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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Ubiquitin-conjugating enzyme E2C

UbcH10, UBE2C, ubiquitin-conjugating enzyme E2C
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for the destruction of mitotic cyclins and for cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009] (from NCBI)
Top mentioned proteins: Ubiquitin, CAN, PCNA, APC, HAD
Papers using UbcH10 antibodies
Cdc20: a WD40 activator for a cell cycle degradation machine
van Deursen Jan M. et al., In The Journal of Cell Biology, 2006
... UbcH10 transgenic mice and DMBA treatment ...
Papers on UbcH10
Co-targeting Androgen Receptor Splice Variants and mTOR signaling pathway for the Treatment of Castration-Resistant Prostate Cancer.
Sadar et al., Botswana. In Clin Cancer Res, Jan 2016
RESULTS: EPI-002 had antitumor activity in enzalutamide-resistant LNCaP95 cells that was associated with decreased expression of AR-V target genes (e.g., UBE2C).
Changes in the transcriptome of bovine ovarian cortex during follicle activation in vitro.
Fortune et al., Ithaca, United States. In Physiol Genomics, Dec 2015
The transcript encoding ubiquitin-conjugating enzyme E2C (UBE2C) was significantly upregulated during follicle activation, and Ingenuity Pathways Analysis revealed that UBE2C can interact with the tumor suppressor phosphatase and tensin homolog (PTEN).
MicroRNA-196a post-transcriptionally upregulates the UBE2C proto-oncogene and promotes cell proliferation in breast cancer.
Zhang et al., Shanghai, China. In Oncol Rep, Aug 2015
Ubiquitin-conjugating enzyme E2C (UBE2C) gene as a cellular proto-oncogene, which was overexpressed and positively correlated with miR-196a expression in breast cancer tissues, was identified as a direct target of miR-196a.
Atomic structure of the APC/C and its mechanism of protein ubiquitination.
Barford et al., Cambridge, United Kingdom. In Nature, Jul 2015
Here we use cryo-electron microscopy to determine atomic structures of APC/C-coactivator complexes with either Emi1 or a UbcH10-ubiquitin conjugate.
High EGFR_1 Inside-Out Activated Inflammation-Induced Motility through SLC2A1-CCNB2-HMMR-KIF11-NUSAP1-PRC1-UBE2C.
Zhang et al., Beijing, China. In J Cancer, 2014
Our identified EGFR_1 inside-out upstream activated molecular network showed SLC2A1 (solute carrier family 2 (facilitated glucose transporter) member 1), CCNB2 (cyclin B2), HMMR (hyaluronan-mediated motility receptor (RHAMM)), KIF11 (kinesin family member 11), NUSAP1 (nucleolar and spindle associated protein 1), PRC1 (protein regulator of cytokinesis 1), UBE2C (ubiquitin-conjugating enzyme E2C) in high lung adenocarcinoma.
The RNA-binding protein Sam68 regulates expression and transcription function of the androgen receptor splice variant AR-V7.
Rajan et al., Stockholm, Sweden. In Sci Rep, 2014
Using a luciferase reporter, we demonstrate that Sam68 co-activates ligand-independent AR-V7 transcriptional activity in an RNA-binding-independent manner, and controls expression of the endogenous AR-V7-specific gene target UBE2C.
Molecular architecture and mechanism of the anaphase-promoting complex.
Barford et al., London, United Kingdom. In Nature, 2014
This transition is accompanied by increased flexibility of the cullin-RING subunits and enhanced affinity for UBCH10-ubiquitin, changes which may contribute to coactivator-mediated stimulation of APC/C E3 ligase activity.
Ubiquitin-conjugating enzyme E2C: a potential cancer biomarker.
Dong et al., Sydney, Australia. In Int J Biochem Cell Biol, 2014
The ubiquitin-conjugating enzymes 2C (UBE2C) is an integral component of the ubiquitin proteasome system.
Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex.
Kirschner et al., Boston, United States. In Nat Cell Biol, 2013
The zinc-binding region of Emi1 allows multiple monoubiquitylation of substrates, but preferentially suppresses the ubiquitin chain elongation by UBCH10.
Dominant negative Ubiquitin-conjugating enzyme E2C sensitizes cervical cancer cells to radiation.
Rajkumar et al., Chennai, India. In Int J Radiat Biol, 2012
growth rate of SiHa and HeLa transfected with dominant negative-UBE2C was significantly reduced compared to vector control
UbcH10 expression in benign, hyperplastic, and malignant endometrial curetted materials: a tissue microarray study.
Karagoz et al., Samsun, Turkey. In Int J Surg Pathol, 2012
Overexpression of UbcH10 may be a useful indicator of endometrial carcinoma.
Prognostic significance of UBE2C mRNA expression in high-risk early breast cancer. A Hellenic Cooperative Oncology Group (HeCOG) Study.
Fountzilas et al., Athens, Greece. In Ann Oncol, 2012
High UBE2C mRNA expression was found to be of adverse prognostic significance in high-risk breast cancer patients
Ubiquitin-conjugating enzyme UBE2C: molecular biology, role in tumorigenesis, and potential as a biomarker.
Cowell et al., Augusta, United States. In Tumour Biol, 2012
Ubiquitin-conjugating enzyme 2C (UBE2C) participates in cell cycle progression and checkpoint control by targeted degradation of short-lived proteins.
APC/C-mediated multiple monoubiquitylation provides an alternative degradation signal for cyclin B1.
King et al., Boston, United States. In Nat Cell Biol, 2012
Here we demonstrate that multiple monoubiquitylation of cyclin B1, catalysed by UBCH10 or UBC4/5, is sufficient to target cyclin B1 for destruction by the proteasome.
Androgen receptor-driven chromatin looping in prostate cancer.
Wang et al., Columbus, United States. In Trends Endocrinol Metab, 2011
UBE2C) involved in prostate cancer growth through chromatin looping.
Phospho-MED1-enhanced UBE2C locus looping drives castration-resistant prostate cancer growth.
Wang et al., Columbus, United States. In Embo J, 2011
Mediator complex subunit (MED)1 phosphorylation leads to UBE2C locus looping, UBE2C gene expression and cell growth in castration-resistant prostate cancer.
[Effect of UBE2C overexpression on the proliferation of 293T cell line].
Li et al., Shiqi, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2011
Effect of UBE2C overexpression on the proliferation of 293T cell line
Assembly of k11-linked ubiquitin chains by the anaphase-promoting complex.
Rape, Berkeley, United States. In Subcell Biochem, 2009
In particular, we discuss the mechanism of assembly for K11-linked chains by the human anaphase-promoting complex and its physiological E2s UbcH10 and Ube2S and we speculate on the particularities of these noncanonical chains in cells.
UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit.
Venkitaraman et al., Cambridge, United Kingdom. In Nat Cell Biol, 2009
In vitro, UBE2S elongates ubiquitin chains initiated by the E2 enzymes UBCH10 and UBCH5, enhancing the degradation of APC/C substrates by the proteasome.
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