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Small nuclear ribonucleoprotein 70kDa

U1RNP, U1 small nuclear ribonucleoprotein, U1-70K
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Top mentioned proteins: HAD, Phosphogluconate Dehydrogenase, CAN, SSB, CK7
Papers using U1RNP antibodies
Autoimmune ovarian disease: mechanism of disease induction and prevention
Fu Shu Man et al., In The Journal of Experimental Medicine, 1996
... The cDNAs encoding human Ro60, 70 kD U1-RNP (gifts from Jack Keene, Duke University, Durham, NC), SmB and SmD (from Joe Craft, Yale University, New Haven, CT), were cloned into the pQE expression vectors (Qiagen Inc., Chatsworth, CA) to ...
Papers on U1RNP
Comparison of the clinical utility of the Elia CTD Screen to indirect immunofluorescence on Hep-2 cells.
Reicht et al., In Clin Chem Lab Med, Jan 2016
ECS had a better detection rate for anti-dsDNA, -SSA/Ro, -SSB/La, -U1RNP and -Jo-1 antibodies, whereas IIF was superior in the detection of anti-CENP-B antibodies as well as anti-histone, -nucleosome and -Pl-12 antibodies, which are not included in the ECS antigen panel.
Symptomatic and electrodiagnostic features of peripheral neuropathy in scleroderma.
Polydefkis et al., Baltimore, United States. In Arthritis Care Res (hoboken), Jan 2016
p=0.04), and have anti-U1 RNP antibodies (23.5% vs 0%, p=0.009) than those without neuropathy.
The Central Region of the Drosophila Co-repressor Groucho as a Regulatory Hub.
Courey et al., Los Angeles, United States. In J Biol Chem, Jan 2016
The positive regulators include components of the spliceosomal subcomplex U1 small nuclear ribonucleoprotein (U1 snRNP).
Association of HLA-DRB1 alleles with susceptibility to mixed connective tissue disease in Polish patients.
Jurkowska et al., Warsaw, Poland. In Tissue Antigens, Dec 2015
UNASSIGNED: Mixed connective tissue disease (MCTD) is a systemic autoimmune disease, originally defined as a connective tissue inflammatory syndrome with overlapping features of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), polymyositis/dermatomyositis (PM/DM) and systemic sclerosis (SSc), characterized by the presence of antibodies against components of the U1 small nuclear ribonucleoprotein (U1snRNP).
Juvenile, adult and late-onset systemic lupus erythematosus: a long term follow-up study from a geographic and ethnically homogeneous population.
Carreño et al., Madrid, Spain. In Clin Exp Rheumatol, Nov 2015
Low serum complement, anti-dsDNA, anti-U1RNP and anti-Sm antibodies were more common in the juvenile-onset group.
Insights into the U1 small nuclear ribonucleoprotein complex superfamily.
O'Reilly et al., São Paulo, Brazil. In Wiley Interdiscip Rev Rna, 2015
The 164 bp U1 small nuclear (sn) RNA is one of the most abundant noncoding (nc) RNA in human cells, estimated to be in the region of 10(6) copies/cell.
U1 interference (U1i) for antiviral approaches.
Fortes et al., Pamplona, Spain. In Adv Exp Med Biol, 2014
U1 snRNP (U1 small nuclear ribonucleoprotein) is an essential component of the splicing machinery.
The clinical phenotype associated with myositis-specific and associated autoantibodies: a meta-analysis revisiting the so-called antisynthetase syndrome.
Cottin et al., Lyon, France. In Autoimmun Rev, 2014
Two investigators independently extracted data on study design, patient characteristics, and clinical features (interstitial lung disease [ILD], fever, mechanic's hands [MH], Raynaud's phenomenon [RPh], arthralgia, sclerodactyly, cancer and dermatomyositis-specific rash) according to the presence of myositis-specific (anti-aminoacyl-transfer RNA synthetase [ARS], anti-signal recognition particle [anti-SRP] and anti-Mi2) and myositis-associated (anti-PM/Scl, anti-U1-RNP and anti-Ku) autoantibodies.
The diagnosis and classification of mixed connective tissue disease.
Bombardieri et al., Pisa, Italy. In J Autoimmun, 2014
The term "mixed connective tissue disease" (MCTD) concerns a systemic autoimmune disease typified by overlapping features between two or more systemic autoimmune diseases and the presence of antibodies against the U1 small nuclear ribonucleoprotein autoantigen (U1snRNP).
Promoter directionality is controlled by U1 snRNP and polyadenylation signals.
Sharp et al., Cambridge, United States. In Nature, 2013
De novo motif analysis shows PAS signals and U1 small nuclear ribonucleoprotein (snRNP) recognition sites to be the most depleted and enriched sequences, respectively, in the sense direction relative to the upstream antisense direction.
[Autoantibodies and their clinical characteristics in systemic sclerosis].
Hamaguchi, Kanazawa, Japan. In Nihon Rinsho Meneki Gakkai Kaishi, 2012
Other serum ANA found in SSc include anti-Th/To Ab, anti-U3RNP Ab, anit-human upstream-binding protein (hUBF) Ab, anti-centriole Ab, anti-U1RNP Ab, anti-Ku Ab, and anti-PM-Scl Ab.
U1-small nuclear ribonucleoprotein activates the NLRP3 inflammasome in human monocytes.
Kang et al., New Haven, United States. In J Immunol, 2012
U1-snRNP activates the NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome in CD14+ human monocytes dependently of anti-U1-snRNP Abs, leading to interleukin (IL)-1beta production.
Potential role of molecular mimicry between human U1-70 kDa and fungal proteins in the development of T-cell mediated anti-U1-70 kDa autoimmunity.
Guarneri et al., Messina, Italy. In Immunopharmacol Immunotoxicol, 2011
data identify some fungal proteins as possible triggers of anti-U1-70 kDa autoimmunity via molecular mimicry.
Interaction between the RNA binding domains of Ser-Arg splicing factor 1 and U1-70K snRNP protein determines early spliceosome assembly.
Ghosh et al., San Diego, United States. In Proc Natl Acad Sci U S A, 2011
the hypo-phosphorylated RS domain of SRSF1 interacts with its own RRM, thus competing with U1-70K binding, whereas the hyper-phosphorylated RS domain permits the formation of a ternary complex containing ESE, an SR protein, and U1 snRNP
U1 snRNP protects pre-mRNAs from premature cleavage and polyadenylation.
Dreyfuss et al., Philadelphia, United States. In Nature, 2011
In eukaryotes, U1 small nuclear ribonucleoprotein (snRNP) forms spliceosomes in equal stoichiometry with U2, U4, U5 and U6 snRNPs; however, its abundance in human far exceeds that of the other snRNPs.
Splicing-independent recruitment of U1 snRNP to a transcription unit in living cells.
Bensaude et al., Paris, France. In J Cell Sci, 2010
Recruitment of RNAPII, U1-70K and ASF/SF2 protein to transcription sites is splicing independent.
Human parvovirus B19 nonstructural protein NS1 enhanced the expression of cleavage of 70 kDa U1-snRNP autoantigen.
Hsu et al., T'ai-chung-shih, Taiwan. In J Biomed Sci, 2009
crucial association of B19-NS1 in development of autoimmunity by inducing apoptosis and specific cleavage of 70 kDa U1-snRNP
Crystal structure of human spliceosomal U1 snRNP at 5.5 A resolution.
Nagai et al., Cambridge, United Kingdom. In Nature, 2009
Human spliceosomal U1 small nuclear ribonucleoprotein particles (snRNPs), which consist of U1 small nuclear RNA and ten proteins, recognize the 5' splice site within precursor messenger RNAs and initiate the assembly of the spliceosome for intron excision.
Gene silencing by synthetic U1 adaptors.
Gunderson et al., United States. In Nat Biotechnol, 2009
U1 Adaptors are bifunctional oligonucleotides with a 'target domain' complementary to a site in the target gene's terminal exon and a 'U1 domain' that binds to the U1 small nuclear RNA component of the U1 small nuclear ribonucleoprotein (U1 snRNP) splicing factor.
Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock.
Manley et al., New York City, United States. In Nature, 2004
We further show that dephosphorylated SRp38 interacts with a U1 small nuclear ribonucleoprotein particle (snRNP) protein, and that this interaction interferes with 5'-splice-site recognition by the U1 snRNP.
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