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Thromboxane A synthase 1

TXAS, TBXAS1, TXA synthase, Ghosal, CYP5A1, CYP5
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] (from NCBI)
Top mentioned proteins: ACID, TXA2, cyclooxygenase, HAD, CAN
Papers on TXAS
Overexpression of OsCYP19-4 increases tolerance to cold stress and enhances grain yield in rice (Oryza sativa).
Cho et al., Namwŏn, South Korea. In J Exp Bot, Jan 2016
AtCYP19-4 (also known as CYP5) was previously identified as interacting in vitro with GNOM, a member of a large family of ARF guanine nucleotide exchange factors that is required for proper polar localization of the auxin efflux carrier PIN1.
Genome-wide selection of superior reference genes for expression studies in Ganoderma lucidum.
Chen et al., Beijing, China. In Gene, Jan 2016
According to the evaluation of RefFinder, cyclophilin 5 (CYP5) was ranked as the most stable reference gene for 27 tested samples under all experimental conditions and eighteen mycelial samples.
Pharmacogenetic study of long-term response to interferon-β treatment in multiple sclerosis.
Martinelli-Boneschi et al., Milano, Italy. In Pharmacogenomics J, Jan 2016
From meta-analysis, 43 markers were associated at P<10(-4), and two of them (rs7298096 and rs4726460) pointed to two genes, NINJ2 and TBXAS1, that were significantly downregulated after IFNβ stimulation in HC (P=3.1 × 10(-9) and 5.6 × 10(-10)).
Downregulation of TBXAS1 in an iron-induced malignant mesothelioma model.
Kiura et al., Okayama, Japan. In Cancer Sci, Oct 2015
In three of the five rats with mesothelioma, array-based comparative genomic hybridization analysis identified a common chromosomal deletion mapped to the chromosomal 4q31 locus, which encompasses the TBXAS1 gene.
Metabolomic analysis revealed the role of DNA methylation in the balance of arachidonic acid metabolism and endothelial activation.
Zhu et al., Tianjin, China. In Biochim Biophys Acta, Oct 2015
Levels of prostaglandin D2 (PGD2) and thromboxane B2 (TXB2), metabolites in the cyclooxygenase (COX) pathway, were significantly increased by 5-AZA treatment in ECs resulting from the induction of PGD2 synthase (PTGDS) and thromboxane A synthase 1 (TBXAS1) expression by DNA hypomethylation.
[Association of single nucleotide polymorphisms of cytochrome P450 gene with susceptibility to gout in ethnic Han males from coastal regions of Shandong province].
Jia et al., Qingdao, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, Aug 2015
Genotyping was carried out with a custom Illumina GoldenGate Genotyping assay to detect SNP rs2275620 of CYP2C8 gene, SNP rs2070676 of CYP2E1 gene, SNP rs837395 of CYP4B1 gene, and SNP rs194150 of TBXAS1 gene.
HuR mediates the synergistic effects of angiotensin II and IL-1β on vascular COX-2 expression and cell migration.
Salaices et al., Madrid, Spain. In Br J Pharmacol, Jun 2015
VSMC migration was reduced by blockade of ERK1/2, HuR, COX-2, TXAS, TP and EP receptors.
Functional role of the conserved i-helix residue I346 in CYP5A1-Nanodiscs.
Das et al., Urbana, United States. In Biophys Chem, May 2015
Thromboxane synthase (CYP5A1) is a non-classical cytochrome P450 (CYP) expressed in human platelets that mediates vascular homeostasis by producing thromboxane A2 (TXA2) through the isomerization of prostaglandin H2 (PGH2).
Ghosal hematodiaphyseal dysplasia-a concise review including an illustrative patient.
Deme et al., Hyderābād, India. In Skeletal Radiol, Mar 2015
Ghosal hematodiaphyseal dysplasia is a rare autosomal recessive disorder characterized by metadiaphyseal dysplasia of long bones and defective hematopoiesis due to fibrosis or sclerosis of bone marrow.
Hippocampal neuronal cyclooxygenase-2 downstream signaling imbalance in a rat model of chronic aluminium gluconate administration.
Yang et al., Chongqing, China. In Behav Brain Funct, 2014
The DP1, EP2, IP, mPGES-1, EP4, PGIS and TXAS mRNA expressions, and the DP1, EP2 and IP protein expressions significantly increased in the Al-treated hippocampus, while the EP3 and FP mRNA and protein expressions and the TP mRNA expression decreased.
Cytochrome P450 (CYP) in fish.
Itakura et al., Kōbe, Japan. In Environ Toxicol Pharmacol, 2012
These genes are classified into 18 CYP families: namely, CYP1, CYP2, CYP3, CYP4, CYP5, CYP7, CYP8, CYP11, CYP17, CYP19, CYP20, CYP21, CYP24, CYP26, CYP27, CYP39, CYP46 and CYP51.We pinpointed eight CYP families: namely, CYP1, CYP2, CYP3, CYP4, CYP11, CYP17, CYP19 and CYP26 in this review because these CYP families are studied in detail.
Reduced methylation of the thromboxane synthase gene is correlated with its increased vascular expression in preeclampsia.
Walsh et al., Richmond, United States. In Hypertension, 2012
Data show that that DNA methylation of the TBXAS1 promoter was decreased and thromboxane synthase expression was increased in omental arteries of preeclamptic women as compared with normal pregnant women.
Upregulation of thromboxane synthase mediates visfatin-induced interleukin-8 expression and angiogenic activity in endothelial cells.
Bae et al., Yangsan, South Korea. In Biochem Biophys Res Commun, 2012
these results showed that visfatin promoted IL-8 production by upregulation of TXAS, leading to angiogenic activation in endothelial cells.
Association analysis of thromboxane A synthase 1 gene polymorphisms with aspirin intolerance in asthmatic patients.
Park et al., Puch'ŏn, South Korea. In Pharmacogenomics, 2011
The rare allele of rs6962291 may play a protective role against aspirin hypersensitivity via a lower catalytic activity of the TBXAS1 gene, attributed to the increase of a nonfunctioning isoform of TBXAS1.
Examination of thromboxane synthase as a prognostic factor and therapeutic target in non-small cell lung cancer.
Pidgeon et al., Dublin, Ireland. In Mol Cancer, 2010
Data suggest that targeting thromboxane synthase alone, or in combination with conventional chemotherapy is a potential therapeutic strategy for NSCLC.
[Association of Rs10487667 genetic polymorphism of thromboxane synthase with myocardial infarction in Uigur population of Xinjiang].
Yu et al., Ürümqi, China. In Zhonghua Yu Fang Yi Xue Za Zhi, 2010
Rs10487667 polymorphism in the CYP5A1 gene might be a risk factor of myocardial infarction in the Uigur population in Xinjiang.
Heritable sclerosing bone disorders: presentation and new molecular mechanisms.
Kornak et al., Paris, France. In Ann N Y Acad Sci, 2010
Finally, a third entity, including Ghosal syndrome and pachydermoperiostosis, is related to mutations in genes of the eicosanoid pathway.
Mechanistic aspects of CYP74 allene oxide synthases and related cytochrome P450 enzymes.
Brash, Nashville, United States. In Phytochemistry, 2009
The existence of CYP5, CYP8A, and the CYP74 enzymes specialized for reaction with fatty acid peroxide substrates presents opportunities for a "different look" at the catalytic cycle of the cytochrome P450s.
Thromboxane synthase mutations in an increased bone density disorder (Ghosal syndrome).
Cormier-Daire et al., Paris, France. In Nat Genet, 2008
Thromboxane synthase mutations in an increased bone density disorder (Ghosal syndrome).
Ghosal type hemato-diaphyseal dysplasia: a rare variety of Engelmann's disease.
Mukherjee et al., Calcutta, India. In Indian J Pediatr, 2007
Ghosal type hemato-diaphyseal dysplasia is a recently described clinical entity.
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