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Ubiquilin 3

ubiquilin 3, UBQLN3
Summary: This gene encodes an ubiquitin-like protein (ubiquilin) that shares high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This gene is specifically expressed in the testis, and proposed to regulate cell-cycle progression during spermatogenesis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Ubiquitin, Dsk2, CAN, CTP-11, ACID
Papers on ubiquilin 3
The ubiquilin gene family: evolutionary patterns and functional insights.
Marín, Valencia, Spain. In Bmc Evol Biol, 2013
This exceptional mammalian-specific expansion is the result of the recent emergence of four new genes, three of them (UBQLN3, UBQLN5 and UBQLNL) with precise testis-specific expression patterns that indicate roles in the postmeiotic stages of spermatogenesis.
Potential biomarkers of nonobstructive azoospermia identified in microarray gene expression analysis.
Kurpisz et al., Poznań, Poland. In Fertil Steril, 2013
AKAP4, UBQLN3, CAPN11, GGN, SPACA4, SPATA3, and FAM71F1 were the most significantly down-regulated genes in infertile patients.
Identification of the cancer/testis antigens AKAP3 and CTp11 by SEREX in hepatocellular carcinoma.
Lee et al., Yangsan, South Korea. In Oncol Rep, 2012
We isolated 3 different antigens, AKAP3, CTp11, and UBQLN3.
Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters.
Hardison et al., Seattle, United States. In Proc Natl Acad Sci U S A, 2001
Includes the identification of the ubiquilin 3 gene upstream of the beta-globin gene cluster and surrounding olfactory receptor genes.
Molecular cloning, chromosome mapping and characterization of UBQLN3 a testis-specific gene that contains an ubiquitin-like domain.
Feldhaus et al., Seattle, United States. In Gene, 2000
In the present study, we report the cloning of the cDNA for human ubiquilin 3 (UBQLN3).
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