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Ubiquitin-conjugating enzyme E2H

UBE2H, UBC8, E220K, UbcH2
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Three alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [provided by RefSeq, Feb 2011] (from NCBI)
Top mentioned proteins: Ubiquitin, V1a, ACID, SFT, UBC4
Papers on UBE2H
PLANT U-BOX PROTEIN10 Regulates MYC2 Stability in Arabidopsis.
Chua et al., Nanjing, China. In Plant Cell, Jul 2015
MYC2 was efficiently polyubiquitinated by PUB10 with UBC8 as an E2 enzyme and the conserved C249 in PUB10 was required for activity.
An exome study of Parkinson's disease in Sardinia, a Mediterranean genetic isolate.
Bonifati et al., Rotterdam, Netherlands. In Neurogenetics, 2015
We identified novel moderately rare variants in several genes, including SCAPER, HYDIN, UBE2H, EZR, MMRN2 and OGFOD1 that were specifically present in PD patients or enriched among them, nominating these as novel candidate risk genes for PD, although no variants achieved genome-wide significance after Bonferroni correction.
RING-type ubiquitin ligase McCPN1 catalyzes UBC8-dependent protein ubiquitination and interacts with Argonaute 4 in halophyte ice plant.
Yen et al., T'ai-chung-shih, Taiwan. In Plant Physiol Biochem, 2014
The results showed that McUBC2, a member of the UBC8 family, stimulated the autoubiquitination activity of McCPN1, while McUBC1, a homolog of the UBC35 family, did not.
Mitsugumin 53 (MG53) ligase ubiquitinates focal adhesion kinase during skeletal myogenesis.
Ko et al., Seoul, South Korea. In J Biol Chem, 2014
The FAK protein was associated with the E2 enzyme UBE2H and the E3 enzyme MG53 in endogenous and exogenous immunoprecipitation experiments.
Ubiquitination of the tomato cell death suppressor Adi3 by the RING E3 ubiquitin ligase AdBiL.
Devarenne et al., College Station, United States. In Biochem Biophys Res Commun, 2013
Using in vitro ubiquitination assays we show that AdBiL is an active E3 ubiquitin ligase using the E2 ubiquitin ligase UBC8 to ubiquitinate Adi3.
MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling.
Ko et al., Seoul, South Korea. In Nat Commun, 2012
Here, we show that MG53 is an ubiquitin E3 ligase that induces IRS-1 ubiquitination with the help of an E2-conjugating enzyme, UBE2H.
Identification and association analysis of several hundred single nucleotide polymorphisms within candidate genes for back fat thickness in Italian Large White pigs using a selective genotyping approach.
Russo et al., Bologna, Italy. In J Anim Sci, 2012
The list of significant markers also included SNP in additional genes (ABHD16A, ABHD5, ACP2, ALMS1, APOA2, ATP1A2, CALR, COL14A1, CTSF, DARS, DECR1, ENPP1, ESR1, GH1, GHRL, GNMT, IKBKB, JAK3, MTTP, NFKBIA, NT5E, PLAT, PPARG, PPP2R5D, PRLR, RRAGD, RFC2, SDHD, SERPINF1, UBE2H, VCAM1, and WAT).
UBR2 of the N-end rule pathway is required for chromosome stability via histone ubiquitylation in spermatocytes and somatic cells.
Kwon et al., Pittsburgh, United States. In Plos One, 2011
UBR2 functions as a scaffold E3 that promotes HR6B/UbcH2-dependent ubiquitylation of H2A and H2B but not H3 and H4, through a mechanism distinct from typical polyubiquitylation.
Variable renal phenotype in a family with an INF2 mutation.
Cheong et al., Seoul, South Korea. In Pediatr Nephrol, 2011
In the family, two siblings and their father had a heterozygous p.E220K mutation on INF2.
The Cdc48-Ufd1-Npl4 complex is central in ubiquitin-proteasome triggered catabolite degradation of fructose-1,6-bisphosphatase.
Wolf et al., Stuttgart, Germany. In Biochem Biophys Res Commun, 2010
Prior to proteasomal degradation, polyubiquitination of the enzyme occurs via the ubiquitin-conjugating enzymes Ubc1, Ubc4, Ubc5 and Ubc8 in conjunction with a novel multi-subunit ubiquitin ligase, the Gid complex.
miR-451 enhances erythroid differentiation in K562 cells.
Prchal et al., Praha, Czech Republic. In Leuk Lymphoma, 2010
Microarray data suggested potential targets regulated by miR-451: UBE2H, ARPP-19; and by miR-150: MS4A3, AGA, PTPRR.
Targets of the Tal1 transcription factor in erythrocytes: E2 ubiquitin conjugase regulation by Tal1.
Leutz et al., Frankfurt am Main, Germany. In J Biol Chem, 2010
Tal1 expression activated UBE2H expression, whereas Tal1 knock-down reduced UBE2H expression and ubiquitin transfer activity.
Association study of the ubiquitin conjugating enzyme gene UBE2H in sporadic ALS.
French ALS Study Group et al., Montpellier, France. In Amyotroph Lateral Scler, 2009
Results suggest that the UBE2H gene is not implicated in sporadic ALS.
A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma.
Largaespada et al., Minneapolis, United States. In Nat Biotechnol, 2009
These encode genes, such as EGFR and MET, previously associated with HCC and others, such as UBE2H, that are potential new targets for treating this neoplasm.
Epigenetic and proteolytic inactivation of 14-3-3sigma in breast and prostate cancers.
Inoue et al., Gobō, Japan. In Semin Cancer Biol, 2006
The E2 ubiquitin conjugating enzyme UBC8 and Efp also mediates ISG15 modification of 14-3-3sigma.
Mutation screening and association study of the UBE2H gene on chromosome 7q32 in autistic disorder.
Andres et al., Tours, France. In Psychiatr Genet, 2003
UBE2H gene could be one of the 7q-susceptibility loci for autistic disorder.
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