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Gonadotropin-releasing hormone

Type II GnRH receptor, GNRHR2
In non-hominoid primates and non-mammalian vertebrates, the gonadotropin releasing hormone 2 receptor (GnRHR2) encodes a seven-transmembrane G-protein coupled receptor. However, in human, the N-terminus of the predicted protein contains a frameshift and premature stop codon. In human, GnRHR2 transcription occurs but the gene does not likely produce a functional C-terminal multi-transmembrane protein. A non-transcribed pseudogene of GnRHR2 is located on chromosome 14. [provided by RefSeq, Feb 2011] (from NCBI)
Top mentioned proteins: Gonadotropin-Releasing Hormone, GnRH receptor, ACID, Y14, fibrillin-1
Papers on Type II GnRH receptor
The GnRH Antagonist Degarelix Directly Inhibits Benign Prostate Hyperplasia Cell Growth.
Papadopoulos et al., Montréal, Canada. In Horm Metab Res, Nov 2015
Gonadotropin-releasing hormone receptors (GnRHR) have been found in extrapituitary tissues, including the prostate, where they might exert a local effect on tissue growth.
LH-Independent Testosterone Secretion Is Mediated by the Interaction Between GNRH2 and Its Receptor Within Porcine Testes.
White et al., Lincoln, United States. In Biol Reprod, Aug 2015
Unlike classic gonadotropin-releasing hormone 1 (GNRH1), the second mammalian isoform (GNRH2) is an ineffective stimulant of gonadotropin release.
In search of the molecular mechanisms mediating the inhibitory effect of the GnRH antagonist degarelix on human prostate cell growth.
Papadopoulos et al., Montréal, Canada. In Plos One, 2014
The investigated cell lines express GNRHR1 and GNRHR2 and their endogenous ligands.
Gonadotropin-releasing hormone type II antagonist induces apoptosis in MCF-7 and triple-negative MDA-MB-231 human breast cancer cells in vitro and in vivo.
Emons et al., Göttingen, Germany. In Breast Cancer Res, 2009
Data indicate that GnRH-II antagonists seem to be suitable drugs for an efficacious and less-toxic endocrine therapy for breast cancers, including triple-negative breast cancers.
Human myometrium and leiomyomas express gonadotropin-releasing hormone 2 and gonadotropin-releasing hormone 2 receptor.
Catherino et al., Bethesda, United States. In Fertil Steril, 2007
Expression of GnRH2 protein and receptor (GnRHR2) is confirmed in both leiomyoma and patient-matched myometrium.
Identification of a novel pituitary-specific chicken gonadotropin-releasing hormone receptor and its splice variants.
Bédécarrats et al., Guelph, Canada. In Biol Reprod, 2006
Using a combined strategy of PCR and rapid amplification of cDNA ends (RACE), a new GNRHR (chicken GNRHR2) and two splice variants were isolated in domestic fowl (Gallus gallus domesticus).
GnRH-II receptor-like antigenicity in human placenta and in cancers of the human reproductive organs.
Gründker et al., Göttingen, Germany. In Eur J Endocrinol, 2005
Immune histological sections of human placenta and human endometrial, ovarian, and prostate cancers using rabbit anti-human GnRH-II receptor antiserum showed GnRH-II receptor-like staining.
GnRHs and GnRH receptors.
Millar, Edinburgh, United Kingdom. In Anim Reprod Sci, 2005
chimp, sheep and bovine) the Type II GnRH receptor has been silenced.
Inhibition of human type i gonadotropin-releasing hormone receptor (GnRHR) function by expression of a human type II GnRHR gene fragment.
Millar et al., Edinburgh, United Kingdom. In Endocrinology, 2005
the GnRHR-II-reliquum plays a modulatory role in GnRHR-I expression
A transcriptionally active human type II gonadotropin-releasing hormone receptor gene homolog overlaps two genes in the antisense orientation on chromosome 1q.12.
Millar et al., Edinburgh, United Kingdom. In Endocrinology, 2003
Type-II GnRH receptor genes have been characterized recently in nonhuman primates, but the human receptor gene homolog contains a frameshift, a premature stop codon (UGA), and a 3' overlap of the RBM8A gene on chromosome 1q.12.
The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci.
Katz et al., Cape Town, South Africa. In Genomics, 2001
The locus on chromosome 1 encompasses the type II GnRH receptor gene (GNRHR2), which is composed of three exons.
A novel human GnRH receptor homolog gene: abundant and wide tissue distribution of the antisense transcript.
Hapgood et al., Cape Town, South Africa. In J Endocrinol, 1999
Using sequence information for extracellular loop 3 of a putative Type II GnRH receptor from a reptile species, we have looked for a Type II GnRH receptor gene in the human genome EST (expressed sequence tag) database.
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