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Ubiquitin-conjugating enzyme E2L 3

UbcH7, UbcM4, UBE2L3
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: Ubiquitin, CAN, E3 ubiquitin ligase, UbcH8, UBE3A
Papers on UbcH7
Host genetic variants influencing the clinical course of Hepatitis B virus infection.
Tanaka et al., Nagoya, Japan. In J Med Virol, Mar 2016
Other polymorphisms in or near the genes EHMT2, TCF19, and HLA-C, located near HLA class II loci, and UBE2L3 were also associated with persistent HBV infection.
Identification of Ten Additional Susceptibility Loci for Ulcerative Colitis Through Immunochip Analysis in Koreans.
Song et al., Seoul, South Korea. In Inflamm Bowel Dis, Jan 2016
RESULTS: We confirmed the associations of 10 known UC risk loci in Koreans: rs76418789 in IL23R (combined P = 1.25 × 10), rs4728142 in IRF5 (combined P = 3.17 × 10), rs1830610 near JAK2 (combined P = 2.28 × 10), rs1555791 near TNFRSF14 (combined P = 1.62 × 10), rs880790 between IL10-IL19 (combined P = 3.73 × 10), rs10185424 between IL1R2-IL1R1 (combined P = 1.54 × 10), rs6478108 in TNFSF15 (combined P = 9.28 × 10), rs861857 between UBE2L3-YDJC (combined P = 3.05 × 10), rs1801274 in FCGR2A (discovery P = 1.54 × 10), and rs17085007 between GPR12-USP12 (discovery P = 3.64 × 10).
The Level of Autoantibodies Targeting Eukaryote Translation Elongation Factor 1 α1 and Ubiquitin-Conjugating Enzyme 2L3 in Nondiabetic Young Adults.
Kim et al., Ch'unch'ŏn, South Korea. In Diabetes Metab J, Dec 2015
BACKGROUND: The prevalence of novel type 1 diabetes mellitus (T1DM) antibodies targeting eukaryote translation elongation factor 1 alpha 1 autoantibody (EEF1A1-AAb) and ubiquitin-conjugating enzyme 2L3 autoantibody (UBE2L3-AAb) has been shown to be negatively correlated with age in T1DM subjects.
Activation of AHR mediates the ubiquitination and proteasome degradation of c-Fos through the induction of Ubcm4 gene expression.
Elizondo et al., Mexico. In Toxicology, Dec 2015
Here, we showed that activation of AHR by TCDD and β-naphthoflavone (β-NF) results in Ubcm4 gene induction accompanied by an increase in protein levels.
A Ubl/ubiquitin switch in the activation of Parkin.
Gehring et al., Montréal, Canada. In Embo J, Nov 2015
Measurements of the E2 ubiquitin-conjugating enzyme UbcH7 binding to Parkin and Parkin E3 ligase activity suggest that Parkin phosphorylation regulates E3 ligase activity downstream of pUb binding.
Polymorphisms in Genes Involved in EGFR Turnover Are Predictive for Cetuximab Efficacy in Colorectal Cancer.
Lenz et al., München, Germany. In Mol Cancer Ther, Oct 2015
The following SNPs involved in EGFR degradation were analyzed in a screening cohort of 108 patients treated with cetuximab in the chemorefractory setting: c-CBL (rs7105971; rs4938637; rs4938638; rs251837), EPS15 (rs17567; rs7308; rs1065754), NAE1 (rs363169; rs363170; rs363172), SH3KBP1 (rs7051590; rs5955820; rs1017874; rs11795873), SGIP1 (rs604737; rs6570808; rs7526812), UBE2M (rs895364; rs895374), and UBE2L3 (rs5754216).
Dense genotyping of immune-related loci in idiopathic inflammatory myopathies confirms HLA alleles as the strongest genetic risk factor and suggests different genetic background for major clinical subgroups.
Myositis Genetics Consortium et al., Stockholm, Sweden. In Ann Rheum Dis, Oct 2015
Nine regions were associated at a significance level of p<2.25×10(-5), including UBE2L3, CD28 and TRAF6, with evidence of independent effects within STAT4.
Effect of UBE2L3 genotype on regulation of the linear ubiquitin chain assembly complex in systemic lupus erythematosus.
Vyse et al., London, United Kingdom. In Lancet, Mar 2015
BACKGROUND: A single risk haplotype across UBE2L3 is strongly associated with systemic lupus erythematosus (SLE) and many other autoimmune diseases.
Casitas B-Lineage Lymphoma RING Domain Inhibitors Protect Mice against High-Fat Diet-Induced Obesity and Insulin Resistance.
Sun et al., Chengdu, China. In Plos One, 2014
The casitas b-lineage lymphoma (c-Cbl) is an important adaptor protein with an intrinsic E3 ubiquitin ligase activity that interacts with E2 proteins such as UbCH7.
Ubiquitin is phosphorylated by PINK1 to activate parkin.
Matsuda et al., Tokyo, Japan. In Nature, 2014
Furthermore, phosphomimetic ubiquitin accelerates discharge of the thioester conjugate formed by UBCH7 (also known as UBE2L3) and ubiquitin (UBCH7∼ubiquitin) in the presence of parkin in vitro, indicating that it acts allosterically.
New loci associated with chronic hepatitis B virus infection in Han Chinese.
Shen et al., Nanjing, China. In Nat Genet, 2013
P = 9.49 × 10(-14)) and rs4821116 at 22q11.21 (in UBE2L3, OR = 0.82, P = 1.71 × 10(-12)).
Association of UBE2L3 polymorphisms with diffuse cutaneous systemic sclerosis in a Japanese population.
Tsuchiya et al., In Ann Rheum Dis, 2012
UBE2L3 was found to be a shared susceptibility gene for siffuse cutaneous systemic sclerosis in a Japanese population.
A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus.
Gaffney et al., Oklahoma City, United States. In Genes Immun, 2012
The results suggest that variants carried on the SLE-associated UBE2L3 risk haplotype influence autoimmunity by modulating UBCH7 expression.
Crystal structures of two bacterial HECT-like E3 ligases in complex with a human E2 reveal atomic details of pathogen-host interactions.
Chen et al., West Lafayette, United States. In Proc Natl Acad Sci U S A, 2012
Crystal structures of two bacterial E3s, Salmonella SopA and Escherichia coli NleL, both in complex with human E2 UbcH7, are reported.
The autoimmune disease risk allele of UBE2L3 in African American patients with systemic lupus erythematosus: a recessive effect upon subphenotypes.
Niewold et al., Chicago, United States. In J Rheumatol, 2012
The interaction between UBE2L3 genotype and autoantibodies upon serum IFN-alpha suggests a biological role for this locus in patients with systemic lupus erythematosus.
UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids.
Klevit et al., Seattle, United States. In Nature, 2011
UBCH7 exhibits activity with the RING-in-between-RING (RBR) family of E3s that includes parkin (also known as PARK2) and human homologue of ariadne (HHARI; also known as ARIH1)
Nef-mediated lipid raft exclusion of UbcH7 inhibits Cbl activity in T cells to positively regulate signaling.
McMichael et al., Oxford, United Kingdom. In Immunity, 2005
Here, the E2 ubiquitin-conjugating enzyme UbcH7, which acts in conjunction with c-Cbl, is absent from lipid rafts.
Part I: parkin-associated proteins and Parkinson's disease.
Rovelli et al., Basel, Switzerland. In Neuropharmacology, 2003
Firstly, the E2 ubiquitin conjugating proteins called UbcH7 and UbcH8 interact with parkin.
Parkin is linked to the ubiquitin pathway.
Mizuno et al., Tokyo, Japan. In J Mol Med (berl), 2001
Parkin, the causative gene of AR-JP, encodes a 52-kDa protein that is a RING-type ubiquitin (Ub) protein ligase (E3) collaborating with a Ub-conjugating enzyme (E2) belonging to a cognate class of UbcH7 or UbcH8.
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