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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Ubiquitin-conjugating enzyme E2Q family member 2

Top mentioned proteins: Ubiquitin, PRKAG2, DAC, Dab2, STC
Papers on UBE2Q2
Practical Experience of the Application of a Weighted Burden Test to Whole Exome Sequence Data for Obesity and Schizophrenia.
UK10K Consortium et al., London, United Kingdom. In Ann Hum Genet, Jan 2016
Promoter Methylation Status of Two Novel Human Genes, UBE2Q1 and UBE2Q2, in Colorectal Cancer: a New Finding in Iranian Patients.
Seghatoleslam et al., Shīrāz, Iran. In Asian Pac J Cancer Prev, 2014
Recently it has been reported that expression of newly characterized human genes, UBE2Q1 and UBE2Q2, putative members of ubiquitin-conjugating enzyme family (E2), has been also changed in colorectal cancer.
A complex regulatory network coordinating cell cycles during C. elegans development is revealed by a genome-wide RNAi screen.
Saito et al., Martinsried, Germany. In G3 (bethesda), 2014
Moreover, we characterized ubc-25, a gene encoding an E2 ubiquitin-conjugating enzyme whose human ortholog, UBE2Q2, is deregulated in several cancers.
Exploring the effects of homeopathic Apis mellifica preparations on human gene expression profiles.
Dolara et al., Florence, Italy. In Homeopathy, 2014
We confirmed these data by RT-PCR analyses on 5 selected candidate genes (IL1β, CD46, ATF1, UBE2Q2 and MT1X).
Expression Status of UBE2Q2 in Colorectal Primary Tumors and Cell Lines.
Owji et al., Shīrāz, Iran. In Iran J Med Sci, 2014
The novel human gene, UBE2Q2, with a putative ubiquitin-conjugating enzyme activity, is reported to be overexpressed in some malignancies.
Generalization of associations of kidney-related genetic loci to American Indians.
Cole et al., Hyattsville, United States. In Clin J Am Soc Nephrol, 2014
RESULTS: This study identified significant associations of single nucleotide polymorphisms with estimated GFR in or nearby PRKAG2, SLC6A13, UBE2Q2, PIP5K1B, and WDR72 (P<2.1 × 10(-3) to account for multiple testing).
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
Gieger et al., Freiburg, Germany. In Nat Genet, 2013
By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we identified and replicated 28 genome-wide significant loci in association with serum urate concentrations (18 new regions in or near TRIM46, INHBB, SFMBT1, TMEM171, VEGFA, BAZ1B, PRKAG2, STC1, HNF4G, A1CF, ATXN2, UBE2Q2, IGF1R, NFAT5, MAF, HLF, ACVR1B-ACVRL1 and B3GNT4).
Expression of UBE2Q2, a putative member of the ubiquitin-conjugating enzyme family in pediatric acute lymphoblastic leukemia.
Owji et al., Shīrāz, Iran. In Arch Iran Med, 2012
The newly characterized human gene, UBE2Q2, may have implications for the pathogenesis of acute lymphoblastic leukemia.
Association of eGFR-Related Loci Identified by GWAS with Incident CKD and ESRD.
CKDGen Consortium et al., Regensburg, Germany. In Plos Genet, 2011
SNPs at 11 of the 16 loci (UMOD, PRKAG2, ANXA9, DAB2, SHROOM3, DACH1, STC1, SLC34A1, ALMS1/NAT8, UBE2Q2, and GCKR) were associated with incident CKD; p-values ranged from p = 4.1e-9 in UMOD to p = 0.03 in GCKR.
Chronic kidney disease: novel insights from genome-wide association studies.
Heid et al., Regensburg, Germany. In Kidney Blood Press Res, 2010
UMOD, SHROOM3, STC1, LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2/SH2B3, DACH1, UBE2Q2, and SLC7A9 were uncovered as loci associated with estimated glomerular filtration rate (eGFR) and CKD, and CUBN as a locus for albuminuria in cross-sectional data of general population studies.
Genome-wide association studies in nephrology research.
Köttgen, Freiburg, Germany. In Am J Kidney Dis, 2010
For example, common variants in the UMOD and PRKAG2 genes are associated with risk of chronic kidney disease; variants in CLDN14 with risk of kidney stone disease; and variants in or near SHROOM3, STC1, LASS2, GCKR, NAT8/ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, FAM122A/PIP5K1B, ATXN2, DACH1, UBE2Q2/FBXO22, and SLC7A9, with differences in glomerular filtration rate.
New loci associated with kidney function and chronic kidney disease.
Fox et al., Baltimore, United States. In Nat Genet, 2010
Follow-up of the 23 new genome-wide-significant loci (P < 5 x 10(-8)) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3).
Overexpression of the novel human gene, UBE2Q2, in breast cancer.
Owji et al., Shīrāz, Iran. In Cancer Genet Cytogenet, 2010
In the 21 breast cancer cases investigated, a high increase in UBE2Q2 expression was found in 8 breast cancers (38.1%), a moderately increased UBE2Q2 expression was observed in 7 cases (33.3%), and no sig. changes were detected in 6 cases (28.6%).
Ubiquitin-conjugating enzyme UBE2Q2 suppresses cell proliferation and is down-regulated in recurrent head and neck cancer.
Hatakeyama et al., Sapporo, Japan. In Mol Cancer Res, 2009
Found high expression levels of UBE2Q2 in human head and neck carcinoma cell lines and cancer tissues; found the level of UBE2Q2 is decreased in cell lines and cancer tissues that have resistance to CDDP or docetaxel.
Feeding induced changes in the hypothalamic transcriptome.
St-Amand et al., Québec, Canada. In Clin Chim Acta, 2009
Among these, 2 transcripts have mitochondrial functions (MtCo1, Ppid), 3 are involved in protein transport and regulation (Ube2q2, Mup1, Sec13), 1 in cellular pH control (Slc4a3) and another 1 has a role in the epigenetic control of gene expression (Setd3).
Inactivation of the ubiquitin conjugating enzyme UBE2Q2 causes a prophase arrest and enhanced apoptosis in response to microtubule inhibiting agents.
Crawford et al., Birmingham, United States. In Oncogene, 2007
Inhibition of the UBE2Q2 protein causes cells to undergo a prolonged prophase arrest suggesting that UBE2Q2 normally functions to antagonize an early mitotic checkpoint.
Analysis of a novel human gene, LOC92912, over-expressed in hypopharyngeal tumours.
Wasylyk et al., Strasbourg, France. In Biochem Biophys Res Commun, 2006
the novel LOC92912 gene is characterized. It is over-expressed in hypopharyngeal tumours. Its functions may be linked with the cytoskeleton; it may represent a new target for cancer therapeutics.
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