is markedly reduced in hippocampal CA1-3 pyramidal cells and hilar neurons due to massive neuronal loss.
Ubiquitous mitochondrial creatine kinase is overexpressed in the conditioned medium and the extract of LNCaP lineaged androgen independent cell lines and facilitates prostate cancer progression.
Zhou et al., Beijing, China. In Prostate, 2009
uMtCK in prostate neoplasm cells (LNCaP) contributes to overproduction of reactive oxygen species, activation of Akt signaling pathway and more aggressive phenotypes including androgen independence development.
Cardiac phenotype of mitochondrial creatine kinase knockout mice is modified on a pure C57BL/6 genetic background.
Neubauer et al., Oxford, United Kingdom. In J Mol Cell Cardiol, 2009
Mt-CK(-/-) on a C57BL/6 background do not develop LV hypertrophy or dysfunction even up to 1 year, and this may be explained by a compensatory increase in MM-CK activity and mitochondrial volume
Regulation of respiration in brain mitochondria and synaptosomes: restrictions of ADP diffusion in situ, roles of tubulin, and mitochondrial creatine kinase.
Saks et al., Grenoble, France. In Mol Cell Biochem, 2008
The role of ubiquitous mitochondrial creatine kinase (uMtCK) reaction in regulation of mitochondrial respiration was studied in purified preparations of rat brain synaptosomes and mitochondria.
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