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tyrosinase, Monophenol Monooxygenase
The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene. [provided by RefSeq, Oct 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, V1a, Microphthalmia-Associated Transcription Factor, HAD
Papers using tyrosinase antibodies
Mechanistic study on growth suppression and apoptosis induction by targeting hepatoma-derived growth factor in human hepatocellular carcinoma HepG2 cells
Franken Sebastian et al., In BMC Cancer, 2008
... Tyr-HDGF-mRNA expressed from the Tyrosinase-HDGFgene construct could only be detected in samples from the transgenic animal (red arrows; 861 ...
Imaging of multiple mRNA targets using quantum dot based in situ hybridization and spectral deconvolution in clinical biopsies.
Abraham Edathara, In PLoS ONE, 2005
... with another transgenic mouse lines expressing the reverse tetracycline transactivator under the control of the tyrosinase promoter/enhancer elements (designated Tyr-rtTA) to produce cohorts of single (Tet-BRAF*) and double (designated iBRAF*, Tet-BRAF*; Tyr-rtTA) transgenic animals ...
Measurement of color parameters of psoriatic plaques by narrow-band reflectance spectrophotometry and tristimulus colorimetry
Chang Te-Sheng et al., In International Journal of Molecular Sciences, 1993
... Anti-tyrosinase antibodies (#62914) and protease inhibitor cocktail were obtained from Abcam (Cambridge, MA, USA) ...
Papers on tyrosinase
Dermatologic evaluation of cosmetic formulations containing Chrysanthemum indicum extract.
Kim et al., South Korea. In J Cosmet Dermatol, Feb 2016
AIMS: In this study, we evaluated the ability of C. indicum extracts to inhibit in vitro tyrosinase activity and the skin care effects of cosmetic formulations containing 0.5% C. indicum water extract in human volunteers.
Versatile antitumor potential of isoxanthohumol: enhancement of paclitaxel activity in vivo.
Maksimović-Ivanić et al., Belgrade, Serbia. In Pharmacol Res, Feb 2016
While modified B16 cells underwent the process of non-classic differentiation followed by tyrosinase activity without enhancement of melanin content, inhibition of Notch 1, β-catenin and Oct-3/4 were observed in A375 cells indicating loss of their pluripotent characteristics.
Effect of the mixtures of squid ink tyrosinase and tannic acid on properties of sardine surimi gel.
Benjakul et al., Hat Yai, Thailand. In J Food Sci Technol, Jan 2016
Effect of the mixture of squid ink tyrosinase (SIT) at 300 and 500 U/g protein and tannic acid (TA) at 0.5 and 1 % (based on protein) with different reaction times (90 and 180 min) on gel properties of sardine surimi was investigated.
Biomarkers in triple negative breast cancer: A review.
Jhamb et al., Chandīgarh, India. In World J Clin Oncol, Jan 2016
We included studies with biomarkers including: Epidermal growth factor receptor, vascular endothelial growth factor, c-Myc, C-kit and basal cytokeratins, Poly(ADP-ribose) polymerase-1, p53, tyrosinase kinases, m-TOR, heat and shock proteins and TOP-2A in TNBC.
Identification of six new lupane-type triterpenoids from Acanthopanax koreanum leaves and their tyrosinase inhibitory activities.
Kim et al., Kyŏngsan, South Korea. In Bioorg Med Chem Lett, Jan 2016
These compounds were also evaluated for their tyrosinase inhibitory effects.
Enzymatic processing of protein-based fibers.
Cavaco-Paulo et al., Wuxi, China. In Appl Microbiol Biotechnol, Dec 2015
Fiber biomodification is described here with various classes of enzymes such as protease, transglutaminase, tyrosinase, and laccase.
Phytoremediation of textile dyes and effluents: Current scenario and future prospects.
Govindwar et al., Kolhāpur, India. In Biotechnol Adv, Dec 2015
Plants' oxidoreductases such as lignin peroxidase, laccase, tyrosinase, azo reductase, veratryl alcohol oxidase, riboflavin reductase and dichlorophenolindophenol reductase are known as key biodegrading enzymes which break the complex structures of dyes.
Plant betalains: Chemistry and biochemistry.
Giridhar et al., Mysore, India. In Phytochemistry, Sep 2015
This pathway consists of two key enzymes namely, bifunctional tyrosinase (hydroxylation and oxidation) and DOPA dioxygenase (O2-dependent aromatic ring cleavage).
Low temperature syntheses and reactivity of Cu2O2 active-site models.
Stack et al., Stanford, United States. In Acc Chem Res, Sep 2015
Our recent successes have advanced understanding of the tyrosinase enzyme, and related hemocyanin and NspF, and the copper membrane monooxygenases, specifically particulate methane monooxygenase (pMMO) and ammonia monooxygenase (AMO).
Structural and reactivity models for copper oxygenases: cooperative effects and novel reactivities.
Costas et al., Girona, Spain. In Acc Chem Res, Sep 2015
Tyrosinase is a copper-based O2-activating enzyme, whose structure and reactivity have been widely studied, and that serves as a paradigm for O2 activation at a dimetal site.
Critical review of Ayurvedic Varṇya herbs and their tyrosinase inhibition effect.
Goyal et al., Haridwār, India. In Anc Sci Life, Jul 2015
In Ayurveda, varṇya, raktaprasādana, tvacya are few terms specifying skin lightening with respect to its modern counterpart i.e., Tyrosinase inhibition, the most commonly reported method of skin lightening.
Estimation of Inhibitory Effect against Tyrosinase Activity through Homology Modeling and Molecular Docking.
Nimmanpipug et al., Chiang Mai, Thailand. In Enzyme Res, 2014
Tyrosinase is a key enzyme in melanogenesis.
A polymorphism in IRF4 affects human pigmentation through a tyrosinase-dependent MITF/TFAP2A pathway.
Steingrimsson et al., Iceland. In Cell, 2013
Assays in zebrafish and mice reveal that IRF4 cooperates with MITF to activate expression of Tyrosinase (TYR), an essential enzyme in melanin synthesis.
Directed phenotype switching as an effective antimelanoma strategy.
Rodríguez-López et al., Murcia, Spain. In Cancer Cell, 2013
We show that methotrexate (MTX) induces microphthalmia-associated transcription factor (MITF) expression to inhibit invasiveness and promote differentiation-associated expression of the melanocyte-specific Tyrosinase gene.
MC1R, SLC45A2 and TYR genetic variants involved in melanoma susceptibility in southern European populations: results from a meta-analysis.
Soufir et al., Valencia, Spain. In Eur J Cancer, 2012
Report association between TYR genetic variants and melanoma susceptibilty in southern European patients.
MC1R, ASIP, TYR, and TYRP1 gene variants in a population-based series of multiple primary melanomas.
Andresen et al., Oslo, Norway. In Genes Chromosomes Cancer, 2012
By using a population-based material of high-risk melanoma cases, we demonstrate a significant effect of both MC1R red hair color (RHC) variants and an ASIP haplotype, but could not replicate an association with postulated risk SNPs of TYR and TYRP1.
Next-generation DNA re-sequencing identifies common variants of TYR and HLA-A that modulate the risk of generalized vitiligo via antigen presentation.
Spritz et al., In J Invest Dermatol, 2012
The HLA-A-TYR pathways is involved in antigen presentation and risk in generalized vitiligo.
Melanesian blond hair is caused by an amino acid change in TYRP1.
Myles et al., Stanford, United States. In Science, 2012
Here, we identify an arginine-to-cysteine change at a highly conserved residue in tyrosinase-related protein 1 (TYRP1) as a major determinant of blond hair in Solomon Islanders.
Eye-specific projections of retinogeniculate axons are altered in albino mice.
Mason et al., New York City, United States. In J Neurosci, 2012
Tyrosinase is mutated in the albino dorsal lateral geniculate nucleus, arising from retinal ganglion cell misspecification together with potential perturbations of early activity patterns in the albino retina.
Melanoma cells present high levels of HLA-A2-tyrosinase in association with instability and aberrant intracellular processing of tyrosinase.
Reiter et al., Haifa, Israel. In Eur J Immunol, 2012
Melanoma cells present high levels of HLA-A2-tyrosinase in association with instability and aberrant intracellular processing of tyrosinase.
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