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Potassium channel, subfamily K, member 6

This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: TWIK-1, TREK-1, HAD, TASK-2, ACID
Papers on TWIK-2
Electrogenic transport and K(+) ion channel expression by the human endolymphatic sac epithelium.
Choi et al., Seoul, South Korea. In Sci Rep, 2014
The identified K(+) channels involved in the electrogenic transport were KCNN2, KCNJ14, KCNK2, and KCNK6, and the K(+) transports via those channels are thought to play an important role in the maintenance of the unique ionic milieu of the inner ear fluid.
TWIK-2 channel deficiency leads to pulmonary hypertension through a rho-kinase-mediated process.
Bryan et al., United States. In Hypertension, 2014
TWIK-2 (KCNK6) is a member of the 2-pore domain (K2P) family of potassium channels, which are highly expressed in the vascular system.
Autosomal dominant partial epilepsy with auditory features: a new locus on chromosome 19q13.11-q13.31.
Pippucci et al., Bologna, Italy. In Epilepsia, 2014
Sequence analysis of the most prominent candidate genes within this critical interval (SCN1B, LGI4, KCNK6, and LRFN1) did not reveal any mutation.
Redirecting splicing with bifunctional oligonucleotides.
Chabot et al., Sherbrooke, Canada. In Nucleic Acids Res, 2014
Such modulators can be bifunctional oligonucleotides made of an antisense portion that determines target specificity, and a non-hybridizing tail that recruits proteins or RNA/protein complexes that affect splice site selection (TOSS and TOES, respectively, for targeted oligonucleotide silencer of splicing and targeted oligonucleotide enhancer of splicing).
Solving the Secondary Structure Matching Problem in Cryo-EM De Novo Modeling Using a Constrained K-Shortest Path Graph Algorithm.
He et al., In Ieee/acm Trans Comput Biol Bioinform, 2014
Our method, DP-TOSS, has been tested using α-proteins with maximum 33 helices and α-β proteins up to five helices and 12 β-strands.
Predictors of symptomatic and asymptomatic intracranial atherosclerosis: what is different and why?
TOSS-2 investigators et al., Ulsan, South Korea. In J Atheroscler Thromb, 2013
METHODS: This was a post-hoc analysis of the 'Trials of Cilostazol in Symptomatic intracranial arterial stenosis-2(TOSS-2)' study, which recruited patients with acute symptomatic ICAS receiving intensive medical treatment.
Intensity-based skeletonization of CryoEM gray-scale images using a true segmentation-free algorithm.
He et al., Nashville, United States. In Ieee/acm Trans Comput Biol Bioinform, 2013
The improvements were 62 and 13 percent for Gorgon and DP-TOSS, respectively.
Endothelium-dependent relaxations in the aorta from K(2p)6.1 knockout mice.
Bryan et al., Houston, United States. In Am J Physiol Regul Integr Comp Physiol, 2013
K2P6.1 or TWIK-2, a two-pore domain K channel, is an important regulator of cardiovascular function.
Transcriptional expression of voltage-gated Na⁺ and voltage-independent K⁺ channels in the developing rat superficial dorsal horn.
Baccei et al., Cincinnati, United States. In Neuroscience, 2013
The data also indicate selective, age-dependent changes in the mRNA expression of two-pore domain (K(2P)) K(+) channels, as TWIK-related acid-sensitive K(+) channels TASK-1 (KCNK3) and TASK-3 (KCNK9) were down-regulated during postnatal development in the absence of any changes in the tandem of pore domains in a weak inward rectifying K(+) channel (TWIK) isoforms examined (KCNK1 and KCNK6).
Early interventional treatment with intranasal corticosteroids compared with postonset treatment in pollinosis.
Nishizaki et al., Okayama, Japan. In Ann Allergy Asthma Immunol, 2012
Total ocular symptom score (TOSS), total naso-ocular symptom score (TSS), Allergic Rhinitis and Its Impact (ARIA) on Asthma classification, and safety were the main secondary end points.
Variation in the oxytocin receptor gene is associated with pair-bonding and social behavior.
Westberg et al., Stockholm, Sweden. In Biol Psychiatry, 2012
METHODS: We first genotyped twelve single nucleotide polymorphisms (SNPs) in the TOSS (Twin and Offspring Study in Sweden) (n = 2309) and the TCHAD (Swedish Twin Study of Child and Adolescent Development) (n = 1240), comprising measures of self-reported pair-bonding behavior.
Leak K⁺ channel mRNAs in dorsal root ganglia: relation to inflammation and spontaneous pain behaviour.
Lawson et al., Bristol, United Kingdom. In Mol Cell Neurosci, 2012
This study is the first to demonstrate expression of THIK1, THIK2 and TWIK2 mRNA in DRGs.
A role for two-pore K⁺ channels in modulating Na⁺ absorption and Cl⁻ secretion in normal human bronchial epithelial cells.
Kreindler et al., Shanghai, China. In Am J Physiol Lung Cell Mol Physiol, 2012
Potassium channels, in particular K2P channels, are expressed and functional in the apical membrane of airway epithelial cells
Two-pore domain K⁺ channels regulate membrane potential of isolated human articular chondrocytes.
Giles et al., Calgary, Canada. In J Physiol, 2011
Quantitative PCR showed that transcripts of genes for two-pore domain K(+) channels (KCNK1, KCNK5 and KCNK6), and 'BK' Ca(2+)-activated K(+) channels (KCNMA1) were abundantly expressed.
cGMP does not activate two-pore domain K+ channels in cerebrovascular smooth muscle.
Bryan et al., Houston, United States. In Am J Physiol Heart Circ Physiol, 2009
Although K(2P) channels are highly expressed, K(2P) currents are not activated via the NO/cGMP pathway in rat middle cerebral artery smooth muscle, despite the presence of numerous putative PKG phosphorylation sites
Distribution of two-pore-domain potassium channels in the adult rat vestibular periphery.
Wackym et al., Milwaukee, United States. In Hear Res, 2008
K(2P)6.1 (TWIK 2) immunoreactivity was detected in nerve terminals, blood vessels hair cells and transitional cells of the crista ampullaris and in the somata and neuron fibers of Scarpa's ganglia.
Genomic structure, cochlear expression, and mutation screening of KCNK6, a candidate gene for DFNA4.
Lalwani et al., San Francisco, United States. In J Neurosci Res, 2004
Identification and characterization of Kcnk6 expression within the mammalian cochlea established the gene as a functional candidate for DFNA4.
Molecular and functional properties of two-pore-domain potassium channels.
Lazdunski et al., Antibes, France. In Am J Physiol Renal Physiol, 2000
The weak inward rectifiers TWIK-1 and TWIK-2 are stimulated by activators of protein kinase C and decreased by internal acidification, the baseline TWIK-related acid-sensitive K(+) (TASK)-1 and TASK-2 channels are sensitive to external pH changes in a narrow range near physiological pH, and the TWIK-related (TREK)-1 and TWIK-related arachidonic acid-stimulated K(+) (TRAAK) channels are the first cloned polyunsaturated fatty acids-activated and mechanogated K(+) channels.
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