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Ubiquitin-conjugating enzyme E2T

Ubiquitin-conjugating enzyme, UBE2T, Ubiquitin-Conjugating Enzyme E2T
The covalent conjugation of ubiquitin to proteins regulates diverse cellular pathways and proteins. Ubiquitin is transferred to a target protein through a concerted action of a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), such as UBE2T, and a ubiquitin ligase (E3) (Machida et al., 2006 [PubMed 16916645]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: Ubiquitin, CAN, Ubc9, UbcH10, Ubiquitin
Papers on Ubiquitin-conjugating enzyme
DNA Damage-Induced Foci of E2 Ubiquitin-Conjugating Enzyme are Detectable upon Co-transfection with an Interacting E3 Ubiquitin Ligase.
Song et al., Lanzhou, China. In Biochem Genet, Jan 2016
UNASSIGNED: DNA damage repair elements accumulate at DNA damage sites to form ionizing radiation-induced foci (IRIF) for damage repair.
Loss of the Ubiquitin-conjugating Enzyme Ube2W results in susceptibility to early postnatal lethality and defects in skin, immune and male reproductive systems.
Paulson et al., United States. In J Biol Chem, Dec 2015
UNASSIGNED: Ube2W ubiquitinates amino-termini of proteins rather than internal lysine residues, showing a preference for substrates with intrinsically disordered amino-termini.
The Level of Autoantibodies Targeting Eukaryote Translation Elongation Factor 1 α1 and Ubiquitin-Conjugating Enzyme 2L3 in Nondiabetic Young Adults.
Kim et al., Ch'unch'ŏn, South Korea. In Diabetes Metab J, Dec 2015
BACKGROUND: The prevalence of novel type 1 diabetes mellitus (T1DM) antibodies targeting eukaryote translation elongation factor 1 alpha 1 autoantibody (EEF1A1-AAb) and ubiquitin-conjugating enzyme 2L3 autoantibody (UBE2L3-AAb) has been shown to be negatively correlated with age in T1DM subjects.
Methionine adenosyltransferase α2 sumoylation positively regulate Bcl-2 expression in human colon and liver cancer cells.
Lu et al., Los Angeles, United States. In Oncotarget, Dec 2015
Ubiquitin-conjugating enzyme 9 (Ubc9) is required for sumoylation and inhibits apoptosis via Bcl-2 by unknown mechanism.
Elevated expression of UBE2T exhibits oncogenic properties in human prostate cancer.
Wei et al., Jinan, China. In Oncotarget, Oct 2015
Increased expression of ubiquitin-conjugating enzyme E2T (UBE2T) is reported in human prostate cancer.
AluY-mediated germline deletion, duplication and somatic stem cell reversion in UBE2T defines a new subtype of Fanconi anemia.
Hanenberg et al., Düsseldorf, Germany. In Hum Mol Genet, Oct 2015
Here, we identify the first FA patient with biallelic germline mutations in the ubiquitin E2 conjugase UBE2T.
MicroRNA-196a post-transcriptionally upregulates the UBE2C proto-oncogene and promotes cell proliferation in breast cancer.
Zhang et al., Shanghai, China. In Oncol Rep, Aug 2015
Ubiquitin-conjugating enzyme E2C (UBE2C) gene as a cellular proto-oncogene, which was overexpressed and positively correlated with miR-196a expression in breast cancer tissues, was identified as a direct target of miR-196a.
Deficiency of UBE2T, the E2 Ubiquitin Ligase Necessary for FANCD2 and FANCI Ubiquitination, Causes FA-T Subtype of Fanconi Anemia.
Smogorzewska et al., New York City, United States. In Cell Rep, Aug 2015
Here, we describe an individual presenting with typical FA features who is deficient for the ubiquitin-conjugating enzyme (E2), UBE2T.
Genome-Wide Identification, Phylogenetic and Expression Analyses of the Ubiquitin-Conjugating Enzyme Gene Family in Maize.
Jia et al., Zhanjiang, China. In Plos One, 2014
Phylogenetic analysis revealed that ZmUBC proteins could be divided into 15 subfamilies, which include 13 ubiquitin-conjugating enzymes (ZmE2s) and two independent ubiquitin-conjugating enzyme variant (UEV) groups.
Methylmercury can induce Parkinson's-like neurotoxicity similar to 1-methyl-4- phenylpyridinium: a genomic and proteomic analysis on MN9D dopaminergic neuron cells.
Chan et al., Canada. In J Toxicol Sci, 2014
A total of 7 genes/proteins including Ube2l3 (Ubiquitin-conjugating enzyme E2 L3) and Th (Tyrosine 3-monooxygenase) were changed in both genomic and proteomic analysis.
Ubiquitin-conjugating enzyme E2C: a potential cancer biomarker.
Dong et al., Sydney, Australia. In Int J Biochem Cell Biol, 2014
The ubiquitin-conjugating enzymes 2C (UBE2C) is an integral component of the ubiquitin proteasome system.
Ubiquitin-conjugating enzyme UBE2C: molecular biology, role in tumorigenesis, and potential as a biomarker.
Cowell et al., Augusta, United States. In Tumour Biol, 2012
Ubiquitin-conjugating enzyme 2C (UBE2C) participates in cell cycle progression and checkpoint control by targeted degradation of short-lived proteins.
Hypoxia disrupts the Fanconi anemia pathway and sensitizes cells to chemotherapy through regulation of UBE2T.
Wouters et al., Toronto, Canada. In Radiother Oncol, 2011
hypoxic conditions down-regulate UBE2T expression which correlates with an increased sensitivity to crosslinking agents consistent with a defective Fanconi anemia pathway
Ubiquitination and downregulation of BRCA1 by ubiquitin-conjugating enzyme E2T overexpression in human breast cancer cells.
Katagiri et al., Tokyo, Japan. In Cancer Res, 2009
Our data imply a critical role of UBE2T in development and/or progression of breast cancer through the interaction with and the regulation of the BRCA1/BARD1 complex.
FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCL.
Sung et al., New Haven, United States. In J Biol Chem, 2009
Upon the occurrence of DNA damage, FANCI becomes monoubiquitinated on Lys-523 by the UBE2T-FANCL pair.
Mechanistic insight into site-restricted monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI.
Patel et al., Cambridge, United Kingdom. In Mol Cell, 2009
This work therefore establishes a system that provides mechanistic insight into the functions of FANCL and FANCI in the catalysis of FANCD2 monoubiquitination.
Elevated expression of UBE2T in lung cancer tumors and cell lines.
He et al., Beijing, China. In Tumour Biol, 2007
UBE2T was significantly upregulated in lung cancer tissue and cell lines, suggesting involvement of UBE2T in the malignant cell phenotype.
Fanconi anemia and ubiquitination.
Huang et al., Beijing, China. In J Genet Genomics, 2007
The ubiquitin E3 ligase FANCL, an important factor of FA core complex, co-functions with a new ubiquitin conjugating enzyme UBE2T to catalyze the monoubiquitination of FANCD2.
Targeting Ubc9 for cancer therapy.
Moschos et al., Springfield, United States. In Expert Opin Ther Targets, 2005
Ubiquitin-conjugating enzyme (Ubc9) was originally thought to be a conjugating enzyme for ubiquitylation, but was later shown to be responsible for the most recently identified type of post-translational modification, (i.e., SUMO [small ubiquitin-related modifier]) conjugation or sumoylation.
Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair.
Pickart et al., Baltimore, United States. In Cell, 1999
Ubiquitin-conjugating enzyme variant (UEV) proteins resemble ubiquitin-conjugating enzymes (E2s) but lack the defining E2 active-site residue.
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